Orofacial Dyskinesia
Identifieur interne : 004639 ( Ncbi/Merge ); précédent : 004638; suivant : 004640Orofacial Dyskinesia
Auteurs : Ronald M. KobayashiSource :
- Western Journal of Medicine [ 0093-0415 ] ; 1976.
Abstract
Orofacial or tardive dyskinesias are involuntary repetitive movements of the mouth and face. In most cases, they occur in older psychotic patients who are in institutions and in whom long-term treatment with antipsychotic drugs of the phenothiazine and butyrophenone groups is being carried out. These dyskinesias are frequent in occurrence and characteristically are irreversible. Several biochemical mechanisms have been proposed as causes, including hypersensitivity or partially deneverated brain dopamine receptors and low affinity of the offending drugs for brain muscarinic cholinergic receptors. Clinical therapy has been attempted primarily with drugs that antagonize dopamine receptors or deplete brain dopamine. The benefits of drug treatment have been variable and lack of consistent improvement has been discouraging. Early recognition of dyskinesia should be attempted, and the dose reduced or the drug omitted at the first sign.
Url:
PubMed: 23611
PubMed Central: 1237309
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<front><journal-meta><journal-id journal-id-type="nlm-ta">West J Med</journal-id><journal-title>Western Journal of Medicine</journal-title><issn pub-type="ppub">0093-0415</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23611</article-id><article-id pub-id-type="pmc">1237309</article-id><article-categories><subj-group subj-group-type="heading"><subject>Medical Progress</subject></subj-group></article-categories><title-group><article-title>Orofacial Dyskinesia</article-title><subtitle>Clinical Features, Mechanisms and Drug Therapy</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kobayashi</surname><given-names>Ronald M.</given-names></name><degrees>MD</degrees> </contrib></contrib-group><aff id="af1">Department of Neurosciences, University of California, San Diego, School of Medicine, and Veterans Administration Hospital, San Diego.</aff><pub-date pub-type="ppub"><month>10</month><year>1976</year></pub-date><volume>125</volume><issue>4</issue><fpage>277</fpage><lpage>288</lpage><abstract><p>Orofacial or tardive dyskinesias are involuntary repetitive movements of the mouth and face. In most cases, they occur in older psychotic patients who are in institutions and in whom long-term treatment with antipsychotic drugs of the phenothiazine and butyrophenone groups is being carried out. These dyskinesias are frequent in occurrence and characteristically are irreversible. Several biochemical mechanisms have been proposed as causes, including hypersensitivity or partially deneverated brain dopamine receptors and low affinity of the offending drugs for brain muscarinic cholinergic receptors. Clinical therapy has been attempted primarily with drugs that antagonize dopamine receptors or deplete brain dopamine. The benefits of drug treatment have been variable and lack of consistent improvement has been discouraging. Early recognition of dyskinesia should be attempted, and the dose reduced or the drug omitted at the first sign.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Kobayashi, Ronald M" sort="Kobayashi, Ronald M" uniqKey="Kobayashi R" first="Ronald M." last="Kobayashi">Ronald M. Kobayashi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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