Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers
Identifieur interne : 003F34 ( Ncbi/Merge ); précédent : 003F33; suivant : 003F35Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers
Auteurs : Mine Tezal ; Frank A. Scannapieco ; Jean Wactawski-Wende ; Andrew Hyland ; James R. Marshall ; Nestor R. Rigual ; Daniel L. StolerSource :
- Archives of otolaryngology--head & neck surgery [ 0886-4470 ] ; 2012.
Abstract
To determine whether periodontitis is associated with human papillomavirus (HPV) status of head and neck squamous cell carcinoma (HNSCC).
Hospital-based case-control study in a comprehensive cancer center.
Evaluation included all patients diagnosed with incident primary squamous cell carcinoma of the oral cavity, oropharynx, and larynx between 1999 and 2007 for whom tissue samples and dental records were available (N = 124). Patients younger than 21 years and those with a history of cancer were excluded. Periodontitis history was assessed by alveolar bone loss in millimeters from panoramic radiographs by one examiner blinded to cancer status.
The presence of HPV-16 DNA in paraffin-embedded tumor samples was identified by polymerase chain reaction.
The prevalence of HPV-positive HNSCC was 50 of 124 patients (40.3%). A higher proportion of oropharyngeal cancers were HPV-positive (32 of 49 [65.3%]) compared with oral cavity (9 of 31 [29.0%]) and laryngeal (9 of 44 [20.5%]) cancers. Each millimeter of alveolar bone loss was associated with 2.6 times increased odds (odds ratio [OR], 2.61; 95% CI, 1.58-4.30) of HPV-positive tumor status after adjustment for age at diagnosis, sex, and smoking status. The strength of the association was greater among patients with oropharyngeal SCC (OR, 11.70; 95% CI, 2.09-65.53) compared with those with oral cavity SCC (OR,2.32; 95% 0,0.65-8.27) and laryngeal SCC (OR, 3.89; 95% CI, 0.95-15.99).
A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC. This association seems to be stronger among palienLs with oropharyngeal cancer compared with those who have oral cavity or laryngeal SCC.
Url:
DOI: 10.1001/archoto.2012.873
PubMed: 22710409
PubMed Central: 4477511
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers</title><author><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name></author><author><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name></author><author><name sortKey="Marshall, James R" sort="Marshall, James R" uniqKey="Marshall J" first="James R." last="Marshall">James R. Marshall</name></author><author><name sortKey="Rigual, Nestor R" sort="Rigual, Nestor R" uniqKey="Rigual N" first="Nestor R." last="Rigual">Nestor R. Rigual</name></author><author><name sortKey="Stoler, Daniel L" sort="Stoler, Daniel L" uniqKey="Stoler D" first="Daniel L." last="Stoler">Daniel L. Stoler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22710409</idno><idno type="pmc">4477511</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477511</idno><idno type="RBID">PMC:4477511</idno><idno type="doi">10.1001/archoto.2012.873</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002739</idno><idno type="wicri:Area/Pmc/Curation">002739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002739</idno><idno type="wicri:Area/Pmc/Checkpoint">001E05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E05</idno><idno type="wicri:Area/Ncbi/Merge">003F34</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers</title><author><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name></author><author><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name></author><author><name sortKey="Marshall, James R" sort="Marshall, James R" uniqKey="Marshall J" first="James R." last="Marshall">James R. Marshall</name></author><author><name sortKey="Rigual, Nestor R" sort="Rigual, Nestor R" uniqKey="Rigual N" first="Nestor R." last="Rigual">Nestor R. Rigual</name></author><author><name sortKey="Stoler, Daniel L" sort="Stoler, Daniel L" uniqKey="Stoler D" first="Daniel L." last="Stoler">Daniel L. Stoler</name></author></analytic><series><title level="j">Archives of otolaryngology--head & neck surgery</title><idno type="ISSN">0886-4470</idno><idno type="eISSN">1538-361X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To determine whether periodontitis is associated with human papillomavirus (HPV) status of head and neck squamous cell carcinoma (HNSCC).</p></sec><sec id="S2"><title>Design and Setting</title><p id="P2">Hospital-based case-control study in a comprehensive cancer center.</p></sec><sec id="S3"><title>Patients</title><p id="P3">Evaluation included all patients diagnosed with incident primary squamous cell carcinoma of the oral cavity, oropharynx, and larynx between 1999 and 2007 for whom tissue samples and dental records were available (N = 124). Patients younger than 21 years and those with a history of cancer were excluded. Periodontitis history was assessed by alveolar bone loss in millimeters from panoramic radiographs by one examiner blinded to cancer status.</p></sec><sec id="S4"><title>Main Outcome Measure</title><p id="P4">The presence of HPV-16 DNA in paraffin-embedded tumor samples was identified by polymerase chain reaction.</p></sec><sec id="S5"><title>Results</title><p id="P5">The prevalence of HPV-positive HNSCC was 50 of 124 patients (40.3%). A higher proportion of oropharyngeal cancers were HPV-positive (32 of 49 [65.3%]) compared with oral cavity (9 of 31 [29.0%]) and laryngeal (9 of 44 [20.5%]) cancers. Each millimeter of alveolar bone loss was associated with 2.6 times increased odds (odds ratio [OR], 2.61; 95% CI, 1.58-4.30) of HPV-positive tumor status after adjustment for age at diagnosis, sex, and smoking status. The strength of the association was greater among patients with oropharyngeal SCC (OR, 11.70; 95% CI, 2.09-65.53) compared with those with oral cavity SCC (OR,2.32; 95% 0,0.65-8.27) and laryngeal SCC (OR, 3.89; 95% CI, 0.95-15.99).</p></sec><sec id="S6"><title>Conclusions</title><p id="P6">A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC. This association seems to be stronger among palienLs with oropharyngeal cancer compared with those who have oral cavity or laryngeal SCC.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8603209</journal-id><journal-id journal-id-type="pubmed-jr-id">1566</journal-id><journal-id journal-id-type="nlm-ta">Arch Otolaryngol Head Neck Surg</journal-id><journal-id journal-id-type="iso-abbrev">Arch. Otolaryngol. Head Neck Surg.</journal-id><journal-title-group><journal-title>Archives of otolaryngology--head & neck surgery</journal-title></journal-title-group><issn pub-type="ppub">0886-4470</issn><issn pub-type="epub">1538-361X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22710409</article-id><article-id pub-id-type="pmc">4477511</article-id><article-id pub-id-type="doi">10.1001/archoto.2012.873</article-id><article-id pub-id-type="manuscript">NIHMS697951</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tezal</surname><given-names>Mine</given-names></name><degrees>DDS, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Scannapieco</surname><given-names>Frank A.</given-names></name><degrees>DMD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Wactawski-Wende</surname><given-names>Jean</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Hyland</surname><given-names>Andrew</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Marshall</surname><given-names>James R.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Rigual</surname><given-names>Nestor R.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Stoler</surname><given-names>Daniel L.</given-names></name><degrees>PhD</degrees></contrib><aff id="A1">Departments of Oral Diagnostic Sciences, (Dr Tezal), Oral Biology (Drs Tezal and Scannapieco), and Social and Preventive Medicine (Drs Tezal and Wactawski-Wende), State University of New York at Buffalo, and Departments of Cancer Prevention and Population Sciences (Drs Hyland and Marshall), Head and Neck Surgery (Drs Rigual and Stoler), and Cancer Pathology and Prevention (Dr Stoler), Roswell Park Cancer Institute, Buffalo, New York.</aff></contrib-group><author-notes><corresp id="CR1"><bold>Correspondence:</bold> Mine Tezal, DDS, PhD, Department of Oral Diagnostic Sciences, State University of New York at Buffalo, 355 Squire Hall, Buffalo, NY 14214 (<email>mtezal@buffalo.edu</email>).</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>6</month><year>2015</year></pub-date><volume>138</volume><issue>7</issue><fpage>669</fpage><lpage>675</lpage><pmc-comment>elocation-id from pubmed: 10.1001/archoto.2012.873</pmc-comment>
<permissions><copyright-statement>©2012 American Medical Association. All rights reserved</copyright-statement></permissions><abstract><sec id="S1"><title>Objective</title><p id="P1">To determine whether periodontitis is associated with human papillomavirus (HPV) status of head and neck squamous cell carcinoma (HNSCC).</p></sec><sec id="S2"><title>Design and Setting</title><p id="P2">Hospital-based case-control study in a comprehensive cancer center.</p></sec><sec id="S3"><title>Patients</title><p id="P3">Evaluation included all patients diagnosed with incident primary squamous cell carcinoma of the oral cavity, oropharynx, and larynx between 1999 and 2007 for whom tissue samples and dental records were available (N = 124). Patients younger than 21 years and those with a history of cancer were excluded. Periodontitis history was assessed by alveolar bone loss in millimeters from panoramic radiographs by one examiner blinded to cancer status.</p></sec><sec id="S4"><title>Main Outcome Measure</title><p id="P4">The presence of HPV-16 DNA in paraffin-embedded tumor samples was identified by polymerase chain reaction.</p></sec><sec id="S5"><title>Results</title><p id="P5">The prevalence of HPV-positive HNSCC was 50 of 124 patients (40.3%). A higher proportion of oropharyngeal cancers were HPV-positive (32 of 49 [65.3%]) compared with oral cavity (9 of 31 [29.0%]) and laryngeal (9 of 44 [20.5%]) cancers. Each millimeter of alveolar bone loss was associated with 2.6 times increased odds (odds ratio [OR], 2.61; 95% CI, 1.58-4.30) of HPV-positive tumor status after adjustment for age at diagnosis, sex, and smoking status. The strength of the association was greater among patients with oropharyngeal SCC (OR, 11.70; 95% CI, 2.09-65.53) compared with those with oral cavity SCC (OR,2.32; 95% 0,0.65-8.27) and laryngeal SCC (OR, 3.89; 95% CI, 0.95-15.99).</p></sec><sec id="S6"><title>Conclusions</title><p id="P6">A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC. This association seems to be stronger among palienLs with oropharyngeal cancer compared with those who have oral cavity or laryngeal SCC.</p></sec></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name><name sortKey="Marshall, James R" sort="Marshall, James R" uniqKey="Marshall J" first="James R." last="Marshall">James R. Marshall</name><name sortKey="Rigual, Nestor R" sort="Rigual, Nestor R" uniqKey="Rigual N" first="Nestor R." last="Rigual">Nestor R. Rigual</name><name sortKey="Scannapieco, Frank A" sort="Scannapieco, Frank A" uniqKey="Scannapieco F" first="Frank A." last="Scannapieco">Frank A. Scannapieco</name><name sortKey="Stoler, Daniel L" sort="Stoler, Daniel L" uniqKey="Stoler D" first="Daniel L." last="Stoler">Daniel L. Stoler</name><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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