Local immune alterations in oral mucosa of the edentulous patients; possible cause of teeth loss?
Identifieur interne : 002708 ( Ncbi/Merge ); précédent : 002707; suivant : 002709Local immune alterations in oral mucosa of the edentulous patients; possible cause of teeth loss?
Auteurs : Sabina Zurac [Roumanie] ; Mihaela Girtan ; Luciana Lavric ; G. Petsakos ; Florica St Niceanu ; Alexandra Bastian ; R. Andrei ; Cristina Popp ; Elisabeta LabaSource :
- Romanian journal of internal medicine = Revue roumaine de medecine interne [ 1220-4749 ] ; 2008.
Descripteurs français
- KwdFr :
- Bouche édentée (anatomopathologie), Bouche édentée (immunologie), Glandes salivaires (immunologie), Humains, Inflammation (anatomopathologie), Lymphocytes T CD4+ (anatomopathologie), Lymphocytes T CD8+ (anatomopathologie), Muqueuse de la bouche (anatomopathologie), Muqueuse de la bouche (immunologie), Plasmocytes (anatomopathologie), Études cas-témoins.
- MESH :
- anatomopathologie : Bouche édentée, Inflammation, Lymphocytes T CD4+, Lymphocytes T CD8+, Muqueuse de la bouche, Plasmocytes.
- immunologie : Bouche édentée, Glandes salivaires, Muqueuse de la bouche.
- Humains, Études cas-témoins.
English descriptors
- KwdEn :
- CD4-Positive T-Lymphocytes (pathology), CD8-Positive T-Lymphocytes (pathology), Case-Control Studies, Humans, Inflammation (pathology), Mouth Mucosa (immunology), Mouth Mucosa (pathology), Mouth, Edentulous (immunology), Mouth, Edentulous (pathology), Plasma Cells (pathology), Salivary Glands (immunology).
- MESH :
- immunology : Mouth Mucosa, Mouth, Edentulous, Salivary Glands.
- pathology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Inflammation, Mouth Mucosa, Mouth, Edentulous, Plasma Cells.
- Case-Control Studies, Humans.
Abstract
Edentulous patients represent a difficult group of patients, especially in those cases when restorative prostheses are tempted on few remaining elements that eventually will be lost.
PubMed: 19366085
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pubmed:19366085Le document en format XML
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Petsakos</name></author><author><name sortKey="St Niceanu, Florica" sort="St Niceanu, Florica" uniqKey="St Niceanu F" first="Florica" last="St Niceanu">Florica St Niceanu</name></author><author><name sortKey="Bastian, Alexandra" sort="Bastian, Alexandra" uniqKey="Bastian A" first="Alexandra" last="Bastian">Alexandra Bastian</name></author><author><name sortKey="Andrei, R" sort="Andrei, R" uniqKey="Andrei R" first="R" last="Andrei">R. Andrei</name></author><author><name sortKey="Popp, Cristina" sort="Popp, Cristina" uniqKey="Popp C" first="Cristina" last="Popp">Cristina Popp</name></author><author><name sortKey="Laba, Elisabeta" sort="Laba, Elisabeta" uniqKey="Laba E" first="Elisabeta" last="Laba">Elisabeta Laba</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:19366085</idno><idno type="pmid">19366085</idno><idno type="wicri:Area/PubMed/Corpus">002289</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002289</idno><idno type="wicri:Area/PubMed/Curation">002289</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002289</idno><idno type="wicri:Area/PubMed/Checkpoint">002289</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002289</idno><idno type="wicri:Area/Ncbi/Merge">002708</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Local immune alterations in oral mucosa of the edentulous patients; possible cause of teeth loss?</title><author><name sortKey="Zurac, Sabina" sort="Zurac, Sabina" uniqKey="Zurac S" first="Sabina" last="Zurac">Sabina Zurac</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Colentina University Hospital, Bucharest, Romania. sabina_zurac@yahoo.com</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Pathology, Colentina University Hospital, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Girtan, Mihaela" sort="Girtan, Mihaela" uniqKey="Girtan M" first="Mihaela" last="Girtan">Mihaela Girtan</name></author><author><name sortKey="Lavric, Luciana" sort="Lavric, Luciana" uniqKey="Lavric L" first="Luciana" last="Lavric">Luciana Lavric</name></author><author><name sortKey="Petsakos, G" sort="Petsakos, G" uniqKey="Petsakos G" first="G" last="Petsakos">G. Petsakos</name></author><author><name sortKey="St Niceanu, Florica" sort="St Niceanu, Florica" uniqKey="St Niceanu F" first="Florica" last="St Niceanu">Florica St Niceanu</name></author><author><name sortKey="Bastian, Alexandra" sort="Bastian, Alexandra" uniqKey="Bastian A" first="Alexandra" last="Bastian">Alexandra Bastian</name></author><author><name sortKey="Andrei, R" sort="Andrei, R" uniqKey="Andrei R" first="R" last="Andrei">R. Andrei</name></author><author><name sortKey="Popp, Cristina" sort="Popp, Cristina" uniqKey="Popp C" first="Cristina" last="Popp">Cristina Popp</name></author><author><name sortKey="Laba, Elisabeta" sort="Laba, Elisabeta" uniqKey="Laba E" first="Elisabeta" last="Laba">Elisabeta Laba</name></author></analytic><series><title level="j">Romanian journal of internal medicine = Revue roumaine de medecine interne</title><idno type="ISSN">1220-4749</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4-Positive T-Lymphocytes (pathology)</term><term>CD8-Positive T-Lymphocytes (pathology)</term><term>Case-Control Studies</term><term>Humans</term><term>Inflammation (pathology)</term><term>Mouth Mucosa (immunology)</term><term>Mouth Mucosa (pathology)</term><term>Mouth, Edentulous (immunology)</term><term>Mouth, Edentulous (pathology)</term><term>Plasma Cells (pathology)</term><term>Salivary Glands (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Bouche édentée (anatomopathologie)</term><term>Bouche édentée (immunologie)</term><term>Glandes salivaires (immunologie)</term><term>Humains</term><term>Inflammation (anatomopathologie)</term><term>Lymphocytes T CD4+ (anatomopathologie)</term><term>Lymphocytes T CD8+ (anatomopathologie)</term><term>Muqueuse de la bouche (anatomopathologie)</term><term>Muqueuse de la bouche (immunologie)</term><term>Plasmocytes (anatomopathologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bouche édentée</term><term>Inflammation</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Muqueuse de la bouche</term><term>Plasmocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Bouche édentée</term><term>Glandes salivaires</term><term>Muqueuse de la bouche</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Mouth Mucosa</term><term>Mouth, Edentulous</term><term>Salivary Glands</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Inflammation</term><term>Mouth Mucosa</term><term>Mouth, Edentulous</term><term>Plasma Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Edentulous patients represent a difficult group of patients, especially in those cases when restorative prostheses are tempted on few remaining elements that eventually will be lost.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19366085</PMID><DateCompleted><Year>2009</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2009</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1220-4749</ISSN><JournalIssue CitedMedium="Print"><Volume>46</Volume><Issue>3</Issue><PubDate><Year>2008</Year></PubDate></JournalIssue><Title>Romanian journal of internal medicine = Revue roumaine de medecine interne</Title><ISOAbbreviation>Rom J Intern Med</ISOAbbreviation></Journal><ArticleTitle>Local immune alterations in oral mucosa of the edentulous patients; possible cause of teeth loss?</ArticleTitle><Pagination><MedlinePgn>249-53</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">Edentulous patients represent a difficult group of patients, especially in those cases when restorative prostheses are tempted on few remaining elements that eventually will be lost.</AbstractText><AbstractText Label="MATERIAL AND METHOD" NlmCategory="METHODS">We performed a comparative histopathological and immunohistochemical (IHC) analysis of 20 oral mucosa biopsies in total edentulous patients (15 cases - group A) and ofnontumoral mucosa in oncologic patients (5 cases - group B, control).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In group A the inflammatory infiltrate was dominated by the presence of numerous plasma cells (80%) and in 60% of the cases more numerous T cells than B cells were identified. We noticed various aspects of inflammatory infiltrate distribution in cases with epithelial ulceration (either CD8+ T cells intraepithelial and CD4+ T cells beneath the epithelium and perivascular or both CD4+ and CD8+ T cells in both lamina propria and intraepithelial location). 5 of seven cases which included salivary gland tissue revealed moderately to severe inflammatory infiltrate consisting of lymphocytes and plasma cells with lymphoepithelial lesion stage 1 aspects (71.42%). The control group (group B) presented plasma cell inflammatory infiltrate in one case (20%). None of the control cases had lymphoepithelial-like lesions within the salivary tissue.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Presence of intraepithelial T citotoxic cells (CD8+) is correlated with presence of ulceration of the alveolar crest covering mucosa in the edentulous patients. Lymphoepithelial-like lesions of the minor salivary tissue in edentulous patients suggest an autoimmune response in local mucosa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zurac</LastName><ForeName>Sabina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Colentina University Hospital, Bucharest, Romania. sabina_zurac@yahoo.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girtan</LastName><ForeName>Mihaela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lavric</LastName><ForeName>Luciana</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Petsakos</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Stăniceanu</LastName><ForeName>Florica</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bastian</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Andrei</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Popp</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Laba</LastName><ForeName>Elisabeta</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Rom J Intern Med</MedlineTA><NlmUniqueID>9304507</NlmUniqueID><ISSNLinking>1220-4749</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009061" MajorTopicYN="N">Mouth Mucosa</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010950" MajorTopicYN="N">Plasma Cells</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012469" MajorTopicYN="N">Salivary Glands</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>4</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>5</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19366085</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Roumanie</li></country></list><tree><noCountry><name sortKey="Andrei, R" sort="Andrei, R" uniqKey="Andrei R" first="R" last="Andrei">R. Andrei</name><name sortKey="Bastian, Alexandra" sort="Bastian, Alexandra" uniqKey="Bastian A" first="Alexandra" last="Bastian">Alexandra Bastian</name><name sortKey="Girtan, Mihaela" sort="Girtan, Mihaela" uniqKey="Girtan M" first="Mihaela" last="Girtan">Mihaela Girtan</name><name sortKey="Laba, Elisabeta" sort="Laba, Elisabeta" uniqKey="Laba E" first="Elisabeta" last="Laba">Elisabeta Laba</name><name sortKey="Lavric, Luciana" sort="Lavric, Luciana" uniqKey="Lavric L" first="Luciana" last="Lavric">Luciana Lavric</name><name sortKey="Petsakos, G" sort="Petsakos, G" uniqKey="Petsakos G" first="G" last="Petsakos">G. Petsakos</name><name sortKey="Popp, Cristina" sort="Popp, Cristina" uniqKey="Popp C" first="Cristina" last="Popp">Cristina Popp</name><name sortKey="St Niceanu, Florica" sort="St Niceanu, Florica" uniqKey="St Niceanu F" first="Florica" last="St Niceanu">Florica St Niceanu</name></noCountry><country name="Roumanie"><noRegion><name sortKey="Zurac, Sabina" sort="Zurac, Sabina" uniqKey="Zurac S" first="Sabina" last="Zurac">Sabina Zurac</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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