Local anesthesia with epinephrine is safe and effective for oral surgery in patients with type 2 diabetes mellitus and coronary disease: a prospective randomized study
Identifieur interne : 005B90 ( Ncbi/Checkpoint ); précédent : 005B89; suivant : 005B91Local anesthesia with epinephrine is safe and effective for oral surgery in patients with type 2 diabetes mellitus and coronary disease: a prospective randomized study
Auteurs : Marcela Alves Dos Santos-Paul [Brésil] ; Itamara Lucia Itagiba Neves [Brésil] ; Ricardo Sim Es Neves [Brésil] ; José Antonio Franchini Ramires [Brésil]Source :
- Clinics [ 1807-5932 ] ; 2015.
Abstract
To investigate the variations in blood glucose levels, hemodynamic effects and patient anxiety scores during tooth extraction in patients with type 2 diabetes mellitus T2DM and coronary disease under local anesthesia with 2% lidocaine with or without epinephrine.
This is a prospective randomized study of 70 patients with T2DM with coronary disease who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood glucose levels were continuously monitored for 24 hours using the MiniMed Continuous Glucose Monitoring System. Patients were randomized into two groups: 35 patients received 5.4 mL of 2% lidocaine, and 35 patients received 5.4 mL of 2% lidocaine with 1:100,000 epinephrine. Hemodynamic parameters (blood pressure and heart rate) and anxiety levels were also evaluated.
There was no difference in blood glucose levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood glucose levels over time. The groups showed no significant differences in hemodynamic and anxiety status parameters.
The administration of 5.4 mL of 2% lidocaine with epinephrine neither caused hyperglycemia nor had any significant impact on hemodynamic or anxiety parameters. However, lower blood glucose levels were observed. This is the first report using continuous blood glucose monitoring to show the benefits and lack of side effects of local anesthesia with epinephrine in patients with type 2 diabetes mellitus and coronary disease.
Url:
DOI: 10.6061/clinics/2015(03)06
PubMed: 26017649
PubMed Central: 4449474
Affiliations:
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id="af1-cln_70p185">Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Neves, Itamara Lucia Itagiba" sort="Neves, Itamara Lucia Itagiba" uniqKey="Neves I" first="Itamara Lucia Itagiba" last="Neves">Itamara Lucia Itagiba Neves</name><affiliation wicri:level="4"><nlm:aff id="af1-cln_70p185">Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Neves, Ricardo Sim Es" sort="Neves, Ricardo Sim Es" uniqKey="Neves R" first="Ricardo Sim Es" last="Neves">Ricardo Sim Es Neves</name><affiliation wicri:level="4"><nlm:aff id="af1-cln_70p185">Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Dental Unit, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Ramires, Jose Antonio Franchini" sort="Ramires, Jose Antonio Franchini" uniqKey="Ramires J" first="José Antonio Franchini" last="Ramires">José Antonio Franchini Ramires</name><affiliation wicri:level="4"><nlm:aff id="af2-cln_70p185">Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Cardiology, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Cardiology, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j">Clinics</title><idno type="ISSN">1807-5932</idno><idno type="eISSN">1980-5322</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>OBJECTIVE:</title><p>To investigate the variations in blood glucose levels, hemodynamic effects and patient anxiety scores during tooth extraction in patients with type 2 diabetes mellitus T2DM and coronary disease under local anesthesia with 2% lidocaine with or without epinephrine.</p></sec><sec><title>STUDY DESIGN:</title><p>This is a prospective randomized study of 70 patients with T2DM with coronary disease who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood glucose levels were continuously monitored for 24 hours using the MiniMed Continuous Glucose Monitoring System. Patients were randomized into two groups: 35 patients received 5.4 mL of 2% lidocaine, and 35 patients received 5.4 mL of 2% lidocaine with 1:100,000 epinephrine. Hemodynamic parameters (blood pressure and heart rate) and anxiety levels were also evaluated.</p></sec><sec><title>RESULTS:</title><p>There was no difference in blood glucose levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood glucose levels over time. The groups showed no significant differences in hemodynamic and anxiety status parameters.</p></sec><sec><title>CONCLUSION:</title><p>The administration of 5.4 mL of 2% lidocaine with epinephrine neither caused hyperglycemia nor had any significant impact on hemodynamic or anxiety parameters. However, lower blood glucose levels were observed. This is the first report using continuous blood glucose monitoring to show the benefits and lack of side effects of local anesthesia with epinephrine in patients with type 2 diabetes mellitus and coronary disease.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shlossman, M" uniqKey="Shlossman M">M Shlossman</name></author><author><name sortKey="Knowler, Wc" uniqKey="Knowler W">WC Knowler</name></author><author><name sortKey="Pettitt, Dj" uniqKey="Pettitt D">DJ Pettitt</name></author><author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Preshaw, Pm" uniqKey="Preshaw P">PM Preshaw</name></author><author><name sortKey="Alba, Al" uniqKey="Alba A">AL Alba</name></author><author><name sortKey="Herrera, D" uniqKey="Herrera D">D Herrera</name></author><author><name sortKey="Jepsen, S" uniqKey="Jepsen S">S Jepsen</name></author><author><name sortKey="Konstantinidis, A" uniqKey="Konstantinidis A">A Konstantinidis</name></author><author><name sortKey="Makrilakis, K" uniqKey="Makrilakis K">K Makrilakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papapanou, Pn" uniqKey="Papapanou P">PN Papapanou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalla, Rv" uniqKey="Lalla R">RV Lalla</name></author><author><name sortKey="D Ambrosio, Ja" uniqKey="D Ambrosio J">JA D'Ambrosio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albandar, Jm" uniqKey="Albandar J">JM Albandar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barcellos, If" uniqKey="Barcellos I">IF Barcellos</name></author><author><name sortKey="Halfon, Vlc" uniqKey="Halfon V">VLC Halfon</name></author><author><name sortKey="Oliveira, Lf" uniqKey="Oliveira L">LF Oliveira</name></author><author><name sortKey="Barcellos Filho, I" uniqKey="Barcellos Filho I">I Barcellos Filho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galili, D" uniqKey="Galili D">D Galili</name></author><author><name sortKey="Findler, M" uniqKey="Findler M">M Findler</name></author><author><name sortKey="Garfunkel, Aa" uniqKey="Garfunkel A">AA Garfunkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rhodus, Nl" uniqKey="Rhodus N">NL Rhodus</name></author><author><name sortKey="Vibeto, Bm" uniqKey="Vibeto B">BM Vibeto</name></author><author><name sortKey="Hamamoto, Dt" uniqKey="Hamamoto D">DT Hamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mariano, Rc" uniqKey="Mariano R">RC Mariano</name></author><author><name sortKey="Santana, Si" uniqKey="Santana S">SI Santana</name></author><author><name sortKey="Coura, Gs" uniqKey="Coura G">GS Coura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meral, G" uniqKey="Meral G">G Meral</name></author><author><name sortKey="Tasar, F" uniqKey="Tasar F">F Tasar</name></author><author><name sortKey="Sayin, F" uniqKey="Sayin F">F Sayin</name></author><author><name sortKey="Saysel, M" uniqKey="Saysel M">M Saysel</name></author><author><name sortKey="Kir, S" uniqKey="Kir S">S Kir</name></author><author><name sortKey="Karabulut, E" uniqKey="Karabulut E">E Karabulut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoll Kohler, E" uniqKey="Knoll Kohler E">E Knoll-Kohler</name></author><author><name sortKey="Fortsch, G" uniqKey="Fortsch G">G Fortsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoll Kohler, E" uniqKey="Knoll Kohler E">E Knoll-Kohler</name></author><author><name sortKey="Knoller, M" uniqKey="Knoller M">M Knoller</name></author><author><name sortKey="Brandt, K" uniqKey="Brandt K">K Brandt</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niwa, H" uniqKey="Niwa H">H Niwa</name></author><author><name sortKey="Hirota, Y" uniqKey="Hirota Y">Y Hirota</name></author><author><name sortKey="Sibutani, T" uniqKey="Sibutani T">T Sibutani</name></author><author><name sortKey="Idohji, Y" uniqKey="Idohji Y">Y Idohji</name></author><author><name sortKey="Hori, T" uniqKey="Hori T">T Hori</name></author><author><name sortKey="Sugiyama, K" uniqKey="Sugiyama K">K Sugiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cioffi, Ga" uniqKey="Cioffi G">GA Cioffi</name></author><author><name sortKey="Chernow, B" uniqKey="Chernow B">B Chernow</name></author><author><name sortKey="Glahn, Rp" uniqKey="Glahn R">RP Glahn</name></author><author><name sortKey="Terezhalmy, Gt" uniqKey="Terezhalmy G">GT Terezhalmy</name></author><author><name sortKey="Lake, Cr" uniqKey="Lake C">CR Lake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Fu" uniqKey="Meyer F">FU Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, Ds" uniqKey="Goldstein D">DS Goldstein</name></author><author><name sortKey="Dionne, R" uniqKey="Dionne R">R Dionne</name></author><author><name sortKey="Sweet, J" uniqKey="Sweet J">J Sweet</name></author><author><name sortKey="Gracely, R" uniqKey="Gracely R">R Gracely</name></author><author><name sortKey="Brewer, Hb" uniqKey="Brewer H">HB Brewer</name></author><author><name sortKey="Gregg, R" uniqKey="Gregg R">R Gregg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tolas, Ag" uniqKey="Tolas A">AG Tolas</name></author><author><name sortKey="Pflug, Ae" uniqKey="Pflug A">AE Pflug</name></author><author><name sortKey="Halter, Jb" uniqKey="Halter J">JB Halter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chernow, B" uniqKey="Chernow B">B Chernow</name></author><author><name sortKey="Balestrieri, F" uniqKey="Balestrieri F">F Balestrieri</name></author><author><name sortKey="Ferguson, Cd" uniqKey="Ferguson C">CD Ferguson</name></author><author><name sortKey="Terezhalmy, Gt" uniqKey="Terezhalmy G">GT Terezhalmy</name></author><author><name sortKey="Fletcher, Jr" uniqKey="Fletcher J">JR Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dionne, Ra" uniqKey="Dionne R">RA Dionne</name></author><author><name sortKey="Goldstein, Ds" uniqKey="Goldstein D">DS Goldstein</name></author><author><name sortKey="Wirdzek, Pr" uniqKey="Wirdzek P">PR Wirdzek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vernillo, At" uniqKey="Vernillo A">AT Vernillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orso, Va" uniqKey="Orso V">VA Orso</name></author><author><name sortKey="Pagnoncelli, Rm" uniqKey="Pagnoncelli R">RM Pagnoncelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mistro, Fz" uniqKey="Mistro F">FZ Mistro</name></author><author><name sortKey="Kignel, S" uniqKey="Kignel S">S Kignel</name></author><author><name sortKey="Cardoso, Ds" uniqKey="Cardoso D">DS Cardoso</name></author><author><name sortKey="Morais, Es" uniqKey="Morais E">ES Morais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haas, Da" uniqKey="Haas D">DA Haas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levin, Ja" uniqKey="Levin J">JA Levin</name></author><author><name sortKey="Muzyka, Bc" uniqKey="Muzyka B">BC Muzyka</name></author><author><name sortKey="Glick, M" uniqKey="Glick M">M Glick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malamed, Sf" uniqKey="Malamed S">SF Malamed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchanan, H" uniqKey="Buchanan H">H Buchanan</name></author><author><name sortKey="Niven, N" uniqKey="Niven N">N Niven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dajani, As" uniqKey="Dajani A">AS Dajani</name></author><author><name sortKey="Taubert, Ka" uniqKey="Taubert K">KA Taubert</name></author><author><name sortKey="Wilson, W" uniqKey="Wilson W">W Wilson</name></author><author><name sortKey="Bolger, Af" uniqKey="Bolger A">AF Bolger</name></author><author><name sortKey="Bayer, A" uniqKey="Bayer A">A Bayer</name></author><author><name sortKey="Ferrieri, P" uniqKey="Ferrieri P">P Ferrieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Timm, Nh" uniqKey="Timm N">NH Timm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bortoluzzi, Mc" uniqKey="Bortoluzzi M">MC Bortoluzzi</name></author><author><name sortKey="Manfro, R" uniqKey="Manfro R">R Manfro</name></author><author><name sortKey="Nardi, A" uniqKey="Nardi A">A Nardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tily, Fe" uniqKey="Tily F">FE Tily</name></author><author><name sortKey="Thomas, S" uniqKey="Thomas S">S Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaira, Vr" uniqKey="Schaira V">VR Schaira</name></author><author><name sortKey="Ranali, J" uniqKey="Ranali J">J Ranali</name></author><author><name sortKey="Saad, Mj" uniqKey="Saad M">MJ Saad</name></author><author><name sortKey="De Oliveira, Pc" uniqKey="De Oliveira P">PC de Oliveira</name></author><author><name sortKey="Ambrosano, Gm" uniqKey="Ambrosano G">GM Ambrosano</name></author><author><name sortKey="Volpato, Mc" uniqKey="Volpato M">MC Volpato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meechan, Jg" uniqKey="Meechan J">JG Meechan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meechan, Jg" uniqKey="Meechan J">JG Meechan</name></author><author><name sortKey="Welbury, Rr" uniqKey="Welbury R">RR Welbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, Y" uniqKey="Nakamura Y">Y Nakamura</name></author><author><name sortKey="Matsumura, K" uniqKey="Matsumura K">K Matsumura</name></author><author><name sortKey="Miura, K" uniqKey="Miura K">K Miura</name></author><author><name sortKey="Kurokawa, H" uniqKey="Kurokawa H">H Kurokawa</name></author><author><name sortKey="Abe, I" uniqKey="Abe I">I Abe</name></author><author><name sortKey="Takata, Y" uniqKey="Takata Y">Y Takata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalra, P" uniqKey="Kalra P">P Kalra</name></author><author><name sortKey="Rana, As" uniqKey="Rana A">AS Rana</name></author><author><name sortKey="Peravali, Rk" uniqKey="Peravali R">RK Peravali</name></author><author><name sortKey="Gupta, D" uniqKey="Gupta D">D Gupta</name></author><author><name sortKey="Jain, G" uniqKey="Jain G">G Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vernillo, At" uniqKey="Vernillo A">AT Vernillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neves, Rs" uniqKey="Neves R">RS Neves</name></author><author><name sortKey="Neves, Il" uniqKey="Neves I">IL Neves</name></author><author><name sortKey="Giorgi, Dm" uniqKey="Giorgi D">DM Giorgi</name></author><author><name sortKey="Grupi, Cj" uniqKey="Grupi C">CJ Grupi</name></author><author><name sortKey="Cesar, La" uniqKey="Cesar L">LA Cesar</name></author><author><name sortKey="Hueb, W" uniqKey="Hueb W">W Hueb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conrado, Vc" uniqKey="Conrado V">VC Conrado</name></author><author><name sortKey="De Andrade, J" uniqKey="De Andrade J">J de Andrade</name></author><author><name sortKey="De Angelis, Ga" uniqKey="De Angelis G">GA de Angelis</name></author><author><name sortKey="De Andrade, Ac" uniqKey="De Andrade A">AC de Andrade</name></author><author><name sortKey="Timerman, L" uniqKey="Timerman L">L Timerman</name></author><author><name sortKey="Andrade, Mm" uniqKey="Andrade M">MM Andrade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y Takahashi</name></author><author><name sortKey="Nakano, M" uniqKey="Nakano M">M Nakano</name></author><author><name sortKey="Sano, K" uniqKey="Sano K">K Sano</name></author><author><name sortKey="Kanri, T" uniqKey="Kanri T">T Kanri</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Dos Santos Paul, Marcela Alves" sort="Dos Santos Paul, Marcela Alves" uniqKey="Dos Santos Paul M" first="Marcela Alves" last="Dos Santos-Paul">Marcela Alves Dos Santos-Paul</name></region><name sortKey="Neves, Itamara Lucia Itagiba" sort="Neves, Itamara Lucia Itagiba" uniqKey="Neves I" first="Itamara Lucia Itagiba" last="Neves">Itamara Lucia Itagiba Neves</name><name sortKey="Neves, Ricardo Sim Es" sort="Neves, Ricardo Sim Es" uniqKey="Neves R" first="Ricardo Sim Es" last="Neves">Ricardo Sim Es Neves</name><name sortKey="Ramires, Jose Antonio Franchini" sort="Ramires, Jose Antonio Franchini" uniqKey="Ramires J" first="José Antonio Franchini" last="Ramires">José Antonio Franchini Ramires</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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