Pretreatment organ function in patients with advanced head and neck cancer: clinical outcome measures and patients' views
Identifieur interne : 002A14 ( Ncbi/Merge ); précédent : 002A13; suivant : 002A15Pretreatment organ function in patients with advanced head and neck cancer: clinical outcome measures and patients' views
Auteurs : Lisette Van Der Molen [Pays-Bas] ; Maya A. Van Rossum [Pays-Bas] ; Annemieke H. Ackerstaff [Pays-Bas] ; Ludi E. Smeele [Pays-Bas] ; Coen Rn Rasch [Pays-Bas] ; Frans Jm Hilgers [Pays-Bas]Source :
- BMC Ear, Nose, and Throat Disorders [ 1472-6815 ] ; 2009.
Abstract
Aim of this study is to thoroughly assess pretreatment organ function in advanced head and neck cancer through various clinical outcome measures and patients' views.
A comprehensive, multidimensional assessment was used, that included quality of life, swallowing, mouth opening, and weight changes. Fifty-five patients with stage III-IV disease were entered in this study prior to organ preserving (chemoradiation) treatment.
All patients showed pretreatment abnormalities or problems, identified by one or more of the outcome measures. Most frequent problems concerned swallowing, pain, and weight loss. Interestingly, clinical outcome measures and patients' perception did no always concur. E.g. videofluoroscopy identified aspiration and laryngeal penetration in 18% of the patients, whereas only 7 patients (13%) perceived this as problematic; only 2 out of 7 patients with objective trismus actually perceived trismus.
The assessment identified several problems already pre-treatment, in this patient population. A thorough assessment of both clinical measures and patients' views appears to be necessary to gain insight in all (perceived) pre-existing functional and quality of life problems.
Url:
DOI: 10.1186/1472-6815-9-10
PubMed: 19912667
PubMed Central: 2779790
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Van Rossum</name><affiliation wicri:level="3"><nlm:aff id="I2">Department of Ear, Nose, Throat, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ear, Nose, Throat, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ackerstaff, Annemieke H" sort="Ackerstaff, Annemieke H" uniqKey="Ackerstaff A" first="Annemieke H" last="Ackerstaff">Annemieke H. Ackerstaff</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Smeele, Ludi E" sort="Smeele, Ludi E" uniqKey="Smeele L" first="Ludi E" last="Smeele">Ludi E. Smeele</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Rasch, Coen Rn" sort="Rasch, Coen Rn" uniqKey="Rasch C" first="Coen Rn" last="Rasch">Coen Rn Rasch</name><affiliation wicri:level="3"><nlm:aff id="I3">Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hilgers, Frans Jm" sort="Hilgers, Frans Jm" uniqKey="Hilgers F" first="Frans Jm" last="Hilgers">Frans Jm Hilgers</name><affiliation wicri:level="4"><nlm:aff id="I4">Institute of Phonetic Sciences, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Phonetic Sciences, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I5">Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Academic Medical Centre/University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19912667</idno><idno type="pmc">2779790</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779790</idno><idno type="RBID">PMC:2779790</idno><idno type="doi">10.1186/1472-6815-9-10</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002164</idno><idno type="wicri:Area/Pmc/Curation">002164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002164</idno><idno type="wicri:Area/Pmc/Checkpoint">002512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002512</idno><idno type="wicri:Area/Ncbi/Merge">002A14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pretreatment organ function in patients with advanced head and neck cancer: clinical outcome measures and patients' views</title><author><name sortKey="Van Der Molen, Lisette" sort="Van Der Molen, Lisette" uniqKey="Van Der Molen L" first="Lisette" last="Van Der Molen">Lisette Van Der Molen</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Rossum, Maya A" sort="Van Rossum, Maya A" uniqKey="Van Rossum M" first="Maya A" last="Van Rossum">Maya A. Van Rossum</name><affiliation wicri:level="3"><nlm:aff id="I2">Department of Ear, Nose, Throat, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ear, Nose, Throat, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ackerstaff, Annemieke H" sort="Ackerstaff, Annemieke H" uniqKey="Ackerstaff A" first="Annemieke H" last="Ackerstaff">Annemieke H. Ackerstaff</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Smeele, Ludi E" sort="Smeele, Ludi E" uniqKey="Smeele L" first="Ludi E" last="Smeele">Ludi E. Smeele</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Rasch, Coen Rn" sort="Rasch, Coen Rn" uniqKey="Rasch C" first="Coen Rn" last="Rasch">Coen Rn Rasch</name><affiliation wicri:level="3"><nlm:aff id="I3">Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hilgers, Frans Jm" sort="Hilgers, Frans Jm" uniqKey="Hilgers F" first="Frans Jm" last="Hilgers">Frans Jm Hilgers</name><affiliation wicri:level="4"><nlm:aff id="I4">Institute of Phonetic Sciences, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Institute of Phonetic Sciences, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="I5">Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Academic Medical Centre/University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author></analytic><series><title level="j">BMC Ear, Nose, and Throat Disorders</title><idno type="eISSN">1472-6815</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Aim of this study is to thoroughly assess pretreatment organ function in advanced head and neck cancer through various clinical outcome measures and patients' views.</p></sec><sec><title>Methods</title><p>A comprehensive, multidimensional assessment was used, that included quality of life, swallowing, mouth opening, and weight changes. Fifty-five patients with stage III-IV disease were entered in this study prior to organ preserving (chemoradiation) treatment.</p></sec><sec><title>Results</title><p>All patients showed pretreatment abnormalities or problems, identified by one or more of the outcome measures. Most frequent problems concerned swallowing, pain, and weight loss. Interestingly, clinical outcome measures and patients' perception did no always concur. E.g. videofluoroscopy identified aspiration and laryngeal penetration in 18% of the patients, whereas only 7 patients (13%) perceived this as problematic; only 2 out of 7 patients with objective trismus actually perceived trismus.</p></sec><sec><title>Conclusion</title><p>The assessment identified several problems already pre-treatment, in this patient population. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Ear Nose Throat Disord</journal-id><journal-id journal-id-type="iso-abbrev">BMC Ear Nose Throat Disord</journal-id><journal-title-group><journal-title>BMC Ear, Nose, and Throat Disorders</journal-title></journal-title-group><issn pub-type="epub">1472-6815</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19912667</article-id><article-id pub-id-type="pmc">2779790</article-id><article-id pub-id-type="publisher-id">1472-6815-9-10</article-id><article-id pub-id-type="doi">10.1186/1472-6815-9-10</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Pretreatment organ function in patients with advanced head and neck cancer: clinical outcome measures and patients' views</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>van der Molen</surname><given-names>Lisette</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>l.vd.molen@nki.nl</email></contrib><contrib contrib-type="author" id="A2"><name><surname>van Rossum</surname><given-names>Maya A</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>M.A.van_Rossum@lumc.nl</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Ackerstaff</surname><given-names>Annemieke H</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>a.ackerstaff@nki.nl</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Smeele</surname><given-names>Ludi E</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>l.smeele@nki.nl</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Rasch</surname><given-names>Coen RN</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>c.rasch@nki.nl</email></contrib><contrib contrib-type="author" corresp="yes" id="A6"><name><surname>Hilgers</surname><given-names>Frans JM</given-names></name><xref ref-type="aff" rid="I4">4</xref><xref ref-type="aff" rid="I5">5</xref><email>f.hilgers@nki.nl</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Head and Neck Oncology & Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="I2"><label>2</label>Department of Ear, Nose, Throat, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="I3"><label>3</label>Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="I4"><label>4</label>Institute of Phonetic Sciences, University of Amsterdam, Amsterdam, The Netherlands</aff><aff id="I5"><label>5</label>Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands</aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2009</year></pub-date><volume>9</volume><fpage>10</fpage><lpage>10</lpage><history><date date-type="received"><day>5</day><month>5</month><year>2009</year></date><date date-type="accepted"><day>15</day><month>11</month><year>2009</year></date></history><permissions><copyright-statement>Copyright ©2009 van der Molen et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2009</copyright-year><copyright-holder>van der Molen et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.biomedcentral.com/1472-6815/9/10"></self-uri><abstract><sec><title>Background</title><p>Aim of this study is to thoroughly assess pretreatment organ function in advanced head and neck cancer through various clinical outcome measures and patients' views.</p></sec><sec><title>Methods</title><p>A comprehensive, multidimensional assessment was used, that included quality of life, swallowing, mouth opening, and weight changes. Fifty-five patients with stage III-IV disease were entered in this study prior to organ preserving (chemoradiation) treatment.</p></sec><sec><title>Results</title><p>All patients showed pretreatment abnormalities or problems, identified by one or more of the outcome measures. Most frequent problems concerned swallowing, pain, and weight loss. Interestingly, clinical outcome measures and patients' perception did no always concur. E.g. videofluoroscopy identified aspiration and laryngeal penetration in 18% of the patients, whereas only 7 patients (13%) perceived this as problematic; only 2 out of 7 patients with objective trismus actually perceived trismus.</p></sec><sec><title>Conclusion</title><p>The assessment identified several problems already pre-treatment, in this patient population. A thorough assessment of both clinical measures and patients' views appears to be necessary to gain insight in all (perceived) pre-existing functional and quality of life problems.</p></sec></abstract></article-meta></front></pmc><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Leyde</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Der Molen, Lisette" sort="Van Der Molen, Lisette" uniqKey="Van Der Molen L" first="Lisette" last="Van Der Molen">Lisette Van Der Molen</name></region><name sortKey="Ackerstaff, Annemieke H" sort="Ackerstaff, Annemieke H" uniqKey="Ackerstaff A" first="Annemieke H" last="Ackerstaff">Annemieke H. Ackerstaff</name><name sortKey="Hilgers, Frans Jm" sort="Hilgers, Frans Jm" uniqKey="Hilgers F" first="Frans Jm" last="Hilgers">Frans Jm Hilgers</name><name sortKey="Hilgers, Frans Jm" sort="Hilgers, Frans Jm" uniqKey="Hilgers F" first="Frans Jm" last="Hilgers">Frans Jm Hilgers</name><name sortKey="Rasch, Coen Rn" sort="Rasch, Coen Rn" uniqKey="Rasch C" first="Coen Rn" last="Rasch">Coen Rn Rasch</name><name sortKey="Smeele, Ludi E" sort="Smeele, Ludi E" uniqKey="Smeele L" first="Ludi E" last="Smeele">Ludi E. Smeele</name><name sortKey="Van Rossum, Maya A" sort="Van Rossum, Maya A" uniqKey="Van Rossum M" first="Maya A" last="Van Rossum">Maya A. Van Rossum</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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