On the Acquisition of Periodontopathic Bacteria by Children from Mothers: A Randomized Double-Masked Placebo-Controlled Trial in Bauru, Brazil
Identifieur interne : 003B63 ( Ncbi/Merge ); précédent : 003B62; suivant : 003B64On the Acquisition of Periodontopathic Bacteria by Children from Mothers: A Randomized Double-Masked Placebo-Controlled Trial in Bauru, Brazil
Auteurs : Walter A. Bretz ; Odila P. S. Rosa ; Salete M. B. Silva ; Patricia M. A. Corby ; Otilia C. Lima ; Marcelo Milanda ; Philippe Hujoel ; Walter J. LoescheSource :
- Suomen hammaslaakarilehti = Finlands tandlakartidning / [HT] [ 0355-4090 ] ; 2006.
Abstract
The purpose of this study was two-fold: 1) to determine the effects of mechanical and chemical modalities treatments on periodontal clinical and microbiological parameters of mothers; and 2) to determine the subsequent colonization of periodontal pathogens in tongue samples from their infants.
A total of 168 mothers met inclusion criteria to participate in a randomized double-masked placebo-controlled clinical trial. Of those, 121 mothers (and their infants) of 158 seen at baseline provided complete data during study protocols from when their infants were 3 months old until the infants were about 2 years old. Treatments consisted of a combination of xylitol chewing gum, fluoride and chlorhexidine varnishes. The control/placebo group received sorbitol chewing gum and placebo varnishes. The effect of these treatments on periodontal clinical and microbiological parameters of mothers and on microbiological parameters of their infants was assessed by generalized estimating equation models.
Microbiological outcomes using the BANA Test were lower for the majority of the visits in the test group when compared to the control/placebo group. These differences, however, were not statistically significant. Similarly, mean PBS results were lower for all follow-up visits for test-group mothers when compared to the control/placebo group’s mothers, but of no statistical significance. Colonization of the tongue in infants by periodontal pathogens as measured by the BANA Test showed no distinct patterns concerning the stability of colonization of periodontal pathogens throughout the study period, albeit slightly superior for the test group.
We have demonstrated that a combined chemical modalities treatment consisting of xylitol chewing gum, fluoride varnish and chlorhexidine varnish was moderately superior to control/placebo treatments on periodontal clinical and microbiological parameters of mothers throughout the study period, but of no statistical significance. Similar results were found for the infants in the test group when compared to infants of the control/placebo groups.
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PubMed: 22267892
PubMed Central: 3261633
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Lima</name></author><author><name sortKey="Milanda, Marcelo" sort="Milanda, Marcelo" uniqKey="Milanda M" first="Marcelo" last="Milanda">Marcelo Milanda</name></author><author><name sortKey="Hujoel, Philippe" sort="Hujoel, Philippe" uniqKey="Hujoel P" first="Philippe" last="Hujoel">Philippe Hujoel</name></author><author><name sortKey="Loesche, Walter J" sort="Loesche, Walter J" uniqKey="Loesche W" first="Walter J." last="Loesche">Walter J. 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Bretz</name></author><author><name sortKey="Rosa, Odila P S" sort="Rosa, Odila P S" uniqKey="Rosa O" first="Odila P. S." last="Rosa">Odila P. S. Rosa</name></author><author><name sortKey="Silva, Salete M B" sort="Silva, Salete M B" uniqKey="Silva S" first="Salete M. B." last="Silva">Salete M. B. Silva</name></author><author><name sortKey="Corby, Patricia M A" sort="Corby, Patricia M A" uniqKey="Corby P" first="Patricia M. A." last="Corby">Patricia M. A. Corby</name></author><author><name sortKey="Lima, Otilia C" sort="Lima, Otilia C" uniqKey="Lima O" first="Otilia C." last="Lima">Otilia C. Lima</name></author><author><name sortKey="Milanda, Marcelo" sort="Milanda, Marcelo" uniqKey="Milanda M" first="Marcelo" last="Milanda">Marcelo Milanda</name></author><author><name sortKey="Hujoel, Philippe" sort="Hujoel, Philippe" uniqKey="Hujoel P" first="Philippe" last="Hujoel">Philippe Hujoel</name></author><author><name sortKey="Loesche, Walter J" sort="Loesche, Walter J" uniqKey="Loesche W" first="Walter J." last="Loesche">Walter J. Loesche</name></author></analytic><series><title level="j">Suomen hammaslaakarilehti = Finlands tandlakartidning / [HT]</title><idno type="ISSN">0355-4090</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">The purpose of this study was two-fold: 1) to determine the effects of mechanical and chemical modalities treatments on periodontal clinical and microbiological parameters of mothers; and 2) to determine the subsequent colonization of periodontal pathogens in tongue samples from their infants.</p></sec><sec id="S2"><title>Design</title><p id="P2">A total of 168 mothers met inclusion criteria to participate in a randomized double-masked placebo-controlled clinical trial. Of those, 121 mothers (and their infants) of 158 seen at baseline provided complete data during study protocols from when their infants were 3 months old until the infants were about 2 years old. Treatments consisted of a combination of xylitol chewing gum, fluoride and chlorhexidine varnishes. The control/placebo group received sorbitol chewing gum and placebo varnishes. The effect of these treatments on periodontal clinical and microbiological parameters of mothers and on microbiological parameters of their infants was assessed by generalized estimating equation models.</p></sec><sec id="S3"><title>Results</title><p id="P3">Microbiological outcomes using the BANA Test were lower for the majority of the visits in the test group when compared to the control/placebo group. These differences, however, were not statistically significant. Similarly, mean PBS results were lower for all follow-up visits for test-group mothers when compared to the control/placebo group’s mothers, but of no statistical significance. Colonization of the tongue in infants by periodontal pathogens as measured by the BANA Test showed no distinct patterns concerning the stability of colonization of periodontal pathogens throughout the study period, albeit slightly superior for the test group.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have demonstrated that a combined chemical modalities treatment consisting of xylitol chewing gum, fluoride varnish and chlorhexidine varnish was moderately superior to control/placebo treatments on periodontal clinical and microbiological parameters of mothers throughout the study period, but of no statistical significance. Similar results were found for the infants in the test group when compared to infants of the control/placebo groups.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8704977</journal-id><journal-id journal-id-type="pubmed-jr-id">7215</journal-id><journal-id journal-id-type="nlm-ta">Suom Hammaslaakarilehti</journal-id><journal-title-group><journal-title>Suomen hammaslaakarilehti = Finlands tandlakartidning / [HT]</journal-title></journal-title-group><issn pub-type="ppub">0355-4090</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22267892</article-id><article-id pub-id-type="pmc">3261633</article-id><article-id pub-id-type="manuscript">NIHMS309705</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>On the Acquisition of Periodontopathic Bacteria by Children from Mothers: A Randomized Double-Masked Placebo-Controlled Trial in Bauru, Brazil</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bretz</surname><given-names>Walter A.</given-names></name><degrees>DDS, Dr. PH</degrees><xref rid="FN1" ref-type="author-notes">*</xref><role>Associate Professor</role><aff id="A1">New York University College of Dentistry, New York, NY, USA</aff></contrib><contrib contrib-type="author"><name><surname>Rosa</surname><given-names>Odila P. S.</given-names></name><degrees>DDS, PhD</degrees><role>Professor</role><aff id="A2">Universidade de São Paulo, Faculdade de Odontologia de Bauru, Bauru, SP, Brazil</aff></contrib><contrib contrib-type="author"><name><surname>Silva</surname><given-names>Salete M. B.</given-names></name><degrees>DDS, PhD</degrees><role>Associate Professor</role><aff id="A3">Universidade de São Paulo, Faculdade de Odontologia de Bauru, Bauru, SP, Brazil</aff></contrib><contrib contrib-type="author"><name><surname>Corby</surname><given-names>Patricia M. A.</given-names></name><degrees>DDS, MS</degrees><role>Assistant Professor</role><aff id="A4">New York University College of Dentistry New York, NY, USA</aff></contrib><contrib contrib-type="author"><name><surname>Lima</surname><given-names>Otilia C.</given-names></name><degrees>MS</degrees><role>Research Associate</role><aff id="A5">University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA</aff></contrib><contrib contrib-type="author"><name><surname>Milanda</surname><given-names>Marcelo</given-names></name><degrees>BS</degrees><role>Research Associate</role><aff id="A6">Universidade de São Paulo, Faculdade de Odontologia de Bauru, Bauru, SP, Brazil</aff></contrib><contrib contrib-type="author"><name><surname>Hujoel</surname><given-names>Philippe</given-names></name><degrees>DDS, PhD</degrees><role>Professor</role><aff id="A7">University of Washington, School of Dentistry, Seattle, WA, USA</aff></contrib><contrib contrib-type="author"><name><surname>Loesche</surname><given-names>Walter J.</given-names></name><degrees>DMD, PhD</degrees><role>Emeritus Professor</role><aff id="A8">University of Michigan, School of Dentistry, Ann Arbor, MI, USA</aff></contrib></contrib-group><author-notes><corresp id="FN1">Walter A. Bretz, New York University College of Dentistry, Department of Cariology & Comprehensive Care, 345 E. 24th Street, New York, NY 10010, Ph: 212-998-9800</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="ppub"><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>1</month><year>2012</year></pub-date><volume>13</volume><issue>Suppl 1</issue><fpage>18</fpage><lpage>24</lpage><abstract><sec id="S1"><title>Objective</title><p id="P1">The purpose of this study was two-fold: 1) to determine the effects of mechanical and chemical modalities treatments on periodontal clinical and microbiological parameters of mothers; and 2) to determine the subsequent colonization of periodontal pathogens in tongue samples from their infants.</p></sec><sec id="S2"><title>Design</title><p id="P2">A total of 168 mothers met inclusion criteria to participate in a randomized double-masked placebo-controlled clinical trial. Of those, 121 mothers (and their infants) of 158 seen at baseline provided complete data during study protocols from when their infants were 3 months old until the infants were about 2 years old. Treatments consisted of a combination of xylitol chewing gum, fluoride and chlorhexidine varnishes. The control/placebo group received sorbitol chewing gum and placebo varnishes. The effect of these treatments on periodontal clinical and microbiological parameters of mothers and on microbiological parameters of their infants was assessed by generalized estimating equation models.</p></sec><sec id="S3"><title>Results</title><p id="P3">Microbiological outcomes using the BANA Test were lower for the majority of the visits in the test group when compared to the control/placebo group. These differences, however, were not statistically significant. Similarly, mean PBS results were lower for all follow-up visits for test-group mothers when compared to the control/placebo group’s mothers, but of no statistical significance. Colonization of the tongue in infants by periodontal pathogens as measured by the BANA Test showed no distinct patterns concerning the stability of colonization of periodontal pathogens throughout the study period, albeit slightly superior for the test group.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have demonstrated that a combined chemical modalities treatment consisting of xylitol chewing gum, fluoride varnish and chlorhexidine varnish was moderately superior to control/placebo treatments on periodontal clinical and microbiological parameters of mothers throughout the study period, but of no statistical significance. Similar results were found for the infants in the test group when compared to infants of the control/placebo groups.</p></sec></abstract><kwd-group><kwd>clinical trials</kwd><kwd>periodontal bacteria</kwd><kwd>xylitol chewing gum</kwd><kwd>sorbitol chewing gum</kwd><kwd>fluoride varnish</kwd><kwd>chlorhexidine varnish</kwd><kwd>mother</kwd><kwd>child</kwd><kwd>randomized clinical trials</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bretz, Walter A" sort="Bretz, Walter A" uniqKey="Bretz W" first="Walter A." last="Bretz">Walter A. Bretz</name><name sortKey="Corby, Patricia M A" sort="Corby, Patricia M A" uniqKey="Corby P" first="Patricia M. A." last="Corby">Patricia M. A. Corby</name><name sortKey="Hujoel, Philippe" sort="Hujoel, Philippe" uniqKey="Hujoel P" first="Philippe" last="Hujoel">Philippe Hujoel</name><name sortKey="Lima, Otilia C" sort="Lima, Otilia C" uniqKey="Lima O" first="Otilia C." last="Lima">Otilia C. Lima</name><name sortKey="Loesche, Walter J" sort="Loesche, Walter J" uniqKey="Loesche W" first="Walter J." last="Loesche">Walter J. Loesche</name><name sortKey="Milanda, Marcelo" sort="Milanda, Marcelo" uniqKey="Milanda M" first="Marcelo" last="Milanda">Marcelo Milanda</name><name sortKey="Rosa, Odila P S" sort="Rosa, Odila P S" uniqKey="Rosa O" first="Odila P. S." last="Rosa">Odila P. S. Rosa</name><name sortKey="Silva, Salete M B" sort="Silva, Salete M B" uniqKey="Silva S" first="Salete M. B." last="Silva">Salete M. B. Silva</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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