Tissue engineering for lateral ridge augmentation with recombinant human bone morphogenetic protein 2 combination therapy: a case report.
Identifieur interne : 005A79 ( Ncbi/Merge ); précédent : 005A78; suivant : 005A80Tissue engineering for lateral ridge augmentation with recombinant human bone morphogenetic protein 2 combination therapy: a case report.
Auteurs : George A. Mandelaris ; Daniel B. Spagnoli ; Alan L. Rosenfeld ; James Mckee ; Mei LuSource :
- The International journal of periodontics & restorative dentistry [ 1945-3388 ]
Descripteurs français
- KwdFr :
- Association thérapeutique, Facteur de croissance transformant bêta (usage thérapeutique), Filet chirurgical, Humains, Implants dentaires, Ingénierie tissulaire, Jeune adulte, Mâchoire partiellement édentée (rééducation et réadaptation), Mâle, Pose d'implant dentaire endo-osseux (), Protéine morphogénétique osseuse de type 2 (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Reconstruction de crête alvéolaire (), Transplantation osseuse.
- MESH :
- rééducation et réadaptation : Mâchoire partiellement édentée.
- usage thérapeutique : Facteur de croissance transformant bêta, Protéine morphogénétique osseuse de type 2, Protéines recombinantes.
- Association thérapeutique, Filet chirurgical, Humains, Implants dentaires, Ingénierie tissulaire, Jeune adulte, Mâle, Pose d'implant dentaire endo-osseux, Reconstruction de crête alvéolaire, Transplantation osseuse.
English descriptors
- KwdEn :
- Alveolar Ridge Augmentation (methods), Bone Morphogenetic Protein 2 (therapeutic use), Bone Transplantation, Combined Modality Therapy, Dental Implantation, Endosseous (methods), Dental Implants, Humans, Jaw, Edentulous, Partially (rehabilitation), Male, Recombinant Proteins (therapeutic use), Surgical Mesh, Tissue Engineering, Transforming Growth Factor beta (therapeutic use), Young Adult.
- MESH :
- chemical , therapeutic use : Bone Morphogenetic Protein 2, Recombinant Proteins, Transforming Growth Factor beta.
- methods : Alveolar Ridge Augmentation, Dental Implantation, Endosseous.
- rehabilitation : Jaw, Edentulous, Partially.
- Bone Transplantation, Combined Modality Therapy, Dental Implants, Humans, Male, Surgical Mesh, Tissue Engineering, Young Adult.
Abstract
This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.
PubMed: 25909520
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pubmed:25909520Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Ridge Augmentation (methods)</term>
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<term>Bone Transplantation</term>
<term>Combined Modality Therapy</term>
<term>Dental Implantation, Endosseous (methods)</term>
<term>Dental Implants</term>
<term>Humans</term>
<term>Jaw, Edentulous, Partially (rehabilitation)</term>
<term>Male</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Surgical Mesh</term>
<term>Tissue Engineering</term>
<term>Transforming Growth Factor beta (therapeutic use)</term>
<term>Young Adult</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Association thérapeutique</term>
<term>Facteur de croissance transformant bêta (usage thérapeutique)</term>
<term>Filet chirurgical</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Ingénierie tissulaire</term>
<term>Jeune adulte</term>
<term>Mâchoire partiellement édentée (rééducation et réadaptation)</term>
<term>Mâle</term>
<term>Pose d'implant dentaire endo-osseux ()</term>
<term>Protéine morphogénétique osseuse de type 2 (usage thérapeutique)</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Reconstruction de crête alvéolaire ()</term>
<term>Transplantation osseuse</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Morphogenetic Protein 2</term>
<term>Recombinant Proteins</term>
<term>Transforming Growth Factor beta</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term>
<term>Dental Implantation, Endosseous</term>
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<keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Jaw, Edentulous, Partially</term>
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<keywords scheme="MESH" qualifier="rééducation et réadaptation" xml:lang="fr"><term>Mâchoire partiellement édentée</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance transformant bêta</term>
<term>Protéine morphogénétique osseuse de type 2</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Bone Transplantation</term>
<term>Combined Modality Therapy</term>
<term>Dental Implants</term>
<term>Humans</term>
<term>Male</term>
<term>Surgical Mesh</term>
<term>Tissue Engineering</term>
<term>Young Adult</term>
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<term>Implants dentaires</term>
<term>Ingénierie tissulaire</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pose d'implant dentaire endo-osseux</term>
<term>Reconstruction de crête alvéolaire</term>
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<front><div type="abstract" xml:lang="en">This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.</div>
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<Abstract><AbstractText>This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.</AbstractText>
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<tree><noCountry><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name>
<name sortKey="Mandelaris, George A" sort="Mandelaris, George A" uniqKey="Mandelaris G" first="George A" last="Mandelaris">George A. Mandelaris</name>
<name sortKey="Mckee, James" sort="Mckee, James" uniqKey="Mckee J" first="James" last="Mckee">James Mckee</name>
<name sortKey="Rosenfeld, Alan L" sort="Rosenfeld, Alan L" uniqKey="Rosenfeld A" first="Alan L" last="Rosenfeld">Alan L. Rosenfeld</name>
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