Periodontal disease, but not edentulism, is independently associated with increased plasma fibrinogen levels. Results from a population-based study.
Identifieur interne : 001409 ( Ncbi/Merge ); précédent : 001408; suivant : 001410Periodontal disease, but not edentulism, is independently associated with increased plasma fibrinogen levels. Results from a population-based study.
Auteurs : Christian Schwahn [Allemagne] ; Henry Völzke ; Daniel M. Robinson ; Jan Luedemann ; Olaf Bernhardt ; Dietmar Gesch ; Ulrich John ; Thomas KocherSource :
- Thrombosis and haemostasis [ 0340-6245 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Bouche édentée (sang), Cholestérol LDL (métabolisme), Consommation d'alcool, Facteurs de l'âge, Facteurs sexuels, Facteurs temps, Femelle, Fibrinogène (biosynthèse), Fibrinogène (métabolisme), Humains, Indice de masse corporelle, Maladies cardiovasculaires (sang), Maladies parodontales (sang), Modèles logistiques, Mâle, Odds ratio, Sujet âgé.
- MESH :
- biosynthèse : Fibrinogène.
- métabolisme : Cholestérol LDL, Fibrinogène.
- sang : Bouche édentée, Maladies cardiovasculaires, Maladies parodontales.
- Adulte, Adulte d'âge moyen, Consommation d'alcool, Facteurs de l'âge, Facteurs sexuels, Facteurs temps, Femelle, Humains, Indice de masse corporelle, Modèles logistiques, Mâle, Odds ratio, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Alcohol Drinking, Body Mass Index, Cardiovascular Diseases (blood), Cholesterol, LDL (metabolism), Female, Fibrinogen (biosynthesis), Fibrinogen (metabolism), Humans, Logistic Models, Male, Middle Aged, Mouth, Edentulous (blood), Odds Ratio, Periodontal Diseases (blood), Sex Factors, Time Factors.
- MESH :
- chemical , biosynthesis : Fibrinogen.
- chemical , metabolism : Cholesterol, LDL, Fibrinogen.
- blood : Cardiovascular Diseases, Mouth, Edentulous, Periodontal Diseases.
- Adult, Age Factors, Aged, Alcohol Drinking, Body Mass Index, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Sex Factors, Time Factors.
Abstract
The systemic response to periodontal disease was analyzed in the cross-sectional Study of Health in Pomerania (SHIP). The completed data of 2,738 subjects aged 20 to 59 years were used for logistic regression analysis with an increased plasma fibrinogen level (> or =3.25 g/L according to Clauss) as the dependent variable. Participants were divided into four groups according to the number of periodontal pockets > or =4 mm (0, 1-7, 8-14, > or =15 pocketing). An additional group comprised the 52 edentulous subjects. The adjusted odds ratio (OR) of > or =15 periodontal pockets for increased plasma fibrinogen levels was 1.88 (95% CI: 1.25-2.83). Edentulism per se was not associated with increased plasma fibrinogen levels but was contained in a two-way interaction with the number of cigarettes/day in current smokers (p = 0.031). For edentulous nonsmokers the adjusted OR was 1.10 (95% CI: 0.51-2.39). Furthermore, body mass index, the interaction between gender and body mass index, serum LDL cholesterol, medication, the interaction between LDL cholesterol and medication, aspirin, smoking, school education, chronic bronchitis, and the interaction between alcohol consumption and chronic gastritis were associated with plasma fibrinogen levels. Our results show that periodontal disease but not edentulism per se is associated with an increased plasma fibrinogen level.
DOI: 10.1160/TH04-02-0092
PubMed: 15269819
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pubmed:15269819Le document en format XML
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The completed data of 2,738 subjects aged 20 to 59 years were used for logistic regression analysis with an increased plasma fibrinogen level (> or =3.25 g/L according to Clauss) as the dependent variable. Participants were divided into four groups according to the number of periodontal pockets > or =4 mm (0, 1-7, 8-14, > or =15 pocketing). An additional group comprised the 52 edentulous subjects. The adjusted odds ratio (OR) of > or =15 periodontal pockets for increased plasma fibrinogen levels was 1.88 (95% CI: 1.25-2.83). Edentulism per se was not associated with increased plasma fibrinogen levels but was contained in a two-way interaction with the number of cigarettes/day in current smokers (p = 0.031). For edentulous nonsmokers the adjusted OR was 1.10 (95% CI: 0.51-2.39). Furthermore, body mass index, the interaction between gender and body mass index, serum LDL cholesterol, medication, the interaction between LDL cholesterol and medication, aspirin, smoking, school education, chronic bronchitis, and the interaction between alcohol consumption and chronic gastritis were associated with plasma fibrinogen levels. Our results show that periodontal disease but not edentulism per se is associated with an increased plasma fibrinogen level.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15269819</PMID><DateCompleted><Year>2005</Year><Month>02</Month><Day>15</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6245</ISSN><JournalIssue CitedMedium="Print"><Volume>92</Volume><Issue>2</Issue><PubDate><Year>2004</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Thrombosis and haemostasis</Title><ISOAbbreviation>Thromb. Haemost.</ISOAbbreviation></Journal><ArticleTitle>Periodontal disease, but not edentulism, is independently associated with increased plasma fibrinogen levels. Results from a population-based study.</ArticleTitle><Pagination><MedlinePgn>244-52</MedlinePgn></Pagination><Abstract><AbstractText>The systemic response to periodontal disease was analyzed in the cross-sectional Study of Health in Pomerania (SHIP). The completed data of 2,738 subjects aged 20 to 59 years were used for logistic regression analysis with an increased plasma fibrinogen level (> or =3.25 g/L according to Clauss) as the dependent variable. Participants were divided into four groups according to the number of periodontal pockets > or =4 mm (0, 1-7, 8-14, > or =15 pocketing). An additional group comprised the 52 edentulous subjects. The adjusted odds ratio (OR) of > or =15 periodontal pockets for increased plasma fibrinogen levels was 1.88 (95% CI: 1.25-2.83). Edentulism per se was not associated with increased plasma fibrinogen levels but was contained in a two-way interaction with the number of cigarettes/day in current smokers (p = 0.031). For edentulous nonsmokers the adjusted OR was 1.10 (95% CI: 0.51-2.39). Furthermore, body mass index, the interaction between gender and body mass index, serum LDL cholesterol, medication, the interaction between LDL cholesterol and medication, aspirin, smoking, school education, chronic bronchitis, and the interaction between alcohol consumption and chronic gastritis were associated with plasma fibrinogen levels. Our results show that periodontal disease but not edentulism per se is associated with an increased plasma fibrinogen level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schwahn</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Dentistry, Ernst Moritz Arndt University, Greifswald, Germany. schwahn@uni-greifswald.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völzke</LastName><ForeName>Henry</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Luedemann</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bernhardt</LastName><ForeName>Olaf</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Gesch</LastName><ForeName>Dietmar</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>John</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Kocher</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Thromb Haemost</MedlineTA><NlmUniqueID>7608063</NlmUniqueID><ISSNLinking>0340-6245</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>9001-32-5</RegistryNumber><NameOfSubstance UI="D005340">Fibrinogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000428" MajorTopicYN="N">Alcohol Drinking</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008078" MajorTopicYN="N">Cholesterol, LDL</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005340" MajorTopicYN="N">Fibrinogen</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010510" MajorTopicYN="N">Periodontal Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>7</Month><Day>23</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>2</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>7</Month><Day>23</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15269819</ArticleId><ArticleId IdType="doi">10.1160/TH04-02-0092</ArticleId><ArticleId IdType="pii">04080244</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bernhardt, Olaf" sort="Bernhardt, Olaf" uniqKey="Bernhardt O" first="Olaf" last="Bernhardt">Olaf Bernhardt</name><name sortKey="Gesch, Dietmar" sort="Gesch, Dietmar" uniqKey="Gesch D" first="Dietmar" last="Gesch">Dietmar Gesch</name><name sortKey="John, Ulrich" sort="John, Ulrich" uniqKey="John U" first="Ulrich" last="John">Ulrich John</name><name sortKey="Kocher, Thomas" sort="Kocher, Thomas" uniqKey="Kocher T" first="Thomas" last="Kocher">Thomas Kocher</name><name sortKey="Luedemann, Jan" sort="Luedemann, Jan" uniqKey="Luedemann J" first="Jan" last="Luedemann">Jan Luedemann</name><name sortKey="Robinson, Daniel M" sort="Robinson, Daniel M" uniqKey="Robinson D" first="Daniel M" last="Robinson">Daniel M. Robinson</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Schwahn, Christian" sort="Schwahn, Christian" uniqKey="Schwahn C" first="Christian" last="Schwahn">Christian Schwahn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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