The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer
Identifieur interne : 001B82 ( Ncbi/Curation ); précédent : 001B81; suivant : 001B83The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer
Auteurs : Pouran Famili ; Jane A. Cauley ; Susan L. GreenspanSource :
- The Journal of urology [ 0022-5347 ] ; 2007.
Abstract
We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss.
A total of 81 men with a mean age of 68.5 years who had prostate cancer were consecutively recruited among 325 enrolled in an academic osteoporosis study. Of these men 68 were eligible to participate in the research. The prevalence of periodontal disease in 41 men with prostate cancer undergoing androgen deprivation for a mean of 1.5 years was compared to that in 27 with prostate cancer not undergoing androgen deprivation, who served as controls. The prevalence of periodontal disease was examined in relation to bone mineral density in men with prostate cancer with and without androgen deprivation therapy. A periodontist (PF) blinded to androgen deprivation status recorded probing depth, clinical attachment level, bleeding, plaque scores, gingival recession, missing teeth and calculus. Logistic regression models were used to test the association between androgen deprivation therapy and periodontal disease. Linear regression models were used to assess the association between periodontal disease and bone mineral density in the 2 groups with prostate cancer (treated/untreated). We adjusted for variables known to influence periodontal disease, including patient age, race, smoking and periodontal disease history.
The prevalence of periodontal disease was 80.5% in men on androgen deprivation therapy compared with 3.7% in those not on androgen deprivation therapy (OR 3.33, 95% CI 1.07–10.35). Men on androgen deprivation therapy had significantly greater probing depth and higher plaque scores (p <0.001 and <0.09, respectively). A total of 81 men (76.9%) completed bone mineral density examinations. There was no relationship between bone mineral density and periodontal disease.
Men with prostate cancer undergoing androgen deprivation therapy were more likely to have periodontal disease than men not on androgen deprivation therapy. If confirmed in larger studies, this observation could have important public health implications, given the increasing use of androgen deprivation therapy to treat prostate cancer.
Url:
DOI: 10.1016/j.juro.2006.10.067
PubMed: 17296376
PubMed Central: 1934505
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002603
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002603
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002673
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001B82
Links to Exploration step
PMC:1934505Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer</title><author><name sortKey="Famili, Pouran" sort="Famili, Pouran" uniqKey="Famili P" first="Pouran" last="Famili">Pouran Famili</name></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17296376</idno><idno type="pmc">1934505</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934505</idno><idno type="RBID">PMC:1934505</idno><idno type="doi">10.1016/j.juro.2006.10.067</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002603</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002603</idno><idno type="wicri:Area/Pmc/Curation">002603</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002603</idno><idno type="wicri:Area/Pmc/Checkpoint">002673</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002673</idno><idno type="wicri:Area/Ncbi/Merge">001B82</idno><idno type="wicri:Area/Ncbi/Curation">001B82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer</title><author><name sortKey="Famili, Pouran" sort="Famili, Pouran" uniqKey="Famili P" first="Pouran" last="Famili">Pouran Famili</name></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name></author></analytic><series><title level="j">The Journal of urology</title><idno type="ISSN">0022-5347</idno><idno type="eISSN">1527-3792</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">We tested the hypothesis that men undergoing androgen deprivation therapy as treatment for prostate cancer are at greater risk for periodontitis and tooth loss.</p></sec><sec sec-type="materials|methods" id="S2"><title>Materials and Methods</title><p id="P2">A total of 81 men with a mean age of 68.5 years who had prostate cancer were consecutively recruited among 325 enrolled in an academic osteoporosis study. Of these men 68 were eligible to participate in the research. The prevalence of periodontal disease in 41 men with prostate cancer undergoing androgen deprivation for a mean of 1.5 years was compared to that in 27 with prostate cancer not undergoing androgen deprivation, who served as controls. The prevalence of periodontal disease was examined in relation to bone mineral density in men with prostate cancer with and without androgen deprivation therapy. A periodontist (PF) blinded to androgen deprivation status recorded probing depth, clinical attachment level, bleeding, plaque scores, gingival recession, missing teeth and calculus. Logistic regression models were used to test the association between androgen deprivation therapy and periodontal disease. Linear regression models were used to assess the association between periodontal disease and bone mineral density in the 2 groups with prostate cancer (treated/untreated). We adjusted for variables known to influence periodontal disease, including patient age, race, smoking and periodontal disease history.</p></sec><sec id="S3"><title>Results</title><p id="P3">The prevalence of periodontal disease was 80.5% in men on androgen deprivation therapy compared with 3.7% in those not on androgen deprivation therapy (OR 3.33, 95% CI 1.07–10.35). Men on androgen deprivation therapy had significantly greater probing depth and higher plaque scores (p <0.001 and <0.09, respectively). A total of 81 men (76.9%) completed bone mineral density examinations. There was no relationship between bone mineral density and periodontal disease.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Men with prostate cancer undergoing androgen deprivation therapy were more likely to have periodontal disease than men not on androgen deprivation therapy. If confirmed in larger studies, this observation could have important public health implications, given the increasing use of androgen deprivation therapy to treat prostate cancer.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001B82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:1934505
|texte= The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:17296376" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |