Osteonecrosis of Maxilla Secondary to Bisphosphonate Therapy: A Case Report
Identifieur interne : 005A23 ( Ncbi/Curation ); précédent : 005A22; suivant : 005A24Osteonecrosis of Maxilla Secondary to Bisphosphonate Therapy: A Case Report
Auteurs : Trupti Kolur ; Sanjiv C. Nair ; Balasubramanya KumarSource :
- Journal of Maxillofacial & Oral Surgery [ 0972-8279 ] ; 2011.
Abstract
Bisphosphonate chemotherapy is commonly used in the treatment of bone diseases such as osteoporosis, Paget disease, and multiple myeloma and to limit bone pain and hypercalcemia associated with malignant metastatic bone lesions. The introduction of bisphosphonate therapy has improved the quality of life in a vast majority of patients. However, since 2003 a growing number of reports have described necrotic bone lesions (bisphosphonate—associated Osteonecrosis of the jaw [BR-ONJ]) a bone lesion affecting maxillofacial bones in patients who have received high dosage chemotherapy with intravenous bisphosphonate therapy especially when the patient undergoes subsequent dental procedures.
Sequential removal of sequestra as required seems to be the current conservative approach, but if large-volume debridement becomes necessary, removal of the bone sequestrum with minimal epithelial manipulation associated with topical and systemic antibiotics seem to be the treatment modality of choice. In our case, surgical salvage was performed successfully for BR-ONJ. Our experience indicates that with appropriate technique, primary surgical treatment may offer benefit to selected patients with BR-ONJ.
Url:
DOI: 10.1007/s12663-011-0284-z
PubMed: 25838669
PubMed Central: 4379275
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000938
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000938
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002115
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005A23
Links to Exploration step
PMC:4379275Curation
No country items
Trupti Kolur<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Osteonecrosis of Maxilla Secondary to Bisphosphonate Therapy: A Case Report</title>
<author><name sortKey="Kolur, Trupti" sort="Kolur, Trupti" uniqKey="Kolur T" first="Trupti" last="Kolur">Trupti Kolur</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nair, Sanjiv C" sort="Nair, Sanjiv C" uniqKey="Nair S" first="Sanjiv C." last="Nair">Sanjiv C. Nair</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kumar, Balasubramanya" sort="Kumar, Balasubramanya" uniqKey="Kumar B" first="Balasubramanya" last="Kumar">Balasubramanya Kumar</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25838669</idno>
<idno type="pmc">4379275</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379275</idno>
<idno type="RBID">PMC:4379275</idno>
<idno type="doi">10.1007/s12663-011-0284-z</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000938</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000938</idno>
<idno type="wicri:Area/Pmc/Curation">000938</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000938</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002115</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002115</idno>
<idno type="wicri:Area/Ncbi/Merge">005A23</idno>
<idno type="wicri:Area/Ncbi/Curation">005A23</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Osteonecrosis of Maxilla Secondary to Bisphosphonate Therapy: A Case Report</title>
<author><name sortKey="Kolur, Trupti" sort="Kolur, Trupti" uniqKey="Kolur T" first="Trupti" last="Kolur">Trupti Kolur</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nair, Sanjiv C" sort="Nair, Sanjiv C" uniqKey="Nair S" first="Sanjiv C." last="Nair">Sanjiv C. Nair</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kumar, Balasubramanya" sort="Kumar, Balasubramanya" uniqKey="Kumar B" first="Balasubramanya" last="Kumar">Balasubramanya Kumar</name>
<affiliation><nlm:aff id="Aff1">Bhagwan Mahaveer Jain Hospital, Bangalore, Karnataka</nlm:aff>
<wicri:noCountry code="subfield">Karnataka</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Maxillofacial & Oral Surgery</title>
<idno type="ISSN">0972-8279</idno>
<idno type="eISSN">0974-942X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Bisphosphonate chemotherapy is commonly used in the treatment of bone diseases such as osteoporosis, Paget disease, and multiple myeloma and to limit bone pain and hypercalcemia associated with malignant metastatic bone lesions. The introduction of bisphosphonate therapy has improved the quality of life in a vast majority of patients. However, since 2003 a growing number of reports have described necrotic bone lesions (bisphosphonate—associated Osteonecrosis of the jaw [BR-ONJ]) a bone lesion affecting maxillofacial bones in patients who have received high dosage chemotherapy with intravenous bisphosphonate therapy especially when the patient undergoes subsequent dental procedures.</p>
<p>Sequential removal of sequestra as required seems to be the current conservative approach, but if large-volume debridement becomes necessary, removal of the bone sequestrum with minimal epithelial manipulation associated with topical and systemic antibiotics seem to be the treatment modality of choice. In our case, surgical salvage was performed successfully for BR-ONJ. Our experience indicates that with appropriate technique, primary surgical treatment may offer benefit to selected patients with BR-ONJ.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005A23 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 005A23 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:4379275 |texte= Osteonecrosis of Maxilla Secondary to Bisphosphonate Therapy: A Case Report }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:25838669" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |