Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study
Identifieur interne : 005232 ( Ncbi/Merge ); précédent : 005231; suivant : 005233Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study
Auteurs : Harmanpreet Kaur [Canada] ; Hasan Uluda [Canada] ; Tarek El-Bialy [Canada]Source :
- BioMed Research International [ 2314-6133 ] ; 2014.
Abstract
Url:
DOI: 10.1155/2014/426710
PubMed: 24967367
PubMed Central: 4055166
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study</title><author><name sortKey="Kaur, Harmanpreet" sort="Kaur, Harmanpreet" uniqKey="Kaur H" first="Harmanpreet" last="Kaur">Harmanpreet Kaur</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Uluda, Hasan" sort="Uluda, Hasan" uniqKey="Uluda H" first="Hasan" last="Uluda">Hasan Uluda</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="El Bialy, Tarek" sort="El Bialy, Tarek" uniqKey="El Bialy T" first="Tarek" last="El-Bialy">Tarek El-Bialy</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24967367</idno><idno type="pmc">4055166</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055166</idno><idno type="RBID">PMC:4055166</idno><idno type="doi">10.1155/2014/426710</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002885</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002885</idno><idno type="wicri:Area/Pmc/Curation">002885</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002885</idno><idno type="wicri:Area/Pmc/Checkpoint">001506</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001506</idno><idno type="wicri:Area/Ncbi/Merge">005232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study</title><author><name sortKey="Kaur, Harmanpreet" sort="Kaur, Harmanpreet" uniqKey="Kaur H" first="Harmanpreet" last="Kaur">Harmanpreet Kaur</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Uluda, Hasan" sort="Uluda, Hasan" uniqKey="Uluda H" first="Hasan" last="Uluda">Hasan Uluda</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="El Bialy, Tarek" sort="El Bialy, Tarek" uniqKey="El Bialy T" first="Tarek" last="El-Bialy">Tarek El-Bialy</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2E1</nlm:aff><country>Canada</country><wicri:regionArea>Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Objective</italic>. Basic fibroblast growth factor (bFGF) is an important regulator of tissue growth. Previous studies have shown that low intensity pulsed ultrasound (LIPUS) stimulates bone growth. The objective of this study was to evaluate the possible synergetic effect of LIPUS and local injection of nonviral bFGF plasmid DNA (pDNA) on mandibular growth in rats. <italic>Design</italic>. Groups were control, blank pDNA, bFGF pDNA, LIPUS, and bFGF pDNA + LIPUS. Treatments were performed for 28 days. Significant increase was observed in mandibular height and condylar length in LIPUS groups. MicroCT analysis showed significant increase in bone volume fraction in bFGF pDNA + LIPUS group. Histomorphometric analysis showed increased cell count and condylar proliferative and hypertrophic layers widths in bFGF pDNA group. <italic>Results</italic>. Current study showed increased mandibular condylar growth in either bFGF pDNA or LIPUS groups compared to the combined group that showed only increased bone volume fraction. <italic>Conclusion</italic>. It appears that there is an additive effect of bFGF + LIPUS on the mandibular growth.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dimitriou, R" uniqKey="Dimitriou R">R Dimitriou</name></author><author><name sortKey="Jones, E" uniqKey="Jones E">E Jones</name></author><author><name sortKey="Mcgonagle, D" uniqKey="Mcgonagle D">D McGonagle</name></author><author><name sortKey="Giannoudis, Pv" uniqKey="Giannoudis P">PV Giannoudis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thyagarajan, T" uniqKey="Thyagarajan T">T Thyagarajan</name></author><author><name sortKey="Totey, S" uniqKey="Totey S">S Totey</name></author><author><name sortKey="Danton, Mjs" uniqKey="Danton M">MJS Danton</name></author><author><name sortKey="Kulkarni, Ab" uniqKey="Kulkarni A">AB Kulkarni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krueckeberg, Sm" uniqKey="Krueckeberg S">SM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id><journal-id journal-id-type="publisher-id">BMRI</journal-id><journal-title-group><journal-title>BioMed Research International</journal-title></journal-title-group><issn pub-type="ppub">2314-6133</issn><issn pub-type="epub">2314-6141</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24967367</article-id><article-id pub-id-type="pmc">4055166</article-id><article-id pub-id-type="doi">10.1155/2014/426710</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-0539-4219</contrib-id><name><surname>Kaur</surname><given-names>Harmanpreet</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Uludağ</surname><given-names>Hasan</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-4435-5172</contrib-id><name><surname>El-Bialy</surname><given-names>Tarek</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Dentistry, Faculty of Medicine and Dentistry, Medical Science Graduate Program, University of Alberta, Edmonton, AB, Canada T6G 2E1</aff><aff id="I2"><sup>2</sup>Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada T6G 2E1</aff><aff id="I3"><sup>3</sup>Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2E1</aff><author-notes><corresp id="cor1">*Tarek El-Bialy: <email>telbialy@ualberta.ca</email></corresp><fn fn-type="other"><p>Academic Editor: Hagen Schmal</p></fn></author-notes><pub-date pub-type="ppub"><year>2014</year></pub-date><pub-date pub-type="epub"><day>20</day><month>5</month><year>2014</year></pub-date><volume>2014</volume><elocation-id>426710</elocation-id><history><date date-type="received"><day>21</day><month>1</month><year>2014</year></date><date date-type="rev-recd"><day>14</day><month>3</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>4</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Harmanpreet Kaur et al.</copyright-statement><copyright-year>2014</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Objective</italic>. Basic fibroblast growth factor (bFGF) is an important regulator of tissue growth. Previous studies have shown that low intensity pulsed ultrasound (LIPUS) stimulates bone growth. The objective of this study was to evaluate the possible synergetic effect of LIPUS and local injection of nonviral bFGF plasmid DNA (pDNA) on mandibular growth in rats. <italic>Design</italic>. Groups were control, blank pDNA, bFGF pDNA, LIPUS, and bFGF pDNA + LIPUS. Treatments were performed for 28 days. Significant increase was observed in mandibular height and condylar length in LIPUS groups. MicroCT analysis showed significant increase in bone volume fraction in bFGF pDNA + LIPUS group. Histomorphometric analysis showed increased cell count and condylar proliferative and hypertrophic layers widths in bFGF pDNA group. <italic>Results</italic>. Current study showed increased mandibular condylar growth in either bFGF pDNA or LIPUS groups compared to the combined group that showed only increased bone volume fraction. <italic>Conclusion</italic>. It appears that there is an additive effect of bFGF + LIPUS on the mandibular growth.</p></abstract><funding-group><award-group><funding-source>Women and Children's Health Research Institute</funding-source></award-group></funding-group></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>(a) The diagram illustrating the anthropometric points and linear measurements of the mandible (for definition, see <xref ref-type="table" rid="tab1">Table 1</xref>). (b) The anthropometric measurement of the extracted rat mandible with the help of digital vernier caliper.</p></caption><graphic xlink:href="BMRI2014-426710.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Transaxial view of the Micro-CT scan. (a) The region of interest was manually drawn to separate trabecular bone from the cortical bone of the condyle and was analysed later using Micro-CT Analyser (Skyscan, NV, BE). (b) The new bone formation in the bFGF treated group on the mandibular condylar head.</p></caption><graphic xlink:href="BMRI2014-426710.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>The bar chart of the length of the condylar process (A–E) among the five groups showing increase in the length in the LIPUS treated group {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.003"></graphic></fig><fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>The bar chart of the ramal height (A–D) of the mandible among the five groups showing increase in the height of the mandible in LIPUS treated group {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.004"></graphic></fig><fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label><caption><p>The bar chart of the Men-GP (B-C) of the mandible among the five groups showing increase in the height of the mandible in LIPUS treated group {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.005"></graphic></fig><fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label><caption><p>The bar chart of the bone volume fraction of the mandible condyle showing increase in bone volume fraction in the combination group (bFGF + LIPUS) {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.006"></graphic></fig><fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label><caption><p>H&E stained sections of the articular surface of the condyle in the treatment groups seen in 20x magnification. (a) The proliferative layer marked by arrow 1 and the hypertrophic layer marked by arrow 2. (b) Control group. (c) gWiz group. (d) bFGF group (e) LIPUS group. (f) bFGF + LIPUS group.</p></caption><graphic xlink:href="BMRI2014-426710.007"></graphic></fig><fig id="fig8" orientation="portrait" position="float"><label>Figure 8</label><caption><p>The bar chart shows increase in proliferative cell count for the LIPUS treated group {*<italic>P</italic> < 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.008"></graphic></fig><fig id="fig9" orientation="portrait" position="float"><label>Figure 9</label><caption><p>The bar chart depicts the result for the hypertrophic cell count of the condyle showing increase in the cell number in the bFGF treated group {*<italic>P</italic> < 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.009"></graphic></fig><fig id="fig10" orientation="portrait" position="float"><label>Figure 10</label><caption><p>The bar chart depicts the result for the width of the proliferative layer of the condyle showing increase in the width in the bFGF treated group {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.010"></graphic></fig><fig id="fig11" orientation="portrait" position="float"><label>Figure 11</label><caption><p>The bar chart depicts the result for the width of the hypertrophic layer of the condyle showing increase in the width in the bFGF treated group {* = <italic>P</italic> ≤ 0.05}.</p></caption><graphic xlink:href="BMRI2014-426710.011"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Description of the anthropometric points and linear measurements.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th><th align="left" rowspan="1" colspan="1">Description</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Points</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Condylar point (A)</td><td align="left" rowspan="1" colspan="1">The most posterior and superior point on the mandible condyle.</td></tr><tr><td align="left" rowspan="1" colspan="1"> Menton (B)</td><td align="left" rowspan="1" colspan="1">The most inferior point on the mandibular symphysis.</td></tr><tr><td align="left" rowspan="1" colspan="1"> Gonion point (C)</td><td align="left" rowspan="1" colspan="1">The most posterior point on the bony contour of the gonial angle of the mandible.</td></tr><tr><td align="left" rowspan="1" colspan="1"> Gonion tangent point (D)</td><td align="left" rowspan="1" colspan="1">Assuming that the mandible is placed on a plane. The point of the mandibular gonion at its junction with that plane. </td></tr><tr><td align="left" rowspan="1" colspan="1"> Mandibular foramen (E)</td><td align="left" rowspan="1" colspan="1">The point of entry of mandibular nerve and blood vessels into the mandibular canal.</td></tr><tr><td align="left" rowspan="1" colspan="1">Linear measurement</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Menton-condylar point (A-B)</td><td align="left" rowspan="1" colspan="1">Total mandibular length.The distance measured between menton and condylar points. </td></tr><tr><td align="left" rowspan="1" colspan="1"> Menton-gonion point (B-C)</td><td align="left" rowspan="1" colspan="1">Length of mandibular base.The distance measured between menton and gonion points. </td></tr><tr><td align="left" rowspan="1" colspan="1"> Condylar-GoT (A–D)</td><td align="left" rowspan="1" colspan="1">Ramus height.The distance measured between condylar and gonial tangent points. </td></tr><tr><td align="left" rowspan="1" colspan="1"> Condylar process length (A–E)</td><td align="left" rowspan="1" colspan="1">The distance measured between mandibular foramen to condylar points. </td></tr></tbody></table></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Mean and standard deviation of BMD and bone volume.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th><th align="center" rowspan="1" colspan="1">Control</th><th align="center" rowspan="1" colspan="1">gWiz</th><th align="center" rowspan="1" colspan="1">bFGF</th><th align="center" rowspan="1" colspan="1">LIPUS</th><th align="center" rowspan="1" colspan="1">bFGF + LIPUS</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">BMD</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Mean</td><td align="center" rowspan="1" colspan="1">0.0048</td><td align="center" rowspan="1" colspan="1">0.0053</td><td align="center" rowspan="1" colspan="1">0.0078</td><td align="center" rowspan="1" colspan="1">0.0063</td><td align="center" rowspan="1" colspan="1">0.0086</td></tr><tr><td align="left" rowspan="1" colspan="1"> Std dev.</td><td align="center" rowspan="1" colspan="1">0.001</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">0.003</td><td align="center" rowspan="1" colspan="1">0</td><td align="center" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">BVol</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Mean</td><td align="center" rowspan="1" colspan="1">0.0926</td><td align="center" rowspan="1" colspan="1">0.09</td><td align="center" rowspan="1" colspan="1">0.109</td><td align="center" rowspan="1" colspan="1">0.1003</td><td align="center" rowspan="1" colspan="1">0.1069</td></tr><tr><td align="left" rowspan="1" colspan="1"> Std dev.</td><td align="center" rowspan="1" colspan="1">0.017</td><td align="center" rowspan="1" colspan="1">0.038</td><td align="center" rowspan="1" colspan="1">0.006</td><td align="center" rowspan="1" colspan="1">0.021</td><td align="center" rowspan="1" colspan="1">0.008</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kaur, Harmanpreet" sort="Kaur, Harmanpreet" uniqKey="Kaur H" first="Harmanpreet" last="Kaur">Harmanpreet Kaur</name></noRegion><name sortKey="El Bialy, Tarek" sort="El Bialy, Tarek" uniqKey="El Bialy T" first="Tarek" last="El-Bialy">Tarek El-Bialy</name><name sortKey="Uluda, Hasan" sort="Uluda, Hasan" uniqKey="Uluda H" first="Hasan" last="Uluda">Hasan Uluda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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