Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)
Identifieur interne : 005F78 ( Ncbi/Merge ); précédent : 005F77; suivant : 005F79Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)
Auteurs : Oelisoa M. Andriankaja ; James J. Jiménez ; Francisco J. Mu Oz-Torres ; Cynthia M. Pérez ; José L. Vergara ; Kaumudi JoshipuraSource :
- Journal of clinical periodontology [ 0303-6979 ] ; 2015.
Abstract
The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.
To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.
Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.
24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).
Lipid-lowering agents may reduce both systemic and oral inflammatory responses.
Url:
DOI: 10.1111/jcpe.12461
PubMed: 26407668
PubMed Central: 4808494
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002621
- to stream Pmc, to step Curation: 002621
- to stream Pmc, to step Checkpoint: 000D01
Links to Exploration step
PMC:4808494Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</title><author><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26407668</idno><idno type="pmc">4808494</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808494</idno><idno type="RBID">PMC:4808494</idno><idno type="doi">10.1111/jcpe.12461</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002621</idno><idno type="wicri:Area/Pmc/Curation">002621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002621</idno><idno type="wicri:Area/Pmc/Checkpoint">000D01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D01</idno><idno type="wicri:Area/Ncbi/Merge">005F78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</title><author><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author><author><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name><affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff><wicri:noCountry code="subfield">University of Puerto Rico</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.</p><sec id="S1"><title>Objective</title><p id="P2">To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.</p></sec><sec id="S2"><title>Design</title><p id="P3">Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.</p></sec><sec id="S3"><title>Results</title><p id="P4">24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Lipid-lowering agents may reduce both systemic and oral inflammatory responses.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id><journal-id journal-id-type="pubmed-jr-id">4645</journal-id><journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id><journal-title-group><journal-title>Journal of clinical periodontology</journal-title></journal-title-group><issn pub-type="ppub">0303-6979</issn><issn pub-type="epub">1600-051X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26407668</article-id><article-id pub-id-type="pmc">4808494</article-id><article-id pub-id-type="doi">10.1111/jcpe.12461</article-id><article-id pub-id-type="manuscript">NIHMS725781</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Andriankaja</surname><given-names>Oelisoa M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jiménez</surname><given-names>James J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Muñoz-Torres</surname><given-names>Francisco J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pérez</surname><given-names>Cynthia M.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Vergara</surname><given-names>José L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Joshipura</surname><given-names>Kaumudi</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</aff><aff id="A2"><label>2</label>Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</aff><author-notes><corresp id="cor1"><bold><italic>Corresponding author:</italic></bold> Oelisoa M. Andriankaja, DDS, MS, PhD, Center for Clinical Research and Health Promotion, University of Puerto Rico, School of Dental Medicine, Office A107, Box 365067, San Juan, PR 00936-5067, Tel: 787 758-2525 ext. 1182, Fax: 787-763-4868, <email>Oelisoa.andriankaja@upr.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>12</month><year>2016</year></pub-date><volume>42</volume><issue>12</issue><fpage>1090</fpage><lpage>1096</lpage><pmc-comment>elocation-id from pubmed: 10.1111/jcpe.12461</pmc-comment>
<abstract><p id="P1">The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.</p><sec id="S1"><title>Objective</title><p id="P2">To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.</p></sec><sec id="S2"><title>Design</title><p id="P3">Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.</p></sec><sec id="S3"><title>Results</title><p id="P4">24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">Lipid-lowering agents may reduce both systemic and oral inflammatory responses.</p></sec></abstract><kwd-group><title>Key terms</title><kwd>Lipid lowering agents</kwd><kwd>statins</kwd><kwd>periodontitis</kwd><kwd>systemic inflammation</kwd><kwd>hs-CRP</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 005F78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:4808494
|texte= Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:26407668" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |