Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of C. albicans, Salivary Flow, and Dry Mouth
Identifieur interne : 004229 ( Ncbi/Merge ); précédent : 004228; suivant : 004230Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of C. albicans, Salivary Flow, and Dry Mouth
Auteurs : Sandra Altarawneh [États-Unis] ; Sompop Bencharit [États-Unis] ; Luisito Mendoza [États-Unis] ; Alice Curran [États-Unis] ; David Barrow [États-Unis] ; Silvana Barros [États-Unis] ; John Preisser [États-Unis] ; Zvi G. Loewy [États-Unis] ; Linda Gendreau [États-Unis] ; Steven Offenbacher [États-Unis]Source :
- Journal of prosthodontics : official journal of the American College of Prosthodontists [ 1059-941X ] ; 2012.
Abstract
Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using 1) exfoliative cytology, 2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and 3) the salivary flow rate and xerostomic symptoms.
A cross-sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton’s classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid-Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (
There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (
In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.
Url:
DOI: 10.1111/j.1532-849X.2012.00906.x
PubMed: 23107189
PubMed Central: 3541428
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<author><name sortKey="Gendreau, Linda" sort="Gendreau, Linda" uniqKey="Gendreau L" first="Linda" last="Gendreau">Linda Gendreau</name>
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<author><name sortKey="Altarawneh, Sandra" sort="Altarawneh, Sandra" uniqKey="Altarawneh S" first="Sandra" last="Altarawneh">Sandra Altarawneh</name>
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<author><name sortKey="Curran, Alice" sort="Curran, Alice" uniqKey="Curran A" first="Alice" last="Curran">Alice Curran</name>
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<author><name sortKey="Barrow, David" sort="Barrow, David" uniqKey="Barrow D" first="David" last="Barrow">David Barrow</name>
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</affiliation>
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<author><name sortKey="Barros, Silvana" sort="Barros, Silvana" uniqKey="Barros S" first="Silvana" last="Barros">Silvana Barros</name>
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<author><name sortKey="Preisser, John" sort="Preisser, John" uniqKey="Preisser J" first="John" last="Preisser">John Preisser</name>
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</affiliation>
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<author><name sortKey="Loewy, Zvi G" sort="Loewy, Zvi G" uniqKey="Loewy Z" first="Zvi G." last="Loewy">Zvi G. Loewy</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York</wicri:cityArea>
</affiliation>
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<author><name sortKey="Gendreau, Linda" sort="Gendreau, Linda" uniqKey="Gendreau L" first="Linda" last="Gendreau">Linda Gendreau</name>
<affiliation wicri:level="2"><nlm:aff id="A7">GlaxoSmithKline, Parsippany, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>GlaxoSmithKline, Parsippany</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill</wicri:cityArea>
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<series><title level="j">Journal of prosthodontics : official journal of the American College of Prosthodontists</title>
<idno type="ISSN">1059-941X</idno>
<idno type="eISSN">1532-849X</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using 1) exfoliative cytology, 2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and 3) the salivary flow rate and xerostomic symptoms.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">A cross-sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton’s classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid-Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (<italic>albicans</italic>
and non-<italic>albicans</italic>
) were determined in salivary samples (expressed as colony-forming units, CFU), as well as from swab samples obtained from denture fitting surfaces, in addition to affected and unaffected mucosa.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (<italic>P</italic>
= 0.02) inflammatory cell counts in DS patients, as compared with smears of healthy denture-wearers. <italic>C. albicans</italic>
was significantly more prevalent in saliva (<italic>P</italic>
= 0.03) and on denture surfaces (<italic>P</italic>
= 0.002) of DS participants, whereas mucosal candidal counts and the presence of cytological hyphae did not show significant difference comparing DS to healthy participants.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9301275</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2519</journal-id>
<journal-id journal-id-type="nlm-ta">J Prosthodont</journal-id>
<journal-id journal-id-type="iso-abbrev">J Prosthodont</journal-id>
<journal-title-group><journal-title>Journal of prosthodontics : official journal of the American College of Prosthodontists</journal-title>
</journal-title-group>
<issn pub-type="ppub">1059-941X</issn>
<issn pub-type="epub">1532-849X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23107189</article-id>
<article-id pub-id-type="pmc">3541428</article-id>
<article-id pub-id-type="doi">10.1111/j.1532-849X.2012.00906.x</article-id>
<article-id pub-id-type="manuscript">NIHMS391194</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Clinical and Histological Findings of Denture Stomatitis as Related to Intraoral Colonization Patterns of <italic>C. albicans</italic>
, Salivary Flow, and Dry Mouth</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>AlTarawneh</surname>
<given-names>Sandra</given-names>
</name>
<degrees>DDS, MS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bencharit</surname>
<given-names>Sompop</given-names>
</name>
<degrees>DDS, MS, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mendoza</surname>
<given-names>Luisito</given-names>
</name>
<degrees>DDS</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Curran</surname>
<given-names>Alice</given-names>
</name>
<degrees>DMD, MS</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barrow</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barros</surname>
<given-names>Silvana</given-names>
</name>
<degrees>DDS, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Preisser</surname>
<given-names>John</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loewy</surname>
<given-names>Zvi G.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gendreau</surname>
<given-names>Linda</given-names>
</name>
<degrees>DDS, MS</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offenbacher</surname>
<given-names>Steven</given-names>
</name>
<degrees>DDS, PhD, MMSc</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Prosthdontics, University of North Carolina School of Dentistry, Chapel Hill, NC</aff>
<aff id="A2"><label>2</label>
Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC</aff>
<aff id="A3"><label>3</label>
Department of Diagnostic Sciences & General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC</aff>
<aff id="A4"><label>4</label>
Department of Dental Research, University of North Carolina School of Dentistry, Chapel Hill, NC</aff>
<aff id="A5"><label>5</label>
Department of Biostatistics, University of North Carolina School of Dentistry, Chapel Hill, NC</aff>
<aff id="A6"><label>6</label>
Department of Pharmaceutical & Biomedical Sciences, Touro College of Pharmacy, New York, NY</aff>
<aff id="A7"><label>7</label>
GlaxoSmithKline, Parsippany, NJ</aff>
<author-notes><corresp id="FN1">Correspondence: Sandra AlTarawneh, UNC SOD, Dept. of Prosthodontics, 330 Brauer Hall, CB# 7450, Chapel Hill, NC 27599. <email>altaraws@dentistry.unc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>10</day>
<month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>10</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>22</volume>
<issue>1</issue>
<fpage>13</fpage>
<lpage>22</lpage>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other oral candidiasis, DS can occur in a healthy person wearing a denture. In this study, we therefore attempt to explore the association between candida, denture, and mucosal tissue using 1) exfoliative cytology, 2) the candidal levels present in saliva, on mucosal tissues and on denture surfaces, and 3) the salivary flow rate and xerostomic symptoms.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">A cross-sectional study enrolled 32 edentulous participants, 17 without DS as controls and 15 with DS (Newton’s classification type II and III). Participants with systemic or other known oral conditions were excluded. Participants completed a xerostomia questionnaire, and salivary flow rates were measured. Samples of unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. UWS was used for fungal culturing. Periodic acid-Schiff (PAS) stain and quantitative exfoliative cytology were performed on samples from affected and unaffected mucosa from each participant. Levels of Candida species (<italic>albicans</italic>
and non-<italic>albicans</italic>
) were determined in salivary samples (expressed as colony-forming units, CFU), as well as from swab samples obtained from denture fitting surfaces, in addition to affected and unaffected mucosa.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There were no significant differences in salivary flow rates, mucosal wetness, or frequency of reported dry mouth comparing participants with and without DS. Exfoliative cytology of mucosal smears demonstrated significantly higher (<italic>P</italic>
= 0.02) inflammatory cell counts in DS patients, as compared with smears of healthy denture-wearers. <italic>C. albicans</italic>
was significantly more prevalent in saliva (<italic>P</italic>
= 0.03) and on denture surfaces (<italic>P</italic>
= 0.002) of DS participants, whereas mucosal candidal counts and the presence of cytological hyphae did not show significant difference comparing DS to healthy participants.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this investigation, we presented a unique group of healthy edentulous patients. This population may reflect the general DS population without systemic or other oral diseases. The prominent etiological factor for DS in this population is the presence of candida in denture and saliva. We found that other factors such as saliva flow/xerostomia, fitting of the denture, and the presence of candida in the mucosa, are less important in this population. Therefore, DS treatments in healthy patients should first focus on sanitization of an existing denture and/or fabrication of a new denture.</p>
</sec>
</abstract>
<kwd-group><kwd>C. <italic>albicans</italic>
</kwd>
<kwd>denture</kwd>
<kwd>hyposalivation</kwd>
<kwd>stomatitis</kwd>
<kwd>exfoliative cytology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>New Jersey</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Altarawneh, Sandra" sort="Altarawneh, Sandra" uniqKey="Altarawneh S" first="Sandra" last="Altarawneh">Sandra Altarawneh</name>
</region>
<name sortKey="Barros, Silvana" sort="Barros, Silvana" uniqKey="Barros S" first="Silvana" last="Barros">Silvana Barros</name>
<name sortKey="Barrow, David" sort="Barrow, David" uniqKey="Barrow D" first="David" last="Barrow">David Barrow</name>
<name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name>
<name sortKey="Curran, Alice" sort="Curran, Alice" uniqKey="Curran A" first="Alice" last="Curran">Alice Curran</name>
<name sortKey="Gendreau, Linda" sort="Gendreau, Linda" uniqKey="Gendreau L" first="Linda" last="Gendreau">Linda Gendreau</name>
<name sortKey="Loewy, Zvi G" sort="Loewy, Zvi G" uniqKey="Loewy Z" first="Zvi G." last="Loewy">Zvi G. Loewy</name>
<name sortKey="Mendoza, Luisito" sort="Mendoza, Luisito" uniqKey="Mendoza L" first="Luisito" last="Mendoza">Luisito Mendoza</name>
<name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name>
<name sortKey="Preisser, John" sort="Preisser, John" uniqKey="Preisser J" first="John" last="Preisser">John Preisser</name>
</country>
</tree>
</affiliations>
</record>
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