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Periodontal disease as a risk marker in coronary heart disease and chronic kidney disease

Identifieur interne : 003199 ( Ncbi/Curation ); précédent : 003198; suivant : 003200

Periodontal disease as a risk marker in coronary heart disease and chronic kidney disease

Auteurs : Monica A. Fisher [États-Unis] ; Wenche S. Borgnakke [États-Unis] ; George W. Taylor [États-Unis]

Source :

RBID : PMC:3084591

Abstract

Purpose of review

Over half a million Americans die each year from coronary heart disease (CHD), 26 million suffer from chronic kidney disease (CKD), and a large proportion have periodontal disease (PD), a chronic infection of the tissues surrounding teeth. Chronic inflammation contributes to CHD and CKD occurrence and progression, and PD contributes to the cumulated chronic systemic inflammatory burden. This review examines recent evidence regarding the role of PD in CHD and CKD.

Recent findings

Periodontal pathogens cause both local infection and bacteremia, eliciting local and systemic inflammatory responses. PD is associated with the systemic inflammatory reactant CRP, a major risk factor for both CHD and CKD. Non-surgical PD treatment is shown to improve periodontal health, endothelial function and levels of CRP and other inflammatory markers. Evidence for the association of PD with CKD consists of a small body of literature represented mainly by cross-sectional studies. No definitive randomized-controlled trials exist with either CHD or CKD as primary endpoints.

Summary

Recent evidence links PD with CHD and CKD. Adding oral health self-care and referral for professional periodontal assessment and therapy to the repertoire of medical care recommendations is prudent to improve patients’ oral health and possibly reduce CHD and CKD risk.


Url:
DOI: 10.1097/MNH.0b013e32833eda38
PubMed: 20948377
PubMed Central: 3084591

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PMC:3084591

Le document en format XML

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