Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials
Identifieur interne : 004692 ( Ncbi/Curation ); précédent : 004691; suivant : 004693Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials
Auteurs : Xinbo Sun [États-Unis] ; Zhengbing Cao [États-Unis] ; Chih-Ko Yeh [États-Unis] ; Yuyu Sun [États-Unis]Source :
- Colloids and surfaces. B, Biointerfaces [ 0927-7765 ] ; 2013.
Abstract
Colonization and biofilm-formation of
Url:
DOI: 10.1016/j.colsurfb.2013.04.043
PubMed: 23708753
PubMed Central: 4004173
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<author><name sortKey="Sun, Yuyu" sort="Sun, Yuyu" uniqKey="Sun Y" first="Yuyu" last="Sun">Yuyu Sun</name>
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-vinyl-2-pyrrolidinone)-grafted denture materials</title>
<author><name sortKey="Sun, Xinbo" sort="Sun, Xinbo" uniqKey="Sun X" first="Xinbo" last="Sun">Xinbo Sun</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Medetech Development Corporation, 12527 Mukilteo Speedway STE 103, Lynnwood, WA 98087</nlm:aff>
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<author><name sortKey="Cao, Zhengbing" sort="Cao, Zhengbing" uniqKey="Cao Z" first="Zhengbing" last="Cao">Zhengbing Cao</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Medetech Development Corporation, 12527 Mukilteo Speedway STE 103, Lynnwood, WA 98087</nlm:aff>
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<author><name sortKey="Yeh, Chih Ko" sort="Yeh, Chih Ko" uniqKey="Yeh C" first="Chih-Ko" last="Yeh">Chih-Ko Yeh</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, and Geriatric Research, Education and Clinical Center, Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78229-4404</nlm:aff>
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<idno type="ISSN">0927-7765</idno>
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<front><div type="abstract" xml:lang="en"><p id="P2">Colonization and biofilm-formation of <italic>Candida</italic>
species on denture surfaces cause <italic>Candida</italic>
-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(<italic>N</italic>
-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, <italic>N</italic>
-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (<italic>N</italic>
-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be “washed out” (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.</p>
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