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PERI-IMPLANT VERSUS PERIODONTAL WOUND HEALING

Identifieur interne : 004755 ( Ncbi/Checkpoint ); précédent : 004754; suivant : 004756

PERI-IMPLANT VERSUS PERIODONTAL WOUND HEALING

Auteurs : Pinar Emecen-Huja ; Tim D. Eubank ; Vladimir Shapiro ; Vedat Yildiz ; Dimitris N. Tatakis ; Binnaz Leblebicioglu

Source :

Journal of clinical periodontology [ 0303-6979 ] ; 2013.

RBID : PMC:3725126

Abstract

Aim

Peri-implant gingival healing following one-stage implant placement was investigated and compared to periodontal healing.

Methods

Healing at surgical sites (implant (I) and adjacent teeth (T+)) was compared to non-operated tooth (T-) in non-smokers receiving one-stage implant. Periodontal Indices (PI, GI) were recorded at surgery and up to 12 weeks postoperatively. Peri-implant (PICF) and gingival crevicular (GCF) fluids were analyzed for cytokines, collagenases and inhibitors. Data was analyzed by linear mixed model regression analysis and repeated measures ANOVA.

Results

40 patients (22 female; 21-74 yrs old) completed the study. Surgical site GI, increased at week 1, decreased significantly during early healing (weeks 1-3; p=0.0003) and continually decreased during late healing (weeks 6-12) for I (p<0.01). PICF volume decreased 3-fold by week 12 (p=0.0003). IL-6, IL-8, MIP-1β, and TIMP-1 levels significantly increased at surgical sites at week one, significantly decreasing thereafter (P<0.016). Week one IL-6, IL-8 and MIP-1β levels were ~3-fold higher, and TIMP-1 levels 63% higher, at I compared to T+ (p=0.001).

Conclusion

Peri-implant gingival healing, as determined by crevicular fluid molecular composition, differs from periodontal healing. The observed differences suggest that peri-implant tissues, compared to periodontal tissues, represent a higher pro-inflammatory state.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725126

DOI: 10.1111/jcpe.12127
PubMed: 23772674
PubMed Central: 3725126

Affiliations:

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PMC:3725126

Le document en format XML

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<affiliation><nlm:aff id="A1"> Division of Periodontology, College of Dentistry, The Ohio State University</nlm:aff>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim</title>
<p id="P3">Peri-implant gingival healing following one-stage implant placement was investigated and compared to periodontal healing.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P4">Healing at surgical sites (implant (I) and adjacent teeth (T+)) was compared to non-operated tooth (T-) in non-smokers receiving one-stage implant. Periodontal Indices (PI, GI) were recorded at surgery and up to 12 weeks postoperatively. Peri-implant (PICF) and gingival crevicular (GCF) fluids were analyzed for cytokines, collagenases and inhibitors. Data was analyzed by linear mixed model regression analysis and repeated measures ANOVA.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P5">40 patients (22 female; 21-74 yrs old) completed the study. Surgical site GI, increased at week 1, decreased significantly during early healing (weeks 1-3; p=0.0003) and continually decreased during late healing (weeks 6-12) for I (p<0.01). PICF volume decreased 3-fold by week 12 (p=0.0003). IL-6, IL-8, MIP-1β, and TIMP-1 levels significantly increased at surgical sites at week one, significantly decreasing thereafter (P<0.016). Week one IL-6, IL-8 and MIP-1β levels were ~3-fold higher, and TIMP-1 levels 63% higher, at I compared to T+ (p=0.001).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P6">Peri-implant gingival healing, as determined by crevicular fluid molecular composition, differs from periodontal healing. The observed differences suggest that peri-implant tissues, compared to periodontal tissues, represent a higher pro-inflammatory state.</p>
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<name sortKey="Eubank, Tim D" sort="Eubank, Tim D" uniqKey="Eubank T" first="Tim D." last="Eubank">Tim D. Eubank</name>
<name sortKey="Leblebicioglu, Binnaz" sort="Leblebicioglu, Binnaz" uniqKey="Leblebicioglu B" first="Binnaz" last="Leblebicioglu">Binnaz Leblebicioglu</name>
<name sortKey="Shapiro, Vladimir" sort="Shapiro, Vladimir" uniqKey="Shapiro V" first="Vladimir" last="Shapiro">Vladimir Shapiro</name>
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PERI-IMPLANT VERSUS PERIODONTAL WOUND HEALING

PERI-IMPLANT VERSUS PERIODONTAL WOUND HEALING

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