Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.
Identifieur interne : 002F37 ( Ncbi/Merge ); précédent : 002F36; suivant : 002F38Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.
Auteurs : Marco Esposito [Royaume-Uni] ; Helen V. Worthington ; Vassiliki Loli ; Paul Coulthard ; Maria Gabriella GrusovinSource :
- The Cochrane database of systematic reviews [ 1469-493X ] ; 2010.
Descripteurs français
- KwdFr :
- Amoxicilline (administration et posologie), Antibactériens (administration et posologie), Antibioprophylaxie (effets indésirables), Calendrier d'administration des médicaments, Essais contrôlés randomisés comme sujet, Humains, Implants dentaires (effets indésirables), Infections bactériennes (), Mâchoire partiellement édentée (), Échec de restauration dentaire.
- MESH :
- administration et posologie : Amoxicilline, Antibactériens.
- effets indésirables : Antibioprophylaxie, Implants dentaires.
- Calendrier d'administration des médicaments, Essais contrôlés randomisés comme sujet, Humains, Infections bactériennes, Mâchoire partiellement édentée, Échec de restauration dentaire.
English descriptors
- KwdEn :
- Amoxicillin (administration & dosage), Anti-Bacterial Agents (administration & dosage), Antibiotic Prophylaxis (adverse effects), Bacterial Infections (prevention & control), Dental Implants (adverse effects), Dental Restoration Failure, Drug Administration Schedule, Humans, Jaw, Edentulous, Partially (surgery), Randomized Controlled Trials as Topic.
- MESH :
- chemical , administration & dosage : Amoxicillin, Anti-Bacterial Agents.
- adverse effects : Antibiotic Prophylaxis, Dental Implants.
- prevention & control : Bacterial Infections.
- surgery : Jaw, Edentulous, Partially.
- Dental Restoration Failure, Drug Administration Schedule, Humans, Randomized Controlled Trials as Topic.
Abstract
Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis, for patients with reduced host-response, when surgery is performed in infected sites, in cases of extensive and prolonged surgical interventions and when large foreign materials are implanted. To minimise infections after dental implant placement various prophylactic systemic antibiotic regimens have been suggested. More recent protocols recommended short term prophylaxis, if antibiotics have to be used. With the administration of antibiotics adverse events may occur, ranging from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.
DOI: 10.1002/14651858.CD004152.pub3
PubMed: 20614437
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</title><author><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester, UK, M15 6FH.</nlm:affiliation><orgName type="university">Université de Manchester</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Worthington, Helen V" sort="Worthington, Helen V" uniqKey="Worthington H" first="Helen V" last="Worthington">Helen V. Worthington</name></author><author><name sortKey="Loli, Vassiliki" sort="Loli, Vassiliki" uniqKey="Loli V" first="Vassiliki" last="Loli">Vassiliki Loli</name></author><author><name sortKey="Coulthard, Paul" sort="Coulthard, Paul" uniqKey="Coulthard P" first="Paul" last="Coulthard">Paul Coulthard</name></author><author><name sortKey="Grusovin, Maria Gabriella" sort="Grusovin, Maria Gabriella" uniqKey="Grusovin M" first="Maria Gabriella" last="Grusovin">Maria Gabriella Grusovin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20614437</idno><idno type="pmid">20614437</idno><idno type="doi">10.1002/14651858.CD004152.pub3</idno><idno type="wicri:Area/PubMed/Corpus">001884</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001884</idno><idno type="wicri:Area/PubMed/Curation">001884</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001884</idno><idno type="wicri:Area/PubMed/Checkpoint">001884</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001884</idno><idno type="wicri:Area/Ncbi/Merge">002F37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</title><author><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester, UK, M15 6FH.</nlm:affiliation><orgName type="university">Université de Manchester</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Worthington, Helen V" sort="Worthington, Helen V" uniqKey="Worthington H" first="Helen V" last="Worthington">Helen V. Worthington</name></author><author><name sortKey="Loli, Vassiliki" sort="Loli, Vassiliki" uniqKey="Loli V" first="Vassiliki" last="Loli">Vassiliki Loli</name></author><author><name sortKey="Coulthard, Paul" sort="Coulthard, Paul" uniqKey="Coulthard P" first="Paul" last="Coulthard">Paul Coulthard</name></author><author><name sortKey="Grusovin, Maria Gabriella" sort="Grusovin, Maria Gabriella" uniqKey="Grusovin M" first="Maria Gabriella" last="Grusovin">Maria Gabriella Grusovin</name></author></analytic><series><title level="j">The Cochrane database of systematic reviews</title><idno type="eISSN">1469-493X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amoxicillin (administration & dosage)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Antibiotic Prophylaxis (adverse effects)</term><term>Bacterial Infections (prevention & control)</term><term>Dental Implants (adverse effects)</term><term>Dental Restoration Failure</term><term>Drug Administration Schedule</term><term>Humans</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amoxicilline (administration et posologie)</term><term>Antibactériens (administration et posologie)</term><term>Antibioprophylaxie (effets indésirables)</term><term>Calendrier d'administration des médicaments</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Implants dentaires (effets indésirables)</term><term>Infections bactériennes ()</term><term>Mâchoire partiellement édentée ()</term><term>Échec de restauration dentaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Amoxicillin</term><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Amoxicilline</term><term>Antibactériens</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antibiotic Prophylaxis</term><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antibioprophylaxie</term><term>Implants dentaires</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dental Restoration Failure</term><term>Drug Administration Schedule</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Calendrier d'administration des médicaments</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Infections bactériennes</term><term>Mâchoire partiellement édentée</term><term>Échec de restauration dentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis, for patients with reduced host-response, when surgery is performed in infected sites, in cases of extensive and prolonged surgical interventions and when large foreign materials are implanted. To minimise infections after dental implant placement various prophylactic systemic antibiotic regimens have been suggested. More recent protocols recommended short term prophylaxis, if antibiotics have to be used. With the administration of antibiotics adverse events may occur, ranging from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20614437</PMID><DateCompleted><Year>2010</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1469-493X</ISSN><JournalIssue CitedMedium="Internet"><Issue>7</Issue><PubDate><Year>2010</Year><Month>Jul</Month><Day>07</Day></PubDate></JournalIssue><Title>The Cochrane database of systematic reviews</Title><ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation></Journal><ArticleTitle>Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.</ArticleTitle><Pagination><MedlinePgn>CD004152</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/14651858.CD004152.pub3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indicated for patients at risk of infectious endocarditis, for patients with reduced host-response, when surgery is performed in infected sites, in cases of extensive and prolonged surgical interventions and when large foreign materials are implanted. To minimise infections after dental implant placement various prophylactic systemic antibiotic regimens have been suggested. More recent protocols recommended short term prophylaxis, if antibiotics have to be used. With the administration of antibiotics adverse events may occur, ranging from diarrhoea to life-threatening allergic reactions. Another major concern associated with the widespread use of antibiotics is the selection of antibiotic-resistant bacteria. The use of prophylactic antibiotics in implant dentistry is controversial.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess the beneficial or harmful effects of systemic prophylactic antibiotics at dental implant placement versus no antibiotic/placebo administration and, if antibiotics are of benefit, to find which type, dosage and duration is the most effective.</AbstractText><AbstractText Label="SEARCH STRATEGY" NlmCategory="METHODS">The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched up to 2nd June 2010. Several dental journals were handsearched. There were no language restrictions.</AbstractText><AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Randomised controlled clinical trials (RCTs) with a follow up of at least 3 months comparing the administration of various prophylactic antibiotic regimens versus no antibiotics to patients undergoing dental implant placement. Outcome measures were prosthesis failures, implant failures, postoperative infections and adverse events (gastrointestinal, hypersensitivity, etc).</AbstractText><AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">Screening of eligible studies, assessment of the methodological quality of the trials and data extraction were conducted in duplicate and independently by two review authors. Results were expressed as random-effects models using risk ratios (RRs) for dichotomous outcomes with 95% confidence intervals (CIs). Heterogeneity was to be investigated including both clinical and methodological factors.</AbstractText><AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">Four RCTs were identified: three comparing 2 g of preoperative amoxicillin versus placebo (927 patients) and the other comparing 1 g of preoperative amoxicillin plus 500 mg 4 times a day for 2 days versus no antibiotics (80 patients). The meta-analyses of the four trials showed a statistically significant higher number of patients experiencing implant failures in the group not receiving antibiotics: RR = 0.40 (95% CI 0.19 to 0.84). The number needed to treat (NNT) to prevent one patient having an implant failure is 33 (95% CI 17 to 100), based on a patient implant failure rate of 5% in patients not receiving antibiotics. The other outcomes were not statistically significant, and only two minor adverse events were recorded, one in the placebo group.</AbstractText><AbstractText Label="AUTHORS' CONCLUSIONS" NlmCategory="CONCLUSIONS">There is some evidence suggesting that 2 g of amoxicillin given orally 1 hour preoperatively significantly reduce failures of dental implants placed in ordinary conditions. No significant adverse events were reported. It might be sensible to suggest the use of a single dose of 2 g prophylactic amoxicillin prior to dental implant placement. It is still unknown whether postoperative antibiotics are beneficial, and which is the most effective antibiotic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Esposito</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Higher Cambridge Street, Manchester, UK, M15 6FH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Worthington</LastName><ForeName>Helen V</ForeName><Initials>HV</Initials></Author><Author ValidYN="Y"><LastName>Loli</LastName><ForeName>Vassiliki</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Coulthard</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Grusovin</LastName><ForeName>Maria Gabriella</ForeName><Initials>MG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cochrane Database Syst Rev</MedlineTA><NlmUniqueID>100909747</NlmUniqueID><ISSNLinking>1361-6137</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>804826J2HU</RegistryNumber><NameOfSubstance UI="D000658">Amoxicillin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Tex Dent J. 2012 Dec;129(12):1276</RefSource><PMID Version="1">23431909</PMID></CommentsCorrections><CommentsCorrections RefType="UpdateIn"><RefSource>Cochrane Database Syst Rev. 2013;7:CD004152</RefSource><PMID Version="1">23904048</PMID></CommentsCorrections><CommentsCorrections RefType="UpdateOf"><RefSource>Cochrane Database Syst Rev. 2008;(3):CD004152</RefSource><PMID Version="1">18646101</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000658" MajorTopicYN="N">Amoxicillin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019072" MajorTopicYN="Y">Antibiotic Prophylaxis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019232" MajorTopicYN="N">Dental Restoration Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>23</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20614437</ArticleId><ArticleId IdType="doi">10.1002/14651858.CD004152.pub3</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><noCountry><name sortKey="Coulthard, Paul" sort="Coulthard, Paul" uniqKey="Coulthard P" first="Paul" last="Coulthard">Paul Coulthard</name><name sortKey="Grusovin, Maria Gabriella" sort="Grusovin, Maria Gabriella" uniqKey="Grusovin M" first="Maria Gabriella" last="Grusovin">Maria Gabriella Grusovin</name><name sortKey="Loli, Vassiliki" sort="Loli, Vassiliki" uniqKey="Loli V" first="Vassiliki" last="Loli">Vassiliki Loli</name><name sortKey="Worthington, Helen V" sort="Worthington, Helen V" uniqKey="Worthington H" first="Helen V" last="Worthington">Helen V. Worthington</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Esposito, Marco" sort="Esposito, Marco" uniqKey="Esposito M" first="Marco" last="Esposito">Marco Esposito</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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