Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
Identifieur interne : 006131 ( Ncbi/Merge ); précédent : 006130; suivant : 006132Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
Auteurs : Yi-Hua Sun [Taïwan] ; Oswald Ndi Nfor [Taïwan] ; Jing-Yang Huang [Taïwan] ; Yung-Po Liaw [Taïwan]Source :
- Alzheimer's Research & Therapy [ 1758-9193 ] ; 2015.
Abstract
The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older.
Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0.
Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women.
Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts.
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DOI: 10.1186/s13195-015-0150-1
PubMed: 26560125
PubMed Central: 4642684
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Road, Taichung City, 40201 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City</wicri:regionArea><wicri:noRegion>Taichung City</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jing Yang" sort="Huang, Jing Yang" uniqKey="Huang J" first="Jing-Yang" last="Huang">Jing-Yang Huang</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. 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Road, Taichung City, 40201 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City</wicri:regionArea><wicri:noRegion>Taichung City</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jing Yang" sort="Huang, Jing Yang" uniqKey="Huang J" first="Jing-Yang" last="Huang">Jing-Yang Huang</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City</wicri:regionArea><wicri:noRegion>Taichung City</wicri:noRegion></affiliation></author><author><name sortKey="Liaw, Yung Po" sort="Liaw, Yung Po" uniqKey="Liaw Y" first="Yung-Po" last="Liaw">Yung-Po Liaw</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City</wicri:regionArea><wicri:noRegion>Taichung City</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Alzheimer's Research & Therapy</title><idno type="eISSN">1758-9193</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older.</p></sec><sec><title>Methods</title><p>Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0.</p></sec><sec><title>Results</title><p>Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women.</p></sec><sec><title>Conclusions</title><p>Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Association, Ad" uniqKey="Association A">AD Association</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edlich, R" uniqKey="Edlich R">R Edlich</name></author><author><name sortKey="Cross, Cl" uniqKey="Cross C">CL Cross</name></author><author><name sortKey="Wack, Ca" uniqKey="Wack C">CA Wack</name></author><author><name sortKey="Long, Wb" uniqKey="Long W">WB Long</name></author><author><name sortKey="Newkirk, At" uniqKey="Newkirk A">AT 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Alzheimers Res Ther</journal-id><journal-id journal-id-type="iso-abbrev">Alzheimers Res Ther</journal-id><journal-title-group><journal-title>Alzheimer's Research & Therapy</journal-title></journal-title-group><issn pub-type="epub">1758-9193</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26560125</article-id><article-id pub-id-type="pmc">4642684</article-id><article-id pub-id-type="publisher-id">150</article-id><article-id pub-id-type="doi">10.1186/s13195-015-0150-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Yi-Hua</given-names></name><address><email>irisyihuasun@gmail.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Nfor</surname><given-names>Oswald Ndi</given-names></name><address><email>nforoswald2@yahoo.com</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jing-Yang</given-names></name><address><email>wchinyang@yahoo.com.tw</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Liaw</surname><given-names>Yung-Po</given-names></name><address><phone>+886-4-24730022</phone><email>Liawyp@csmu.edu.tw</email></address><xref ref-type="aff" rid="Aff2"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><aff id="Aff1"><label></label>School of Dentistry, Chung Shan Medical University, Taichung City, 40201 Taiwan</aff><aff id="Aff2"><label></label>Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201 Taiwan</aff><aff id="Aff3"><label></label>Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>7</volume><elocation-id>65</elocation-id><history><date date-type="received"><day>9</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>28</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© Sun et al. 2015</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Introduction</title><p>The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older.</p></sec><sec><title>Methods</title><p>Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0.</p></sec><sec><title>Results</title><p>Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women.</p></sec><sec><title>Conclusions</title><p>Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Sun, Yi Hua" sort="Sun, Yi Hua" uniqKey="Sun Y" first="Yi-Hua" last="Sun">Yi-Hua Sun</name></noRegion><name sortKey="Huang, Jing Yang" sort="Huang, Jing Yang" uniqKey="Huang J" first="Jing-Yang" last="Huang">Jing-Yang Huang</name><name sortKey="Liaw, Yung Po" sort="Liaw, Yung Po" uniqKey="Liaw Y" first="Yung-Po" last="Liaw">Yung-Po Liaw</name><name sortKey="Liaw, Yung Po" sort="Liaw, Yung Po" uniqKey="Liaw Y" first="Yung-Po" last="Liaw">Yung-Po Liaw</name><name sortKey="Nfor, Oswald Ndi" sort="Nfor, Oswald Ndi" uniqKey="Nfor O" first="Oswald Ndi" last="Nfor">Oswald Ndi Nfor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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