Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study
Identifieur interne : 004846 ( Ncbi/Merge ); précédent : 004845; suivant : 004847Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study
Auteurs : Dhanraj Muthuveera Ganapathy [Inde] ; Sajeesh Joseph [Inde] ; Padma Ariga [Inde] ; Anand Selvaraj [Inde]Source :
- Dental Research Journal [ 1735-3327 ] ; 2013.
Abstract
Candidal colonization in complete denture wearers is a commonly encountered condition that worsens in the presence of untreated Diabetes Mellitus. The aim of this study was to evaluate the correlation between oral candidiasis in denture-bearing mucosa and elevated blood glucose levels in complete denture wearers and to evaluate the effect of oral hypoglycemic drug therapy in controlling oral candidal colonization in denture-bearing mucosa of complete denture wearers with Type II Diabetes Mellitus.
This prospective observational study involved the participation of 15 complete denture wearers with Type II Diabetes Mellitus. The sample collection was made prior and after oral hypoglycaemic drug intervention, by swabbing the rugal surfaces of palatal mucosa, cultured and the density of the candidal colony formed was analyzed and interpreted as colony forming units (CFU) per mL. The candidal samples CFU and corresponding pre- and post-prandial blood glucose levels were estimated, analyzed and compared using Karl Pearson correlation analysis and paired
The Karl Pearson correlation analysis showed that there was a positive correlation between the blood glucose levels (PPS and FBS) and the candidal colonization (CFU) (
Positive correlation was observed between oral candidiasis in complete denture-bearing mucosa and elevated blood glucose levels and oral hypoglycemic drug therapy has a positive effect in controlling oral candidal colonization in complete denture wearers with Type II Diabetes Mellitus.
Url:
DOI: 10.4103/1735-3327.111806
PubMed: 23878569
PubMed Central: 3714830
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<author><name sortKey="Ganapathy, Dhanraj Muthuveera" sort="Ganapathy, Dhanraj Muthuveera" uniqKey="Ganapathy D" first="Dhanraj Muthuveera" last="Ganapathy">Dhanraj Muthuveera Ganapathy</name>
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<author><name sortKey="Joseph, Sajeesh" sort="Joseph, Sajeesh" uniqKey="Joseph S" first="Sajeesh" last="Joseph">Sajeesh Joseph</name>
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<author><name sortKey="Ariga, Padma" sort="Ariga, Padma" uniqKey="Ariga P" first="Padma" last="Ariga">Padma Ariga</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An <italic>in vivo</italic>
Study</title>
<author><name sortKey="Ganapathy, Dhanraj Muthuveera" sort="Ganapathy, Dhanraj Muthuveera" uniqKey="Ganapathy D" first="Dhanraj Muthuveera" last="Ganapathy">Dhanraj Muthuveera Ganapathy</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai</wicri:regionArea>
<wicri:noRegion>Chennai</wicri:noRegion>
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<author><name sortKey="Joseph, Sajeesh" sort="Joseph, Sajeesh" uniqKey="Joseph S" first="Sajeesh" last="Joseph">Sajeesh Joseph</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai</wicri:regionArea>
<wicri:noRegion>Chennai</wicri:noRegion>
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<author><name sortKey="Ariga, Padma" sort="Ariga, Padma" uniqKey="Ariga P" first="Padma" last="Ariga">Padma Ariga</name>
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<country xml:lang="fr">Inde</country>
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<author><name sortKey="Selvaraj, Anand" sort="Selvaraj, Anand" uniqKey="Selvaraj A" first="Anand" last="Selvaraj">Anand Selvaraj</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
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<wicri:noRegion>Chennai</wicri:noRegion>
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<series><title level="j">Dental Research Journal</title>
<idno type="ISSN">1735-3327</idno>
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<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title>
<p>Candidal colonization in complete denture wearers is a commonly encountered condition that worsens in the presence of untreated Diabetes Mellitus. The aim of this study was to evaluate the correlation between oral candidiasis in denture-bearing mucosa and elevated blood glucose levels in complete denture wearers and to evaluate the effect of oral hypoglycemic drug therapy in controlling oral candidal colonization in denture-bearing mucosa of complete denture wearers with Type II Diabetes Mellitus.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>This prospective observational study involved the participation of 15 complete denture wearers with Type II Diabetes Mellitus. The sample collection was made prior and after oral hypoglycaemic drug intervention, by swabbing the rugal surfaces of palatal mucosa, cultured and the density of the candidal colony formed was analyzed and interpreted as colony forming units (CFU) per mL. The candidal samples CFU and corresponding pre- and post-prandial blood glucose levels were estimated, analyzed and compared using Karl Pearson correlation analysis and paired <italic>t</italic>
-test (α = 0.05).</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>The Karl Pearson correlation analysis showed that there was a positive correlation between the blood glucose levels (PPS and FBS) and the candidal colonization (CFU) (<italic>P</italic>
< 0.05). The mean values of all the variables were analyzed using the paired <italic>t</italic>
-test. There was significant reduction in the mean values of blood glucose levels (<italic>P</italic>
< 0.001) and the mean values of the CFU (<italic>P</italic>
< 0.001) following oral hypoglycemic drug therapy.</p>
</sec>
<sec id="st4"><title>Conclusion:</title>
<p>Positive correlation was observed between oral candidiasis in complete denture-bearing mucosa and elevated blood glucose levels and oral hypoglycemic drug therapy has a positive effect in controlling oral candidal colonization in complete denture wearers with Type II Diabetes Mellitus.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id>
<journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id>
<journal-id journal-id-type="publisher-id">DRJ</journal-id>
<journal-title-group><journal-title>Dental Research Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">1735-3327</issn>
<issn pub-type="epub">2008-0255</issn>
<publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23878569</article-id>
<article-id pub-id-type="pmc">3714830</article-id>
<article-id pub-id-type="publisher-id">DRJ-10-87</article-id>
<article-id pub-id-type="doi">10.4103/1735-3327.111806</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An <italic>in vivo</italic>
Study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ganapathy</surname>
<given-names>Dhanraj Muthuveera</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joseph</surname>
<given-names>Sajeesh</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ariga</surname>
<given-names>Padma</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Selvaraj</surname>
<given-names>Anand</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Department of Prosthodontics, Saveetha Dental College, Saveetha University, Chennai, India</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Dr. M. Dhanraj, Department of Prosthodontics, No. 162, P.H. Road, Saveetha Dental College, Saveetha University, Chennai, India. <email xlink:href="dhanrajmganapathy@yahoo.co.in">dhanrajmganapathy@yahoo.co.in</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Jan-Feb</season>
<year>2013</year>
</pub-date>
<volume>10</volume>
<issue>1</issue>
<fpage>87</fpage>
<lpage>92</lpage>
<history><date date-type="received"><month>2</month>
<year>2012</year>
</date>
<date date-type="accepted"><month>9</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec id="st1"><title>Background:</title>
<p>Candidal colonization in complete denture wearers is a commonly encountered condition that worsens in the presence of untreated Diabetes Mellitus. The aim of this study was to evaluate the correlation between oral candidiasis in denture-bearing mucosa and elevated blood glucose levels in complete denture wearers and to evaluate the effect of oral hypoglycemic drug therapy in controlling oral candidal colonization in denture-bearing mucosa of complete denture wearers with Type II Diabetes Mellitus.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>This prospective observational study involved the participation of 15 complete denture wearers with Type II Diabetes Mellitus. The sample collection was made prior and after oral hypoglycaemic drug intervention, by swabbing the rugal surfaces of palatal mucosa, cultured and the density of the candidal colony formed was analyzed and interpreted as colony forming units (CFU) per mL. The candidal samples CFU and corresponding pre- and post-prandial blood glucose levels were estimated, analyzed and compared using Karl Pearson correlation analysis and paired <italic>t</italic>
-test (α = 0.05).</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>The Karl Pearson correlation analysis showed that there was a positive correlation between the blood glucose levels (PPS and FBS) and the candidal colonization (CFU) (<italic>P</italic>
< 0.05). The mean values of all the variables were analyzed using the paired <italic>t</italic>
-test. There was significant reduction in the mean values of blood glucose levels (<italic>P</italic>
< 0.001) and the mean values of the CFU (<italic>P</italic>
< 0.001) following oral hypoglycemic drug therapy.</p>
</sec>
<sec id="st4"><title>Conclusion:</title>
<p>Positive correlation was observed between oral candidiasis in complete denture-bearing mucosa and elevated blood glucose levels and oral hypoglycemic drug therapy has a positive effect in controlling oral candidal colonization in complete denture wearers with Type II Diabetes Mellitus.</p>
</sec>
</abstract>
<kwd-group><kwd>Candidal colonization</kwd>
<kwd>complete dentures</kwd>
<kwd>diabetes mellitus</kwd>
<kwd>oral hypoglycemic drugs</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Inde</li>
</country>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Ganapathy, Dhanraj Muthuveera" sort="Ganapathy, Dhanraj Muthuveera" uniqKey="Ganapathy D" first="Dhanraj Muthuveera" last="Ganapathy">Dhanraj Muthuveera Ganapathy</name>
</noRegion>
<name sortKey="Ariga, Padma" sort="Ariga, Padma" uniqKey="Ariga P" first="Padma" last="Ariga">Padma Ariga</name>
<name sortKey="Joseph, Sajeesh" sort="Joseph, Sajeesh" uniqKey="Joseph S" first="Sajeesh" last="Joseph">Sajeesh Joseph</name>
<name sortKey="Selvaraj, Anand" sort="Selvaraj, Anand" uniqKey="Selvaraj A" first="Anand" last="Selvaraj">Anand Selvaraj</name>
</country>
</tree>
</affiliations>
</record>
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