Paget disease of bone: A classic case report
Identifieur interne : 004965 ( Ncbi/Checkpoint ); précédent : 004964; suivant : 004966Paget disease of bone: A classic case report
Auteurs : Y. Uday Shankar ; Satya Ranjan Misra ; Daniel Alex Vineet ; Pavitra BaskaranSource :
- Contemporary Clinical Dentistry [ 0976-237X ] ; 2013.
Abstract
Paget disease of bone (PDB) is a chronic progressive disease of the bone of uncertain etiology, characterized initially by an increase in bone resorption, followed by a disorganized and excessive formation of bone, leading to pain, fractures, and deformities. It can manifest as a monostotic or polyostotic disease. The prevalence of PDB is common in the Anglo-Saxon population, but relatively rare in India. The disease is often asymptomatic and commonly seen in an aging population. The diagnosis of the disease is mostly based on radiological examination and on biochemical markers of bone turnover. Markedly elevated serum alkaline phosphatase (SAP) is a constant feature while calcium and phosphate levels are typically within normal limits. It is being successfully treated by biphosphonates, a group of anti-resorptive drugs, thereby decreasing the morbidity and mortality associated with the disease. We report a classic case of PDB with craniofacial involvement resulting in Leontiasis Ossea (lion like face), cotton wool appearance of the skull and elevated SAP.
Url:
DOI: 10.4103/0976-237X.114858
PubMed: 24015015
PubMed Central: 3757888
Affiliations:
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Uday Shankar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Misra, Satya Ranjan" sort="Misra, Satya Ranjan" uniqKey="Misra S" first="Satya Ranjan" last="Misra">Satya Ranjan Misra</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India</italic></nlm:aff></affiliation></author><author><name sortKey="Vineet, Daniel Alex" sort="Vineet, Daniel Alex" uniqKey="Vineet D" first="Daniel Alex" last="Vineet">Daniel Alex Vineet</name><affiliation><nlm:aff id="aff3"><italic>Department of Oral Medicine and Radiology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Kerala, India</italic></nlm:aff></affiliation></author><author><name sortKey="Baskaran, Pavitra" sort="Baskaran, Pavitra" uniqKey="Baskaran P" first="Pavitra" last="Baskaran">Pavitra Baskaran</name><affiliation><nlm:aff id="aff4"><italic>Department of Oral Medicine and Radiology, SRM Kattankulanthur Dental College, Kancheepuram, Tamil Nadu, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24015015</idno><idno type="pmc">3757888</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757888</idno><idno type="RBID">PMC:3757888</idno><idno type="doi">10.4103/0976-237X.114858</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001C05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C05</idno><idno type="wicri:Area/Pmc/Curation">001C05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C05</idno><idno type="wicri:Area/Pmc/Checkpoint">001875</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001875</idno><idno type="wicri:Area/Ncbi/Merge">004965</idno><idno type="wicri:Area/Ncbi/Curation">004965</idno><idno type="wicri:Area/Ncbi/Checkpoint">004965</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Paget disease of bone: A classic case report</title><author><name sortKey="Shankar, Y Uday" sort="Shankar, Y Uday" uniqKey="Shankar Y" first="Y. Uday" last="Shankar">Y. Uday Shankar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Misra, Satya Ranjan" sort="Misra, Satya Ranjan" uniqKey="Misra S" first="Satya Ranjan" last="Misra">Satya Ranjan Misra</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India</italic></nlm:aff></affiliation></author><author><name sortKey="Vineet, Daniel Alex" sort="Vineet, Daniel Alex" uniqKey="Vineet D" first="Daniel Alex" last="Vineet">Daniel Alex Vineet</name><affiliation><nlm:aff id="aff3"><italic>Department of Oral Medicine and Radiology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Kerala, India</italic></nlm:aff></affiliation></author><author><name sortKey="Baskaran, Pavitra" sort="Baskaran, Pavitra" uniqKey="Baskaran P" first="Pavitra" last="Baskaran">Pavitra Baskaran</name><affiliation><nlm:aff id="aff4"><italic>Department of Oral Medicine and Radiology, SRM Kattankulanthur Dental College, Kancheepuram, Tamil Nadu, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Contemporary Clinical Dentistry</title><idno type="ISSN">0976-237X</idno><idno type="eISSN">0976-2361</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Paget disease of bone (PDB) is a chronic progressive disease of the bone of uncertain etiology, characterized initially by an increase in bone resorption, followed by a disorganized and excessive formation of bone, leading to pain, fractures, and deformities. It can manifest as a monostotic or polyostotic disease. The prevalence of PDB is common in the Anglo-Saxon population, but relatively rare in India. The disease is often asymptomatic and commonly seen in an aging population. The diagnosis of the disease is mostly based on radiological examination and on biochemical markers of bone turnover. Markedly elevated serum alkaline phosphatase (SAP) is a constant feature while calcium and phosphate levels are typically within normal limits. It is being successfully treated by biphosphonates, a group of anti-resorptive drugs, thereby decreasing the morbidity and mortality associated with the disease. We report a classic case of PDB with craniofacial involvement resulting in Leontiasis Ossea (lion like face), cotton wool appearance of the skull and elevated SAP.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Eversole, R" uniqKey="Eversole R">R Eversole</name></author><author><name sortKey="Su, L" uniqKey="Su L">L Su</name></author><author><name sortKey="Elmofty, S" uniqKey="Elmofty S">S ElMofty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastin, S" uniqKey="Bastin S">S Bastin</name></author><author><name sortKey="Bird, H" uniqKey="Bird H">H Bird</name></author><author><name sortKey="Gamble, G" uniqKey="Gamble G">G Gamble</name></author><author><name sortKey="Cundy, T" uniqKey="Cundy T">T Cundy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bae, Kb" uniqKey="Bae K">KB Bae</name></author><author><name sortKey="Kwon, Jh" uniqKey="Kwon J">JH Kwon</name></author><author><name sortKey="Kim, Yh" uniqKey="Kim Y">YH Kim</name></author><author><name sortKey="Jung, Ty" uniqKey="Jung T">TY Jung</name></author><author><name sortKey="Cho, Jh" uniqKey="Cho J">JH Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karunakaran, K" uniqKey="Karunakaran K">K Karunakaran</name></author><author><name sortKey="Murugesan, P" uniqKey="Murugesan P">P Murugesan</name></author><author><name sortKey="Rajeshwar, G" uniqKey="Rajeshwar G">G Rajeshwar</name></author><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sekar, B" uniqKey="Sekar B">B Sekar</name></author><author><name sortKey="Augustine, D" uniqKey="Augustine D">D Augustine</name></author><author><name sortKey="Murali, S" uniqKey="Murali S">S Murali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theodorou, Dj" uniqKey="Theodorou D">DJ Theodorou</name></author><author><name sortKey="Theodorou, Sj" uniqKey="Theodorou S">SJ Theodorou</name></author><author><name sortKey="Kakitsubata, Y" uniqKey="Kakitsubata Y">Y Kakitsubata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butt, St" uniqKey="Butt S">ST Butt</name></author><author><name sortKey="Fatima, S" uniqKey="Fatima S">S Fatima</name></author><author><name sortKey="Butt, R" uniqKey="Butt R">R Butt</name></author><author><name sortKey="Nasir, W" uniqKey="Nasir W">W Nasir</name></author><author><name sortKey="Jameel, G" uniqKey="Jameel G">G Jameel</name></author><author><name sortKey="Irfan, J" uniqKey="Irfan J">J Irfan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhargava, P" uniqKey="Bhargava P">P Bhargava</name></author><author><name sortKey="Maki, Jh" uniqKey="Maki J">JH Maki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roodman, Gd" uniqKey="Roodman G">GD Roodman</name></author><author><name sortKey="Windle, Jj" uniqKey="Windle J">JJ Windle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michou, L" uniqKey="Michou L">L Michou</name></author><author><name sortKey="Brown, Jp" uniqKey="Brown J">JP Brown</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baskaran, Pavitra" sort="Baskaran, Pavitra" uniqKey="Baskaran P" first="Pavitra" last="Baskaran">Pavitra Baskaran</name><name sortKey="Misra, Satya Ranjan" sort="Misra, Satya Ranjan" uniqKey="Misra S" first="Satya Ranjan" last="Misra">Satya Ranjan Misra</name><name sortKey="Shankar, Y Uday" sort="Shankar, Y Uday" uniqKey="Shankar Y" first="Y. Uday" last="Shankar">Y. Uday Shankar</name><name sortKey="Vineet, Daniel Alex" sort="Vineet, Daniel Alex" uniqKey="Vineet D" first="Daniel Alex" last="Vineet">Daniel Alex Vineet</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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