Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation
Identifieur interne : 005F00 ( Ncbi/Merge ); précédent : 005E99; suivant : 005F01Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation
Auteurs : Masumeh Faramarzi [Iran] ; Zahra Goharfar ; Reza Pourabbas [Iran] ; Atabak Kashefimehr [Iran] ; Adileh Shirmohmmadi [Iran]Source :
- Journal of the Korean Association of Oral and Maxillofacial Surgeons [ 2234-7550 ] ; 2015.
Abstract
The purpose of this study was to compare the microbial and clinical effects of mechanical debridement (MD) alone or in combination with the application of enamel matrix derivative (EMD) and sustained-release micro-spherical minocycline (MSM) for treatment of peri-implant mucosal infl ammation (PIMI).
Subjects with at least one implant with PIMI were included and divided into control and two different test groups. In all three groups, MD was performed. In the MSM group, following MD, MSM was placed subgingivally around the implants. In the EMD group, after MD, EMD was placed in the sulcus around the implants. Sampling of peri-implant crevicular fl uid for microbial analysis with real-time polymerase chain reaction and recording of probing depth (PD) and bleeding on probing (BOP) were performed prior to as well as two weeks and three months after treatment. Median values and interquartile range were estimated for each variable during the various assessment intervals of the study.
In all groups, at two weeks and three months, the counts of
The use of MSM and EMD can be an adjunctive treatment for management of PIMI and improves clinical parameters and reduces
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DOI: 10.5125/jkaoms.2015.41.4.181
PubMed: 26339576
PubMed Central: 4558186
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation</title><author><name sortKey="Faramarzi, Masumeh" sort="Faramarzi, Masumeh" uniqKey="Faramarzi M" first="Masumeh" last="Faramarzi">Masumeh Faramarzi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Goharfar, Zahra" sort="Goharfar, Zahra" uniqKey="Goharfar Z" first="Zahra" last="Goharfar">Zahra Goharfar</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Pourabbas, Reza" sort="Pourabbas, Reza" uniqKey="Pourabbas R" first="Reza" last="Pourabbas">Reza Pourabbas</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Kashefimehr, Atabak" sort="Kashefimehr, Atabak" uniqKey="Kashefimehr A" first="Atabak" last="Kashefimehr">Atabak Kashefimehr</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Shirmohmmadi, Adileh" sort="Shirmohmmadi, Adileh" uniqKey="Shirmohmmadi A" first="Adileh" last="Shirmohmmadi">Adileh Shirmohmmadi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26339576</idno><idno type="pmc">4558186</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558186</idno><idno type="RBID">PMC:4558186</idno><idno type="doi">10.5125/jkaoms.2015.41.4.181</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000351</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000351</idno><idno type="wicri:Area/Pmc/Curation">000351</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000351</idno><idno type="wicri:Area/Pmc/Checkpoint">000C61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C61</idno><idno type="wicri:Area/Ncbi/Merge">005F00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation</title><author><name sortKey="Faramarzi, Masumeh" sort="Faramarzi, Masumeh" uniqKey="Faramarzi M" first="Masumeh" last="Faramarzi">Masumeh Faramarzi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Goharfar, Zahra" sort="Goharfar, Zahra" uniqKey="Goharfar Z" first="Zahra" last="Goharfar">Zahra Goharfar</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Pourabbas, Reza" sort="Pourabbas, Reza" uniqKey="Pourabbas R" first="Reza" last="Pourabbas">Reza Pourabbas</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Kashefimehr, Atabak" sort="Kashefimehr, Atabak" uniqKey="Kashefimehr A" first="Atabak" last="Kashefimehr">Atabak Kashefimehr</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Shirmohmmadi, Adileh" sort="Shirmohmmadi, Adileh" uniqKey="Shirmohmmadi A" first="Adileh" last="Shirmohmmadi">Adileh Shirmohmmadi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Iran</country><wicri:regionArea>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of the Korean Association of Oral and Maxillofacial Surgeons</title><idno type="ISSN">2234-7550</idno><idno type="eISSN">2234-5930</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>The purpose of this study was to compare the microbial and clinical effects of mechanical debridement (MD) alone or in combination with the application of enamel matrix derivative (EMD) and sustained-release micro-spherical minocycline (MSM) for treatment of peri-implant mucosal infl ammation (PIMI).</p></sec><sec><title>Materials and Methods</title><p>Subjects with at least one implant with PIMI were included and divided into control and two different test groups. In all three groups, MD was performed. In the MSM group, following MD, MSM was placed subgingivally around the implants. In the EMD group, after MD, EMD was placed in the sulcus around the implants. Sampling of peri-implant crevicular fl uid for microbial analysis with real-time polymerase chain reaction and recording of probing depth (PD) and bleeding on probing (BOP) were performed prior to as well as two weeks and three months after treatment. Median values and interquartile range were estimated for each variable during the various assessment intervals of the study.</p></sec><sec><title>Results</title><p>In all groups, at two weeks and three months, the counts of <italic>Porphyromonas gingivalis</italic> decreased significantly compared to baseline. Levels of <italic>P. gingivalis</italic> were significantly reduced in MSM (<italic>P</italic><0.001) and EMD (<italic>P</italic>=0.026) groups compared to the control group. Also, clinical parameters improved significantly at two weeks and three months. Reduction of PD was significant in MSM (<italic>P</italic><0.001) and EMD (<italic>P</italic><0.001) groups. The decrease in BOP in the MSM, EMD, and control groups was 60%, 50%, and 20%, respectively.</p></sec><sec><title>Conclusion</title><p>The use of MSM and EMD can be an adjunctive treatment for management of PIMI and improves clinical parameters and reduces <italic>P. gingivalis</italic> burden three months after treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Misch, Ce" uniqKey="Misch C">CE Misch</name></author><author><name sortKey="Perel, Ml" uniqKey="Perel M">ML Perel</name></author><author><name sortKey="Wang, Hl" uniqKey="Wang H">HL Wang</name></author><author><name sortKey="Sammartino, G" uniqKey="Sammartino G">G Sammartino</name></author><author><name sortKey="Galindo Moreno, P" uniqKey="Galindo Moreno P">P Galindo-Moreno</name></author><author><name sortKey="Trisi, P" uniqKey="Trisi P">P Trisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, M" uniqKey="Esposito 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Assoc Oral Maxillofac Surg</journal-id><journal-id journal-id-type="iso-abbrev">J Korean Assoc Oral Maxillofac Surg</journal-id><journal-id journal-id-type="publisher-id">JKAOMS</journal-id><journal-title-group><journal-title>Journal of the Korean Association of Oral and Maxillofacial Surgeons</journal-title></journal-title-group><issn pub-type="ppub">2234-7550</issn><issn pub-type="epub">2234-5930</issn><publisher><publisher-name>The Korean Association of Oral and Maxillofacial Surgeons</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26339576</article-id><article-id pub-id-type="pmc">4558186</article-id><article-id pub-id-type="doi">10.5125/jkaoms.2015.41.4.181</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Faramarzi</surname><given-names>Masumeh</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Goharfar</surname><given-names>Zahra</given-names></name><xref ref-type="aff" rid="A2">1</xref></contrib><contrib contrib-type="author"><name><surname>Pourabbas</surname><given-names>Reza</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kashefimehr</surname><given-names>Atabak</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shirmohmmadi</surname><given-names>Adileh</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.</aff><aff id="A2"><label>2</label>Department of Periodontics, Urmia University of Medical Sciences, Urmia, Iran.</aff><author-notes><corresp>Corresponding author: Masumeh Faramarzi. Department of Periodontics, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Golgasht Street, Tabriz 5165665931, Iran. TEL: +98-9143417521, FAX: +98-4133346977, <email>faramarzie@hotmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>21</day><month>8</month><year>2015</year></pub-date><volume>41</volume><issue>4</issue><fpage>181</fpage><lpage>189</lpage><history><date date-type="received"><day>01</day><month>3</month><year>2015</year></date><date date-type="rev-recd"><day>18</day><month>4</month><year>2015</year></date><date date-type="accepted"><day>03</day><month>5</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Objectives</title><p>The purpose of this study was to compare the microbial and clinical effects of mechanical debridement (MD) alone or in combination with the application of enamel matrix derivative (EMD) and sustained-release micro-spherical minocycline (MSM) for treatment of peri-implant mucosal infl ammation (PIMI).</p></sec><sec><title>Materials and Methods</title><p>Subjects with at least one implant with PIMI were included and divided into control and two different test groups. In all three groups, MD was performed. In the MSM group, following MD, MSM was placed subgingivally around the implants. In the EMD group, after MD, EMD was placed in the sulcus around the implants. Sampling of peri-implant crevicular fl uid for microbial analysis with real-time polymerase chain reaction and recording of probing depth (PD) and bleeding on probing (BOP) were performed prior to as well as two weeks and three months after treatment. Median values and interquartile range were estimated for each variable during the various assessment intervals of the study.</p></sec><sec><title>Results</title><p>In all groups, at two weeks and three months, the counts of <italic>Porphyromonas gingivalis</italic> decreased significantly compared to baseline. Levels of <italic>P. gingivalis</italic> were significantly reduced in MSM (<italic>P</italic><0.001) and EMD (<italic>P</italic>=0.026) groups compared to the control group. Also, clinical parameters improved significantly at two weeks and three months. Reduction of PD was significant in MSM (<italic>P</italic><0.001) and EMD (<italic>P</italic><0.001) groups. The decrease in BOP in the MSM, EMD, and control groups was 60%, 50%, and 20%, respectively.</p></sec><sec><title>Conclusion</title><p>The use of MSM and EMD can be an adjunctive treatment for management of PIMI and improves clinical parameters and reduces <italic>P. gingivalis</italic> burden three months after treatment.</p></sec></abstract><kwd-group><kwd>Debridement</kwd><kwd>Infl ammation</kwd><kwd>Minocycline</kwd><kwd>Real-time polymerase chain reaction</kwd><kwd>Peri-implantitis</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Study flowchart.</title><p>Masumeh Faramarzi et al: Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg 2015</p></caption><graphic xlink:href="jkaoms-41-181-g001"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Demographic information of the study subjects at baseline</title></caption><alternatives><graphic xlink:href="jkaoms-41-181-i001"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="middle" align="center" rowspan="1" colspan="1">Demographic characteristic</th><th valign="middle" align="center" rowspan="1" colspan="1">MSM</th><th valign="middle" align="center" rowspan="1" colspan="1">EMD</th><th valign="middle" align="center" rowspan="1" colspan="1">Control</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Number of patients</td><td valign="top" align="center" rowspan="1" colspan="1">23</td><td valign="top" align="center" rowspan="1" colspan="1">20</td><td valign="top" align="center" rowspan="1" colspan="1">21</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Gender (female/male)</td><td valign="top" align="center" rowspan="1" colspan="1">11/12</td><td valign="top" align="center" rowspan="1" colspan="1">10/10</td><td valign="top" align="center" rowspan="1" colspan="1">10/11</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Age (yr)</td><td valign="top" align="center" rowspan="1" colspan="1">48.4±2.9</td><td valign="top" align="center" rowspan="1" colspan="1">49.9±2.9</td><td valign="top" align="center" rowspan="1" colspan="1">45.6±2.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Location</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Anterior max/posterior max</td><td valign="top" align="center" rowspan="1" colspan="1">2/9</td><td valign="top" align="center" rowspan="1" colspan="1">3/8</td><td valign="top" align="center" rowspan="1" colspan="1">3/8</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Anterior man/posterior man</td><td valign="top" align="center" rowspan="1" colspan="1">4/8</td><td valign="top" align="center" rowspan="1" colspan="1">3/6</td><td valign="top" align="center" rowspan="1" colspan="1">8/2</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total number of implants</td><td valign="top" align="center" rowspan="1" colspan="1">3.4±0.6</td><td valign="top" align="center" rowspan="1" colspan="1">3.0±0.5</td><td valign="top" align="center" rowspan="1" colspan="1">3.7±0.6</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">History of periodontitis</td><td valign="top" align="center" rowspan="1" colspan="1">11 (47.8)</td><td valign="top" align="center" rowspan="1" colspan="1">10 (50.0)</td><td valign="top" align="center" rowspan="1" colspan="1">10 (47.6)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Prosthesis (overdenture/bridge/crown)</td><td valign="top" align="center" rowspan="1" colspan="1">15/4/4</td><td valign="top" align="center" rowspan="1" colspan="1">13/5/2</td><td valign="top" align="center" rowspan="1" colspan="1">6/10/5</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">History of GBR treatment</td><td valign="top" align="center" rowspan="1" colspan="1">6</td><td valign="top" align="center" rowspan="1" colspan="1">7</td><td valign="top" align="center" rowspan="1" colspan="1">4</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Surgical protocol (one/two stage)</td><td valign="top" align="center" rowspan="1" colspan="1">8/15</td><td valign="top" align="center" rowspan="1" colspan="1">3/17</td><td valign="top" align="center" rowspan="1" colspan="1">4/17</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>(MSM: micro-spherical minocycline, EMD: enamel matrix derivative, max: maxilla, man: mandible, GBR: guided bone regeneration)</p><p>Values are presented as number, mean±standard deviation, or number (%).</p><p>Masumeh Faramarzi et al: Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg 2015</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Intra- and inter-group comparison of clinical and microbial parameters among MD and MD+microspherical minocyclin groups at baseline and two weeks and three months after treatment</title></caption><alternatives><graphic xlink:href="jkaoms-41-181-i002"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="middle" align="center" rowspan="2" colspan="1">Parameter</th><th valign="middle" align="center" rowspan="1" colspan="3">MD</th><th valign="middle" align="center" rowspan="1" colspan="3">MD+microspherical minocyclin</th><th valign="middle" align="center" rowspan="1" colspan="3">Inter-group comparison, <italic>P</italic>-value<sup>2</sup></th></tr><tr><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="2" colspan="1">PD (mm)</td><td valign="top" align="center" rowspan="2" colspan="1">4.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="1" colspan="1">5.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="2" colspan="1">4.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="2" colspan="1">4.00 (5.00-5.00)</td><td valign="top" align="center" rowspan="1" colspan="1">2.00 (2.00-2.00)</td><td valign="top" align="center" rowspan="2" colspan="1">2.00 (2.00-3.00)</td><td valign="top" align="center" rowspan="2" colspan="1">0.200</td><td valign="top" align="right" rowspan="2" colspan="1">0.000</td><td valign="top" align="right" rowspan="2" colspan="1">0.000</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic>=0.098<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr><tr><td valign="top" align="left" rowspan="2" colspan="1">BOP (%)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (75.00-100.00)</td><td valign="top" align="center" rowspan="1" colspan="1">75.00 (50.00-100.00)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (50.00-100.00)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (75.00-100.00)</td><td valign="top" align="center" rowspan="1" colspan="1">0.00 (0.00-25.00)</td><td valign="top" align="center" rowspan="2" colspan="1">0.00 (0.00-25.00)</td><td valign="top" align="center" rowspan="2" colspan="1">0.179</td><td valign="top" align="right" rowspan="2" colspan="1">0.000</td><td valign="top" align="right" rowspan="2" colspan="1">0.000</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic>=0.109<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr><tr><td valign="top" align="left" rowspan="2" colspan="1"><italic>P. gingivalis</italic> (IU/mL)</td><td valign="top" align="center" rowspan="2" colspan="1">132.00 (29.00-221.50)</td><td valign="top" align="center" rowspan="1" colspan="1">114.00 (23.50-143.00)</td><td valign="top" align="center" rowspan="2" colspan="1">125.00 (26.00-160.50)</td><td valign="top" align="center" rowspan="2" colspan="1">115.00 (55.00-155.00)</td><td valign="top" align="center" rowspan="1" colspan="1">12.00 (0.00-36.00)</td><td valign="top" align="center" rowspan="2" colspan="1">21.00 (8.00-34.00)</td><td valign="top" align="center" rowspan="2" colspan="1">0.934</td><td valign="top" align="right" rowspan="2" colspan="1"><0.001</td><td valign="top" align="right" rowspan="2" colspan="1"><0.001</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>(MD: mechanical debridement, PD: probing depth, BOP: bleeding on probing, <italic>P. gingivalis</italic>: <italic>Porphyromonas gingivalis</italic>)</p><p><sup>1</sup>Friedman test. <sup>2</sup>Mann-Whitney U test.</p><p>Values are presented as median (interquartile range).</p><p>Masumeh Faramarzi et al: Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg 2015</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><title>Intra- and inter-group comparison of clinical and microbial parameters among MD and MD+EMD groups at baseline and two weeks and three months after treatment</title></caption><alternatives><graphic xlink:href="jkaoms-41-181-i003"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="middle" align="center" rowspan="2" colspan="1">Parameter</th><th valign="middle" align="center" rowspan="1" colspan="3">MD</th><th valign="middle" align="center" rowspan="1" colspan="3">MD+EMD</th><th valign="middle" align="center" rowspan="1" colspan="3">Inter-group comparison, <italic>P</italic>-value<sup>2</sup></th></tr><tr><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">Baseline</th><th valign="middle" align="center" rowspan="1" colspan="1">2 wk follow-up</th><th valign="middle" align="center" rowspan="1" colspan="1">3 mo follow-up</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="2" colspan="1">PD (mm)</td><td valign="top" align="center" rowspan="2" colspan="1">4.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="1" colspan="1">5.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="2" colspan="1">4.00 (5.00-6.00)</td><td valign="top" align="center" rowspan="2" colspan="1">4.50 (4.00-5.00)</td><td valign="top" align="center" rowspan="1" colspan="1">4.00 (3.50-5.00)</td><td valign="top" align="center" rowspan="2" colspan="1">3.00 (2.00-4.37)</td><td valign="top" align="right" rowspan="2" colspan="1">0.209</td><td valign="top" align="right" rowspan="2" colspan="1"><0.001</td><td valign="top" align="right" rowspan="2" colspan="1"><0.001</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic>=0.098<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr><tr><td valign="top" align="left" rowspan="2" colspan="1">BOP (%)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (75.00-100.00)</td><td valign="top" align="center" rowspan="1" colspan="1">75.00 (50.00-100.00)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (50.00-100.00)</td><td valign="top" align="center" rowspan="2" colspan="1">75.00 (75.00-100.00)</td><td valign="top" align="center" rowspan="1" colspan="1">75.00 (50.00-93.70)</td><td valign="top" align="center" rowspan="2" colspan="1">25.00 (0.00-50.00)</td><td valign="top" align="right" rowspan="2" colspan="1">0.602</td><td valign="top" align="right" rowspan="2" colspan="1">0.234</td><td valign="top" align="right" rowspan="2" colspan="1"><0.001</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic>=0.109<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr><tr><td valign="top" align="left" rowspan="2" colspan="1"><italic>P. gingivalis</italic> (IU/mL)</td><td valign="top" align="center" rowspan="2" colspan="1">132.00 (29.00-221.50)</td><td valign="top" align="center" rowspan="1" colspan="1">114.00 (23.50-143.00)</td><td valign="top" align="center" rowspan="2" colspan="1">125.00 (26.00-160.50)</td><td valign="top" align="center" rowspan="2" colspan="1">17.50 (0.00-91.75)</td><td valign="top" align="center" rowspan="1" colspan="1">0.00 (0.00-119.00)</td><td valign="top" align="center" rowspan="2" colspan="1">0.00 (0.00-271.50)</td><td valign="top" align="right" rowspan="2" colspan="1">0.082</td><td valign="top" align="right" rowspan="2" colspan="1">0.007</td><td valign="top" align="right" rowspan="2" colspan="1">0.026</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td><td valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic><0.001<sup>1</sup></td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>(MD: mechanical debridement, EMD: enamel matrix derivative, PD: probing depth, BOP: bleeding on probing, <italic>P. gingivalis</italic>: <italic>Porphyromonas gingivalis</italic>)</p><p><sup>1</sup>Friedman test. <sup>2</sup>Mann-Whitney U test.</p><p>Values are presented as median (interquartile range).</p><p>Masumeh Faramarzi et al: Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg 2015</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Iran</li></country></list><tree><noCountry><name sortKey="Goharfar, Zahra" sort="Goharfar, Zahra" uniqKey="Goharfar Z" first="Zahra" last="Goharfar">Zahra Goharfar</name></noCountry><country name="Iran"><noRegion><name sortKey="Faramarzi, Masumeh" sort="Faramarzi, Masumeh" uniqKey="Faramarzi M" first="Masumeh" last="Faramarzi">Masumeh Faramarzi</name></noRegion><name sortKey="Kashefimehr, Atabak" sort="Kashefimehr, Atabak" uniqKey="Kashefimehr A" first="Atabak" last="Kashefimehr">Atabak Kashefimehr</name><name sortKey="Pourabbas, Reza" sort="Pourabbas, Reza" uniqKey="Pourabbas R" first="Reza" last="Pourabbas">Reza Pourabbas</name><name sortKey="Shirmohmmadi, Adileh" sort="Shirmohmmadi, Adileh" uniqKey="Shirmohmmadi A" first="Adileh" last="Shirmohmmadi">Adileh Shirmohmmadi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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