Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?
Identifieur interne : 005E17 ( Ncbi/Merge ); précédent : 005E16; suivant : 005E18Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?
Auteurs : Adi Idris ; Nur B. Ghazali ; David KohSource :
- Biomarkers in Cancer [ 1179-299X ] ; 2015.
Abstract
The relationship between cancer and inflammation is a complex but intimate one. Decades of work has shown to us that cancer progression is influenced by a multitude of factors, including genetic, environmental, and immunological factors. We often overlook that cancer progression is also a pathological consequence of a dysregulated inflammatory control in the body. A current emerging topic in cancer research is the role of inflammasomes in carcinogenesis. The inflammasome is a multicomplex protein platform that when activated results in the release of proinflammatory cytokines, such as interleukin (IL)-1β. There is increasing evidence suggesting that IL-1β plays a pivotal role in cancer progression. This short review proposes the possibility of using IL-1β as a potential cancer progression biomarker and discusses the use of saliva as a model biological fluid for measuring physiological IL-1β levels in the body.
Url:
DOI: 10.4137/BIC.S25375
PubMed: 26244033
PubMed Central: 4498652
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?</title><author><name sortKey="Idris, Adi" sort="Idris, Adi" uniqKey="Idris A" first="Adi" last="Idris">Adi Idris</name></author><author><name sortKey="Ghazali, Nur B" sort="Ghazali, Nur B" uniqKey="Ghazali N" first="Nur B" last="Ghazali">Nur B. Ghazali</name></author><author><name sortKey="Koh, David" sort="Koh, David" uniqKey="Koh D" first="David" last="Koh">David Koh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26244033</idno><idno type="pmc">4498652</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498652</idno><idno type="RBID">PMC:4498652</idno><idno type="doi">10.4137/BIC.S25375</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000461</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000461</idno><idno type="wicri:Area/Pmc/Curation">000461</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000461</idno><idno type="wicri:Area/Pmc/Checkpoint">000D18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D18</idno><idno type="wicri:Area/Ncbi/Merge">005E17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?</title><author><name sortKey="Idris, Adi" sort="Idris, Adi" uniqKey="Idris A" first="Adi" last="Idris">Adi Idris</name></author><author><name sortKey="Ghazali, Nur B" sort="Ghazali, Nur B" uniqKey="Ghazali N" first="Nur B" last="Ghazali">Nur B. Ghazali</name></author><author><name sortKey="Koh, David" sort="Koh, David" uniqKey="Koh D" first="David" last="Koh">David Koh</name></author></analytic><series><title level="j">Biomarkers in Cancer</title><idno type="eISSN">1179-299X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The relationship between cancer and inflammation is a complex but intimate one. Decades of work has shown to us that cancer progression is influenced by a multitude of factors, including genetic, environmental, and immunological factors. We often overlook that cancer progression is also a pathological consequence of a dysregulated inflammatory control in the body. A current emerging topic in cancer research is the role of inflammasomes in carcinogenesis. The inflammasome is a multicomplex protein platform that when activated results in the release of proinflammatory cytokines, such as interleukin (IL)-1β. There is increasing evidence suggesting that IL-1β plays a pivotal role in cancer progression. This short review proposes the possibility of using IL-1β as a potential cancer progression biomarker and discusses the use of saliva as a model biological fluid for measuring physiological IL-1β levels in the body.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Spielmann, N" uniqKey="Spielmann N">N Spielmann</name></author><author><name sortKey="Wong, Dt" uniqKey="Wong D">DT Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiwari, M" uniqKey="Tiwari M">M Tiwari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmermann, Bg" uniqKey="Zimmermann B">BG Zimmermann</name></author><author><name sortKey="Park, Nj" uniqKey="Park N">NJ Park</name></author><author><name sortKey="Wong, Dt" uniqKey="Wong D">DT Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinarello, Ca" uniqKey="Dinarello C">CA 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomark Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Biomark Cancer</journal-id><journal-id journal-id-type="publisher-id">Biomarkers in Cancer</journal-id><journal-title-group><journal-title>Biomarkers in Cancer</journal-title></journal-title-group><issn pub-type="epub">1179-299X</issn><publisher><publisher-name>Libertas Academica</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26244033</article-id><article-id pub-id-type="pmc">4498652</article-id><article-id pub-id-type="doi">10.4137/BIC.S25375</article-id><article-id pub-id-type="publisher-id">bic-7-2015-025</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Review</subject></subj-group></article-categories><title-group><article-title>Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Idris</surname><given-names>Adi</given-names></name><xref ref-type="corresp" rid="c1-bic-7-2015-025"></xref></contrib><contrib contrib-type="author"><name><surname>Ghazali</surname><given-names>Nur B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Koh</surname><given-names>David</given-names></name></contrib><aff id="af1-bic-7-2015-025">Jalan Tungku Link Gadong, PAP Rashidah Sa’adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam.</aff></contrib-group><author-notes><corresp id="c1-bic-7-2015-025">CORRESPONDENCE: <email>yusri.idris@ubd.edu.bn</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>08</day><month>7</month><year>2015</year></pub-date><volume>7</volume><fpage>25</fpage><lpage>29</lpage><history><date date-type="received"><day>03</day><month>3</month><year>2015</year></date><date date-type="rev-recd"><day>23</day><month>4</month><year>2015</year></date><date date-type="accepted"><day>25</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 the author(s), publisher and licensee Libertas Academica Ltd.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access"><license-p>This is an open access article published under the Creative Commons CC-BY-NC 3.0 License.</license-p></license></permissions><abstract><p>The relationship between cancer and inflammation is a complex but intimate one. Decades of work has shown to us that cancer progression is influenced by a multitude of factors, including genetic, environmental, and immunological factors. We often overlook that cancer progression is also a pathological consequence of a dysregulated inflammatory control in the body. A current emerging topic in cancer research is the role of inflammasomes in carcinogenesis. The inflammasome is a multicomplex protein platform that when activated results in the release of proinflammatory cytokines, such as interleukin (IL)-1β. There is increasing evidence suggesting that IL-1β plays a pivotal role in cancer progression. This short review proposes the possibility of using IL-1β as a potential cancer progression biomarker and discusses the use of saliva as a model biological fluid for measuring physiological IL-1β levels in the body.</p></abstract><kwd-group><kwd>interleukin 1</kwd><kwd>saliva</kwd><kwd>cancer</kwd><kwd>biomarker</kwd><kwd>inflammasome</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-bic-7-2015-025" position="float"><label>Figure 1</label><caption><p>The inflammasome is a multicomplex system whose activation can be induced by exposure to carcinogens or intrinsic genetic aberrations, the basis of cancer initiation. Upon inflammasome activation, caspase 1 becomes activated, which leads to a cascade of proinflammatory events via the activation of cytokines, such as IL-1β, which then interact with their own membrane receptors amplifying the inflammatory response. On the other hand, active caspase 1 can lead to cell pyroptosis with the consequence of membrane rupture and release of various factors, including IL-1β. Inflammasome effectors (IL-1-like cytokines and pyroptosis) can influence the adaptive immune response and cell proliferative responses in different ways. The activation of the inflammasome complex can lead to the recruitment of suppressive immune cells, such Type 2 helper T-cells (Th2) and regulatory T-cells (Treg), which can favor tumor progression. The inflammasome is also involved in tumor progression through the release of growth factors [eg, fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF)], which facilitate angiogenesis and tumor invasiveness.</p></caption><graphic xlink:href="bic-7-2015-025f1"></graphic></fig><table-wrap id="t1-bic-7-2015-025" position="float"><label>Table 1</label><caption><p>Cancers with identifiable changes in saliva.</p></caption><table frame="box" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">TYPE OF CANCER</th><th valign="top" align="left" rowspan="1" colspan="1">TYPE</th><th valign="top" align="left" rowspan="1" colspan="1">SOURCE</th><th valign="top" align="left" rowspan="1" colspan="1">BIOMARKER</th><th valign="top" align="left" rowspan="1" colspan="1">REF</th></tr></thead><tbody><tr><td valign="middle" rowspan="5" align="center" colspan="1">Oral</td><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">CycD1, Ki67, LDH, MMP-9 OGG1, Maspin</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b58-bic-7-2015-025" ref-type="bibr">58</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">IL-1β, IL-6, IL-8, Osteopontin</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b59-bic-7-2015-025" ref-type="bibr">59</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">IL-8, IL-1β, M2BP</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b39-bic-7-2015-025" ref-type="bibr">39</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">TNF-α, IL-1, IL-6, IL-8</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b10-bic-7-2015-025" ref-type="bibr">10</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva, Serum</td><td valign="top" align="left" rowspan="1" colspan="1">IL-1β, IL-6, TNF-α</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b21-bic-7-2015-025" ref-type="bibr">21</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Salivary gland</td><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva, Serum</td><td valign="top" align="left" rowspan="1" colspan="1">FGF2, FGFR1</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b60-bic-7-2015-025" ref-type="bibr">60</xref></td></tr><tr><td valign="middle" rowspan="2" align="center" colspan="1">Head and neck</td><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Serum</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b61-bic-7-2015-025" ref-type="bibr">61</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Serum, Tissue</td><td valign="top" align="left" rowspan="1" colspan="1">IL-1α, IL-6, IL-8, GM-CSF, VEGF, basic FGF</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b62-bic-7-2015-025" ref-type="bibr">62</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Ovarian</td><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Tissue</td><td valign="top" align="left" rowspan="1" colspan="1">c-erbB-2</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b63-bic-7-2015-025" ref-type="bibr">63</xref></td></tr><tr><td valign="middle" rowspan="5" align="center" colspan="1">Breast</td><td valign="top" align="left" rowspan="1" colspan="1">mRNA, Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">CSTA, TPT1, IGF2BP1, GRM1, GRIK1, H6PD, MDM4, S100A8, CA6</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b64-bic-7-2015-025" ref-type="bibr">64</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva, Serum</td><td valign="top" align="left" rowspan="1" colspan="1">CA15-3</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b15-bic-7-2015-025" ref-type="bibr">15</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva, Serum</td><td valign="top" align="left" rowspan="1" colspan="1">c-erbB-2</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b14-bic-7-2015-025" ref-type="bibr">14</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Serum</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6, IL-10</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b65-bic-7-2015-025" ref-type="bibr">65</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Serum</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b66-bic-7-2015-025" ref-type="bibr">66</xref></td></tr><tr><td valign="middle" rowspan="2" align="center" colspan="1">Lung</td><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">EGFR, BRAF, CCNI, FGF19, FRS2, GREB1, LZTS1</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b17-bic-7-2015-025" ref-type="bibr">17</xref></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Protein</td><td valign="top" align="left" rowspan="1" colspan="1">Saliva</td><td valign="top" align="left" rowspan="1" colspan="1">HP, AZGP1, human calprotectin</td><td valign="top" align="left" rowspan="1" colspan="1"><xref rid="b67-bic-7-2015-025" ref-type="bibr">67</xref></td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list></list><tree><noCountry><name sortKey="Ghazali, Nur B" sort="Ghazali, Nur B" uniqKey="Ghazali N" first="Nur B" last="Ghazali">Nur B. Ghazali</name><name sortKey="Idris, Adi" sort="Idris, Adi" uniqKey="Idris A" first="Adi" last="Idris">Adi Idris</name><name sortKey="Koh, David" sort="Koh, David" uniqKey="Koh D" first="David" last="Koh">David Koh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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