Bisphosphonate-related osteonecrosis of the jaw: the Florence experience
Identifieur interne : 003D17 ( Ncbi/Merge ); précédent : 003D16; suivant : 003D18Bisphosphonate-related osteonecrosis of the jaw: the Florence experience
Auteurs : Alberto Borgioli ; Marco Duvina ; Leila Brancato ; Christian Viviani ; Maria Luisa Brandi ; Paolo TonelliSource :
- Clinical Cases in Mineral and Bone Metabolism [ 1724-8914 ] ; 2007.
Abstract
Url:
PubMed: 22460753
PubMed Central: 2781176
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bisphosphonate-related osteonecrosis of the jaw: the Florence experience</title>
<author><name sortKey="Borgioli, Alberto" sort="Borgioli, Alberto" uniqKey="Borgioli A" first="Alberto" last="Borgioli">Alberto Borgioli</name>
</author>
<author><name sortKey="Duvina, Marco" sort="Duvina, Marco" uniqKey="Duvina M" first="Marco" last="Duvina">Marco Duvina</name>
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<author><name sortKey="Brancato, Leila" sort="Brancato, Leila" uniqKey="Brancato L" first="Leila" last="Brancato">Leila Brancato</name>
</author>
<author><name sortKey="Viviani, Christian" sort="Viviani, Christian" uniqKey="Viviani C" first="Christian" last="Viviani">Christian Viviani</name>
</author>
<author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name>
<affiliation><nlm:aff id="aff_1"></nlm:aff>
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<author><name sortKey="Tonelli, Paolo" sort="Tonelli, Paolo" uniqKey="Tonelli P" first="Paolo" last="Tonelli">Paolo Tonelli</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bisphosphonate-related osteonecrosis of the jaw: the Florence experience</title>
<author><name sortKey="Borgioli, Alberto" sort="Borgioli, Alberto" uniqKey="Borgioli A" first="Alberto" last="Borgioli">Alberto Borgioli</name>
</author>
<author><name sortKey="Duvina, Marco" sort="Duvina, Marco" uniqKey="Duvina M" first="Marco" last="Duvina">Marco Duvina</name>
</author>
<author><name sortKey="Brancato, Leila" sort="Brancato, Leila" uniqKey="Brancato L" first="Leila" last="Brancato">Leila Brancato</name>
</author>
<author><name sortKey="Viviani, Christian" sort="Viviani, Christian" uniqKey="Viviani C" first="Christian" last="Viviani">Christian Viviani</name>
</author>
<author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name>
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<author><name sortKey="Tonelli, Paolo" sort="Tonelli, Paolo" uniqKey="Tonelli P" first="Paolo" last="Tonelli">Paolo Tonelli</name>
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<series><title level="j">Clinical Cases in Mineral and Bone Metabolism</title>
<idno type="ISSN">1724-8914</idno>
<idno type="eISSN">1971-3266</idno>
<imprint><date when="2007">2007</date>
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<front><div type="abstract" xml:lang="en"><p><italic>Aims</italic>
. Bisphosphonates (BPs) are important therapeutic drugs in multiple myeloma and cancers with bone metastases. Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) has been described as a potential side effect of the last generation BPs. The Authors evaluated clinical features, preventing measures and treatment strategies.</p>
<p><italic>Patients and methods</italic>
. The Authors retrospectively analyzed 19 patients affected by malignant cancer in endovenous treatment with BPs. Fourteen patients were treated with zoledronate, 1 with pamidronate and 4 with both drugs for breast cancer (9 patients), multiple myeloma (6 patients), prostatic cancer (3 patients) and colon cancer (1 patient).</p>
<p><italic>Results</italic>
. The lenght of therapy was 5-36 months before osteonecrosis was observed; in 15 patients BRONJ involved the mandible, in 2 the maxilla and in 2 both jaws. The trigger factors were tooth extractions, inadequate removable total denture, basic and advanced surgery, root canal treatment. Ten patients received non-surgical treatment, 7 patients minor surgical procedures and 2 patients a partial maxillectomy. Healing was achieved in all maxillary localization, and in one mandibular localization with partial maxillectomy.</p>
<p><italic>Conclusions</italic>
. Prevention is the best important phase in the management of this pathology. Risk factors are the type of bisphosphonate and the length of exposure, while dental surgical procedures are trigger factors. Conservative treatment seems to be the best way to control BRONJ, but bone resection and soft tissue closure have to be performed when the lesion is refractory to conservative approach.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Cases Miner Bone Metab</journal-id>
<journal-id journal-id-type="publisher-id">22</journal-id>
<journal-title-group><journal-title>Clinical Cases in Mineral and Bone Metabolism</journal-title>
</journal-title-group>
<issn pub-type="ppub">1724-8914</issn>
<issn pub-type="epub">1971-3266</issn>
<publisher><publisher-name>CIC Edizioni Internazionali</publisher-name>
<publisher-loc>Roma, Italyinfo@gruppocic.ithttp://www.gruppocic.com/http://www.ccmbm.com</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">22460753</article-id>
<article-id pub-id-type="pmc">2781176</article-id>
<article-id pub-id-type="pii">2122</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Mini-Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bisphosphonate-related osteonecrosis of the jaw: the Florence experience</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Borgioli</surname>
<given-names>Alberto</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Duvina</surname>
<given-names>Marco</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brancato</surname>
<given-names>Leila</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Viviani</surname>
<given-names>Christian</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Brandi</surname>
<given-names>Maria Luisa</given-names>
</name>
<xref ref-type="aff" rid="aff_1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tonelli</surname>
<given-names>Paolo</given-names>
</name>
</contrib>
</contrib-group>
<aff id="aff_1"><label><sup>1</sup>
</label>
Departments of Oral Surgery and of Internal Medicine University of Florence Medical School, Florence, Italy</aff>
<author-notes><corresp>Address for correspondence: Paolo Tonelli MD, DDS Department of Odontostomatology Viale Morgagni 85, 50134 Florence, Italy Ph. + 39 055 411798 - 415598 Fax. + 39 055 411798 E-mail: <email>p.tonelli@odonto.unifi.it</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Jan-Apr</season>
<year>2007</year>
</pub-date>
<volume>4</volume>
<issue>1</issue>
<fpage>48</fpage>
<lpage>52</lpage>
<permissions><copyright-statement>Copyright © 2007, CIC Edizioni Internazionali</copyright-statement>
<copyright-year>2007</copyright-year>
</permissions>
<abstract><p><italic>Aims</italic>
. Bisphosphonates (BPs) are important therapeutic drugs in multiple myeloma and cancers with bone metastases. Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) has been described as a potential side effect of the last generation BPs. The Authors evaluated clinical features, preventing measures and treatment strategies.</p>
<p><italic>Patients and methods</italic>
. The Authors retrospectively analyzed 19 patients affected by malignant cancer in endovenous treatment with BPs. Fourteen patients were treated with zoledronate, 1 with pamidronate and 4 with both drugs for breast cancer (9 patients), multiple myeloma (6 patients), prostatic cancer (3 patients) and colon cancer (1 patient).</p>
<p><italic>Results</italic>
. The lenght of therapy was 5-36 months before osteonecrosis was observed; in 15 patients BRONJ involved the mandible, in 2 the maxilla and in 2 both jaws. The trigger factors were tooth extractions, inadequate removable total denture, basic and advanced surgery, root canal treatment. Ten patients received non-surgical treatment, 7 patients minor surgical procedures and 2 patients a partial maxillectomy. Healing was achieved in all maxillary localization, and in one mandibular localization with partial maxillectomy.</p>
<p><italic>Conclusions</italic>
. Prevention is the best important phase in the management of this pathology. Risk factors are the type of bisphosphonate and the length of exposure, while dental surgical procedures are trigger factors. Conservative treatment seems to be the best way to control BRONJ, but bone resection and soft tissue closure have to be performed when the lesion is refractory to conservative approach.</p>
</abstract>
<kwd-group><kwd>bisphosphonates</kwd>
<kwd>osteonecrosis of the jaw</kwd>
<kwd>BRONJ</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Borgioli, Alberto" sort="Borgioli, Alberto" uniqKey="Borgioli A" first="Alberto" last="Borgioli">Alberto Borgioli</name>
<name sortKey="Brancato, Leila" sort="Brancato, Leila" uniqKey="Brancato L" first="Leila" last="Brancato">Leila Brancato</name>
<name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name>
<name sortKey="Duvina, Marco" sort="Duvina, Marco" uniqKey="Duvina M" first="Marco" last="Duvina">Marco Duvina</name>
<name sortKey="Tonelli, Paolo" sort="Tonelli, Paolo" uniqKey="Tonelli P" first="Paolo" last="Tonelli">Paolo Tonelli</name>
<name sortKey="Viviani, Christian" sort="Viviani, Christian" uniqKey="Viviani C" first="Christian" last="Viviani">Christian Viviani</name>
</noCountry>
</tree>
</affiliations>
</record>
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