Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation
Identifieur interne : 007055 ( Ncbi/Checkpoint ); précédent : 007054; suivant : 007056Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation
Auteurs : Chengrong Kang ; Limin Wei ; Bin Song ; Liangjiao Chen [République populaire de Chine] ; Jia Liu ; Bin Deng [République populaire de Chine] ; Xuan Pan ; Longquan ShaoSource :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2017.
Abstract
Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, and they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) that were deposited on the surface of a porous Ta implant are inevitably released and come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior and implant stabilization. However, the interaction of Ta-NPs with osteoblasts has not been clearly investigated. This study aimed to investigate the effect of Ta-NPs on cell proliferation and their underlying mechanism. The Cell Counting Kit-8 (CCK-8) assay was used to measure the cell viability of MC3T3-E1 mouse osteoblasts and showed that Ta-NP treatment could increase cell viability. Then, confocal microscopy, Western blotting, and transmission electron microscopy were used to confirm the autophagy induced by Ta-NPs, and evidence of autophagy induction was observed as positive LC3 puncta, high-LC3-II expression, and autophagic vesicle ultrastructures. The CCK-8 assay revealed that the cell viability was further increased and decreased by the application of an autophagy inducer and inhibitor, respectively. In addition, pre-treatment with autophagy inhibitor 3-methyladenine (3-MA) inhibited the Ta-NP-induced autophagy. These results indicate that the Ta-NPs can promote cell proliferation, that an autophagy inducer can further strengthen this effect and that an autophagy inhibitor can weaken this effect. In conclusion, autophagy was involved in Ta-NP-induced cell proliferation and had a promoting effect.
Url:
DOI: 10.2147/IJN.S136281
PubMed: 28652735
PubMed Central: 5473603
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation</title><author><name sortKey="Kang, Chengrong" sort="Kang, Chengrong" uniqKey="Kang C" first="Chengrong" last="Kang">Chengrong Kang</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation><affiliation><nlm:aff id="af2-ijn-12-4323">Department of Stomatology, The First Affiliated Hospital of Guangdong Pharmaceutical University</nlm:aff><wicri:noCountry code="subfield">The First Affiliated Hospital of Guangdong Pharmaceutical University</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Limin" sort="Wei, Limin" uniqKey="Wei L" first="Limin" last="Wei">Limin Wei</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Song, Bin" sort="Song, Bin" uniqKey="Song B" first="Bin" last="Song">Bin Song</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Liangjiao" sort="Chen, Liangjiao" uniqKey="Chen L" first="Liangjiao" last="Chen">Liangjiao Chen</name><affiliation wicri:level="3"><nlm:aff id="af3-ijn-12-4323">Department of Orthodontics, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Department of Orthodontics, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University</wicri:orgArea></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Deng, Bin" sort="Deng, Bin" uniqKey="Deng B" first="Bin" last="Deng">Bin Deng</name><affiliation wicri:level="3"><nlm:aff id="af4-ijn-12-4323">Department of Stomatology, The General Hospital of People’s Liberation Army, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, The General Hospital of People’s Liberation 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Chengrong" sort="Kang, Chengrong" uniqKey="Kang C" first="Chengrong" last="Kang">Chengrong Kang</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation><affiliation><nlm:aff id="af2-ijn-12-4323">Department of Stomatology, The First Affiliated Hospital of Guangdong Pharmaceutical University</nlm:aff><wicri:noCountry code="subfield">The First Affiliated Hospital of Guangdong Pharmaceutical University</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Limin" sort="Wei, Limin" uniqKey="Wei L" first="Limin" last="Wei">Limin Wei</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Song, Bin" sort="Song, Bin" uniqKey="Song B" first="Bin" last="Song">Bin Song</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Liangjiao" sort="Chen, Liangjiao" uniqKey="Chen L" first="Liangjiao" last="Chen">Liangjiao Chen</name><affiliation wicri:level="3"><nlm:aff id="af3-ijn-12-4323">Department of Orthodontics, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><wicri:orgArea>Department of Orthodontics, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University</wicri:orgArea></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author><author><name sortKey="Deng, Bin" sort="Deng, Bin" uniqKey="Deng B" first="Bin" last="Deng">Bin Deng</name><affiliation wicri:level="3"><nlm:aff id="af4-ijn-12-4323">Department of Stomatology, The General Hospital of People’s Liberation Army, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, The General Hospital of People’s Liberation Army, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Pan, Xuan" sort="Pan, Xuan" uniqKey="Pan X" first="Xuan" last="Pan">Xuan Pan</name><affiliation><nlm:aff id="af2-ijn-12-4323">Department of Stomatology, The First Affiliated Hospital of Guangdong Pharmaceutical University</nlm:aff><wicri:noCountry code="subfield">The First Affiliated Hospital of Guangdong Pharmaceutical University</wicri:noCountry></affiliation></author><author><name sortKey="Shao, Longquan" sort="Shao, Longquan" uniqKey="Shao L" first="Longquan" last="Shao">Longquan Shao</name><affiliation><nlm:aff id="af1-ijn-12-4323">Department of Stomatology, Nanfang Hospital, Southern Medical University</nlm:aff><wicri:noCountry code="subfield">Southern Medical University</wicri:noCountry></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, and they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) that were deposited on the surface of a porous Ta implant are inevitably released and come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior and implant stabilization. However, the interaction of Ta-NPs with osteoblasts has not been clearly investigated. This study aimed to investigate the effect of Ta-NPs on cell proliferation and their underlying mechanism. The Cell Counting Kit-8 (CCK-8) assay was used to measure the cell viability of MC3T3-E1 mouse osteoblasts and showed that Ta-NP treatment could increase cell viability. Then, confocal microscopy, Western blotting, and transmission electron microscopy were used to confirm the autophagy induced by Ta-NPs, and evidence of autophagy induction was observed as positive LC3 puncta, high-LC3-II expression, and autophagic vesicle ultrastructures. The CCK-8 assay revealed that the cell viability was further increased and decreased by the application of an autophagy inducer and inhibitor, respectively. In addition, pre-treatment with autophagy inhibitor 3-methyladenine (3-MA) inhibited the Ta-NP-induced autophagy. These results indicate that the Ta-NPs can promote cell proliferation, that an autophagy inducer can further strengthen this effect and that an autophagy inhibitor can weaken this effect. In conclusion, autophagy was involved in Ta-NP-induced cell proliferation and had a promoting effect.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P Zhang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balla, Vk" uniqKey="Balla V">VK Balla</name></author><author><name sortKey="Banerjee, S" uniqKey="Banerjee S">S Banerjee</name></author><author><name sortKey="Bose, S" uniqKey="Bose S">S Bose</name></author><author><name sortKey="Bandyopadhyay, A" uniqKey="Bandyopadhyay A">A Bandyopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balla, Vk" uniqKey="Balla 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Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Kang, Chengrong" sort="Kang, Chengrong" uniqKey="Kang C" first="Chengrong" last="Kang">Chengrong Kang</name><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><name sortKey="Pan, Xuan" sort="Pan, Xuan" uniqKey="Pan X" first="Xuan" last="Pan">Xuan Pan</name><name sortKey="Shao, Longquan" sort="Shao, Longquan" uniqKey="Shao L" first="Longquan" last="Shao">Longquan Shao</name><name sortKey="Song, Bin" sort="Song, Bin" uniqKey="Song B" first="Bin" last="Song">Bin Song</name><name sortKey="Wei, Limin" sort="Wei, Limin" uniqKey="Wei L" first="Limin" last="Wei">Limin Wei</name></noCountry><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Chen, Liangjiao" sort="Chen, Liangjiao" uniqKey="Chen L" first="Liangjiao" last="Chen">Liangjiao Chen</name></region><name sortKey="Deng, Bin" sort="Deng, Bin" uniqKey="Deng B" first="Bin" last="Deng">Bin Deng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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