Immunoconglutinins and C3 in human saliva.
Identifieur interne : 000A49 ( Ncbi/Curation ); précédent : 000A48; suivant : 000A50Immunoconglutinins and C3 in human saliva.
Auteurs : B D Williams ; S J Challacombe ; J M Slaney ; P J Lachmann ; T. LehnerSource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1975.
Abstract
High titres of immunoconglutinin activity (antibody to bound complement components) have been found in the parotid, sublingual and submandibular saliva of most healthy subjects. The immunoconglutinin (IK) titre in mixed saliva was substantially lower than in the other samples of saliva. C3 was detectable in only three of 164 samples of parotid, submandibular and sublingual saliva but was present in forty-seven of 117 mixed saliva samples. It is suggested that crevicular fluid is the major source of C3 in mixed saliva. A negative correlation was found in mixed saliva between the C3 concentration and the IK titre, and this suggested that C3 was the inhibitor of IK in mixed saliva. Binding of C3 to IK has been demonstrated in mixed saliva by using highly purified salivary IK and C3. Purified C3, C3i, C3c and C3d inhibited the activity of purified IK. It is suggested that salivary IK represents the secretion of a B-lymphocyte population which has evaded the mechanism responsible for inducing B-cell tolerance to autologous serum proteins. The reason for its persistence in the salivary glands, however, is not known at present.
Url:
PubMed: 1239346
PubMed Central: 1538149
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001503
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001503
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002A77
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000A49
Links to Exploration step
PMC:1538149Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunoconglutinins and C3 in human saliva.</title>
<author><name sortKey="Williams, B D" sort="Williams, B D" uniqKey="Williams B" first="B D" last="Williams">B D Williams</name>
</author>
<author><name sortKey="Challacombe, S J" sort="Challacombe, S J" uniqKey="Challacombe S" first="S J" last="Challacombe">S J Challacombe</name>
</author>
<author><name sortKey="Slaney, J M" sort="Slaney, J M" uniqKey="Slaney J" first="J M" last="Slaney">J M Slaney</name>
</author>
<author><name sortKey="Lachmann, P J" sort="Lachmann, P J" uniqKey="Lachmann P" first="P J" last="Lachmann">P J Lachmann</name>
</author>
<author><name sortKey="Lehner, T" sort="Lehner, T" uniqKey="Lehner T" first="T" last="Lehner">T. Lehner</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">1239346</idno>
<idno type="pmc">1538149</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538149</idno>
<idno type="RBID">PMC:1538149</idno>
<date when="1975">1975</date>
<idno type="wicri:Area/Pmc/Corpus">001503</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001503</idno>
<idno type="wicri:Area/Pmc/Curation">001503</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001503</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002A77</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002A77</idno>
<idno type="wicri:Area/Ncbi/Merge">000A49</idno>
<idno type="wicri:Area/Ncbi/Curation">000A49</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunoconglutinins and C3 in human saliva.</title>
<author><name sortKey="Williams, B D" sort="Williams, B D" uniqKey="Williams B" first="B D" last="Williams">B D Williams</name>
</author>
<author><name sortKey="Challacombe, S J" sort="Challacombe, S J" uniqKey="Challacombe S" first="S J" last="Challacombe">S J Challacombe</name>
</author>
<author><name sortKey="Slaney, J M" sort="Slaney, J M" uniqKey="Slaney J" first="J M" last="Slaney">J M Slaney</name>
</author>
<author><name sortKey="Lachmann, P J" sort="Lachmann, P J" uniqKey="Lachmann P" first="P J" last="Lachmann">P J Lachmann</name>
</author>
<author><name sortKey="Lehner, T" sort="Lehner, T" uniqKey="Lehner T" first="T" last="Lehner">T. Lehner</name>
</author>
</analytic>
<series><title level="j">Clinical and Experimental Immunology</title>
<idno type="ISSN">0009-9104</idno>
<idno type="eISSN">1365-2249</idno>
<imprint><date when="1975">1975</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>High titres of immunoconglutinin activity (antibody to bound complement components) have been found in the parotid, sublingual and submandibular saliva of most healthy subjects. The immunoconglutinin (IK) titre in mixed saliva was substantially lower than in the other samples of saliva. C3 was detectable in only three of 164 samples of parotid, submandibular and sublingual saliva but was present in forty-seven of 117 mixed saliva samples. It is suggested that crevicular fluid is the major source of C3 in mixed saliva. A negative correlation was found in mixed saliva between the C3 concentration and the IK titre, and this suggested that C3 was the inhibitor of IK in mixed saliva. Binding of C3 to IK has been demonstrated in mixed saliva by using highly purified salivary IK and C3. Purified C3, C3i, C3c and C3d inhibited the activity of purified IK. It is suggested that salivary IK represents the secretion of a B-lymphocyte population which has evaded the mechanism responsible for inducing B-cell tolerance to autologous serum proteins. The reason for its persistence in the salivary glands, however, is not known at present.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A49 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000A49 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:1538149 |texte= Immunoconglutinins and C3 in human saliva. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:1239346" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
This area was generated with Dilib version V0.6.32. |