Biofilm Formation by the Fungal Pathogen Candida albicans: Development, Architecture, and Drug Resistance
Identifieur interne : 000669 ( Ncbi/Curation ); précédent : 000668; suivant : 000670Biofilm Formation by the Fungal Pathogen Candida albicans: Development, Architecture, and Drug Resistance
Auteurs : Jyotsna Chandra ; Duncan M. Kuhn ; Pranab K. Mukherjee ; Lois L. Hoyer ; Thomas Mccormick ; Mahmoud A. GhannoumSource :
- Journal of Bacteriology [ 0021-9193 ] ; 2001.
Abstract
Biofilms are a protected niche for microorganisms, where they are safe from antibiotic treatment and can create a source of persistent infection. Using two clinically relevant
Url:
DOI: 10.1128/JB.183.18.5385-5394.2001
PubMed: 11514524
PubMed Central: 95423
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PMC:95423Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biofilm Formation by the Fungal Pathogen <italic>Candida albicans</italic>
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<series><title level="j">Journal of Bacteriology</title>
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<front><div type="abstract" xml:lang="en"><p>Biofilms are a protected niche for microorganisms, where they are safe from antibiotic treatment and can create a source of persistent infection. Using two clinically relevant <italic>Candida albicans</italic>
biofilm models formed on bioprosthetic materials, we demonstrated that biofilm formation proceeds through three distinct developmental phases. These growth phases transform adherent blastospores to well-defined cellular communities encased in a polysaccharide matrix. Fluorescence and confocal scanning laser microscopy revealed that <italic>C. albicans</italic>
biofilms have a highly heterogeneous architecture composed of cellular and noncellular elements. In both models, antifungal resistance of biofilm-grown cells increased in conjunction with biofilm formation. The expression of agglutinin-like (<italic>ALS</italic>
) genes, which encode a family of proteins implicated in adhesion to host surfaces, was differentially regulated between planktonic and biofilm-grown cells. The ability of <italic>C. albicans</italic>
to form biofilms contrasts sharply with that of <italic>Saccharomyces cerevisiae</italic>
, which adhered to bioprosthetic surfaces but failed to form a mature biofilm. The studies described here form the basis for investigations into the molecular mechanisms of <italic>Candida</italic>
biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections.</p>
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