Periodontitis in Pregnant Baboons: Systemic Inflammation and Adaptive Immune Responses and Pregnancy Outcomes in a Baboon Model
Identifieur interne : 004698 ( Ncbi/Curation ); précédent : 004697; suivant : 004699Periodontitis in Pregnant Baboons: Systemic Inflammation and Adaptive Immune Responses and Pregnancy Outcomes in a Baboon Model
Auteurs : Jeffrey L. Ebersole [États-Unis] ; Stanley C. Holt [États-Unis] ; David Cappelli [États-Unis]Source :
- Journal of periodontal research [ 0022-3484 ] ; 2013.
Abstract
Chronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. This study describes the relationship of patterns of systemic inflammatory mediators and IgG antibody to 20 oral bacteria in pregnant female baboons (
Url:
DOI: 10.1111/jre.12099
PubMed: 23710643
PubMed Central: 3969847
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002583
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002583
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001862
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004698
Links to Exploration step
PMC:3969847Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Periodontitis in Pregnant Baboons: Systemic Inflammation and Adaptive Immune Responses and Pregnancy Outcomes in a Baboon Model</title>
<author><name sortKey="Ebersole, Jeffrey L" sort="Ebersole, Jeffrey L" uniqKey="Ebersole J" first="Jeffrey L." last="Ebersole">Jeffrey L. Ebersole</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Oral Health Research, College of Dentistry, University of Kentucky, 1055 V.A. Drive, Lexington, KY 40536</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Center for Oral Health Research, College of Dentistry, University of Kentucky, 1055 V.A. Drive, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holt, Stanley C" sort="Holt, Stanley C" uniqKey="Holt S" first="Stanley C." last="Holt">Stanley C. Holt</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Retired, Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Retired, Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cappelli, David" sort="Cappelli, David" uniqKey="Cappelli D" first="David" last="Cappelli">David Cappelli</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Comprehensive Dentistry, The University of Texas Health Science Center at San Antonio School of Dental Medicine, 7703 Floyd Curl Dr., San Antonio, TX 78230</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Comprehensive Dentistry, The University of Texas Health Science Center at San Antonio School of Dental Medicine, 7703 Floyd Curl Dr., San Antonio</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23710643</idno>
<idno type="pmc">3969847</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969847</idno>
<idno type="RBID">PMC:3969847</idno>
<idno type="doi">10.1111/jre.12099</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002583</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002583</idno>
<idno type="wicri:Area/Pmc/Curation">002583</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002583</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001862</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001862</idno>
<idno type="wicri:Area/Ncbi/Merge">004698</idno>
<idno type="wicri:Area/Ncbi/Curation">004698</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Periodontitis in Pregnant Baboons: Systemic Inflammation and Adaptive Immune Responses and Pregnancy Outcomes in a Baboon Model</title>
<author><name sortKey="Ebersole, Jeffrey L" sort="Ebersole, Jeffrey L" uniqKey="Ebersole J" first="Jeffrey L." last="Ebersole">Jeffrey L. Ebersole</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Center for Oral Health Research, College of Dentistry, University of Kentucky, 1055 V.A. Drive, Lexington, KY 40536</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
<wicri:cityArea>Center for Oral Health Research, College of Dentistry, University of Kentucky, 1055 V.A. Drive, Lexington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holt, Stanley C" sort="Holt, Stanley C" uniqKey="Holt S" first="Stanley C." last="Holt">Stanley C. Holt</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Retired, Department of Microbiology, The Forsyth Institute, Cambridge, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Retired, Department of Microbiology, The Forsyth Institute, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cappelli, David" sort="Cappelli, David" uniqKey="Cappelli D" first="David" last="Cappelli">David Cappelli</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Comprehensive Dentistry, The University of Texas Health Science Center at San Antonio School of Dental Medicine, 7703 Floyd Curl Dr., San Antonio, TX 78230</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Comprehensive Dentistry, The University of Texas Health Science Center at San Antonio School of Dental Medicine, 7703 Floyd Curl Dr., San Antonio</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of periodontal research</title>
<idno type="ISSN">0022-3484</idno>
<idno type="eISSN">1600-0765</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Chronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. This study describes the relationship of patterns of systemic inflammatory mediators and IgG antibody to 20 oral bacteria in pregnant female baboons (<italic>Papio anubis</italic>
) coupled with clinical features of ligature-induced periodontitis, as risk indicators for adverse pregnancy outcomes. Animals showing a preterm delivery and/or low birth weight newborns, as well as those pregnancies resulting in spontaneous abortion, stillbirth, or fetal demise were tabulated as adverse pregnancy outcomes. A significantly greater frequency of the periodontitis group neonates had a low birth weight (18.1%; <italic>p</italic>
=0.008) and decreased gestational age (9.8%). Spontaneous abortion/stillbirth/fetal demise were increased in the periodontitis (8.7%) versus the control group (3.8%) (<italic>p</italic>
=0.054). The baseline oral clinical presentation of the experimental animals did not relate to the adverse pregnancy outcomes. Animals with the greatest extent/severity of periodontitis progression during the initial ½ of gestation (ie. to mid-pregnancy) had the greatest risk for adverse pregnancy outcomes. Baseline biological parameters indicating historical responses of the animals to periodontal challenge demonstrated individual variation in selected mediators, some of which became more differential during ligature-induced periodontitis. The relationship of clinical parameters to systemic inflammatory responses was consistent with a temporal contribution to adverse pregnancy outcomes in a subset of the animals. These results support a link between periodontitis and adverse pregnancy outcomes in the baboons and provide a prospective experimental model for delineating the biologic parameters that contribute to a causal relationship between chronic oral infections and birth events.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004698 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 004698 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:3969847 |texte= Periodontitis in Pregnant Baboons: Systemic Inflammation and Adaptive Immune Responses and Pregnancy Outcomes in a Baboon Model }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:23710643" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |