Fractal dimension evaluation of cone beam computed tomography in patients with bisphosphonate-associated osteonecrosis
Identifieur interne : 003981 ( Ncbi/Curation ); précédent : 003980; suivant : 003982Fractal dimension evaluation of cone beam computed tomography in patients with bisphosphonate-associated osteonecrosis
Auteurs : Sr Torres [Brésil, États-Unis] ; Csk Chen [États-Unis] ; Bg Leroux [États-Unis] ; Pp Lee [États-Unis] ; Lg Hollender [États-Unis] ; Mm Schubert [États-Unis]Source :
- Dentomaxillofacial Radiology [ 0250-832X ] ; 2011.
Abstract
The aim of this study was to (1) evaluate the fractal dimension (FD) in regions of the mandible on cone beam CT (CBCT) images of patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) and (2) to select the most suitable region of interest (ROI) for further study on detection of bone alterations associated with bisphosphonates.
CBCT images of patients with BP-ONJ were included with matched controls. Values of FD were compared between groups. Selected ROIs were: ROI-1 — below the mandibular foramen; ROI-2 — above the mandibular foramen; ROI-3 — anterior to the mental foramen; ROI-4 — above the mandibular canal. The area of bone exposure was included as ROI-5. The results were analysed using generalized estimating equations and conditional logistic regression.
There were 36 patients (67% female) with a mean age of 60.7 years. The mean FDs were: ROI-1 — 1.678 for controls and 1.673 for patients (
In this preliminary study, BP-ONJ patients had higher FD values than controls at regions close to the alveolar process. The results suggest that FD is a promising tool for detection of bone alterations associated with BP-ONJ.
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DOI: 10.1259/dmfr/14636637
PubMed: 22065799
PubMed Central: 3528156
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<series><title level="j">Dentomaxillofacial Radiology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>The aim of this study was to (1) evaluate the fractal dimension (FD) in regions of the mandible on cone beam CT (CBCT) images of patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) and (2) to select the most suitable region of interest (ROI) for further study on detection of bone alterations associated with bisphosphonates.</p>
</sec>
<sec><title>Methods</title>
<p>CBCT images of patients with BP-ONJ were included with matched controls. Values of FD were compared between groups. Selected ROIs were: ROI-1 — below the mandibular foramen; ROI-2 — above the mandibular foramen; ROI-3 — anterior to the mental foramen; ROI-4 — above the mandibular canal. The area of bone exposure was included as ROI-5. The results were analysed using generalized estimating equations and conditional logistic regression.</p>
</sec>
<sec><title>Results</title>
<p>There were 36 patients (67% female) with a mean age of 60.7 years. The mean FDs were: ROI-1 — 1.678 for controls and 1.673 for patients (<italic>P</italic>
= 0.81); ROI-2 — 1.657 for controls and 1.653 for patients (<italic>P</italic>
= 0.78); ROI-3 — 1.661 for controls and 1.684 for patients (<italic>P</italic>
= 0.17); and ROI-4 — 1.670 for controls and 1.698 for patients (<italic>P</italic>
= 0.03). The value of the FD in the area of exposed bone was the highest (1.729). The odds of being a BP-ONJ patient <italic>vs</italic>
being a control was six times as high for individuals with a higher FD score at ROI-4, although the confidence interval was quite wide owing to the small sample size.</p>
</sec>
<sec><title>Conclusion</title>
<p>In this preliminary study, BP-ONJ patients had higher FD values than controls at regions close to the alveolar process. The results suggest that FD is a promising tool for detection of bone alterations associated with BP-ONJ.</p>
</sec>
</div>
</front>
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