Nonsurgical Management of Nifedipine Induced Gingival Overgrowth
Identifieur interne : 005393 ( Ncbi/Merge ); précédent : 005392; suivant : 005394Nonsurgical Management of Nifedipine Induced Gingival Overgrowth
Auteurs : George Sam [Inde] ; Staly Chakkalakkal Sebastian [Inde]Source :
- Case Reports in Dentistry [ 2090-6447 ] ; 2014.
Abstract
Drug-induced gingival overgrowth is frequently associated with three particular drugs: phenytoin, cyclosporin, and nifedipine. As gingival enlargement develops, it affects the normal oral hygiene practice and may interfere with masticatory functions. The awareness in the medical community about this possible side effect of nifedipine is less when compared to the effects of phenytoin and cyclosporin. The frequency of gingival enlargement associated with chronic nifedipine therapy remains controversial. Within the group of patients that develop this unwanted effect, there appears to be variability in the extent and severity of the gingival changes. Although gingival inflammation is considered a primary requisite in their development, few cases with minimal or no plaque induced gingival inflammation have also been reported. A case report of gingival overgrowth induced by nifedipine in a patient with good oral hygiene and its nonsurgical management with drug substitution is discussed in this case report.
Url:
DOI: 10.1155/2014/741402
PubMed: 25165585
PubMed Central: 4137614
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<front><div type="abstract" xml:lang="en"><p>Drug-induced gingival overgrowth is frequently associated with three particular drugs: phenytoin, cyclosporin, and nifedipine. As gingival enlargement develops, it affects the normal oral hygiene practice and may interfere with masticatory functions. The awareness in the medical community about this possible side effect of nifedipine is less when compared to the effects of phenytoin and cyclosporin. The frequency of gingival enlargement associated with chronic nifedipine therapy remains controversial. Within the group of patients that develop this unwanted effect, there appears to be variability in the extent and severity of the gingival changes. Although gingival inflammation is considered a primary requisite in their development, few cases with minimal or no plaque induced gingival inflammation have also been reported. A case report of gingival overgrowth induced by nifedipine in a patient with good oral hygiene and its nonsurgical management with drug substitution is discussed in this case report.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Dent</journal-id>
<journal-id journal-id-type="iso-abbrev">Case Rep Dent</journal-id>
<journal-id journal-id-type="publisher-id">CRID</journal-id>
<journal-title-group><journal-title>Case Reports in Dentistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-6447</issn>
<issn pub-type="epub">2090-6455</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
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<article-meta><article-id pub-id-type="pmid">25165585</article-id>
<article-id pub-id-type="pmc">4137614</article-id>
<article-id pub-id-type="doi">10.1155/2014/741402</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Nonsurgical Management of Nifedipine Induced Gingival Overgrowth</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-0442-6060</contrib-id>
<name><surname>Sam</surname>
<given-names>George</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sebastian</surname>
<given-names>Staly Chakkalakkal</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Periodontics, Government Dental College, Kottayam, Kerala, India</aff>
<aff id="I2"><sup>2</sup>
Obstetrics and Gynaecology, Kerala Institute of Medical Sciences, Trivandrum, Kerala, India</aff>
<author-notes><corresp id="cor1">*George Sam: <email>007georgy@gmail.com</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Pablo I. Varela-Centelles</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>3</day>
<month>8</month>
<year>2014</year>
</pub-date>
<volume>2014</volume>
<elocation-id>741402</elocation-id>
<history><date date-type="received"><day>11</day>
<month>5</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>8</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>16</day>
<month>7</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 G. Sam and S. C. Sebastian.</copyright-statement>
<copyright-year>2014</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Drug-induced gingival overgrowth is frequently associated with three particular drugs: phenytoin, cyclosporin, and nifedipine. As gingival enlargement develops, it affects the normal oral hygiene practice and may interfere with masticatory functions. The awareness in the medical community about this possible side effect of nifedipine is less when compared to the effects of phenytoin and cyclosporin. The frequency of gingival enlargement associated with chronic nifedipine therapy remains controversial. Within the group of patients that develop this unwanted effect, there appears to be variability in the extent and severity of the gingival changes. Although gingival inflammation is considered a primary requisite in their development, few cases with minimal or no plaque induced gingival inflammation have also been reported. A case report of gingival overgrowth induced by nifedipine in a patient with good oral hygiene and its nonsurgical management with drug substitution is discussed in this case report.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>(a) Preoperative view. (b) Preoperative view.</p>
</caption>
<graphic xlink:href="CRID2014-741402.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>(a) Postoperative view (2 months after drug substitution). (b) Postoperative view (2 months after drug substitution).</p>
</caption>
<graphic xlink:href="CRID2014-741402.002"></graphic>
</fig>
</floats-group>
</pmc>
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<name sortKey="Sebastian, Staly Chakkalakkal" sort="Sebastian, Staly Chakkalakkal" uniqKey="Sebastian S" first="Staly Chakkalakkal" last="Sebastian">Staly Chakkalakkal Sebastian</name>
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