Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
Identifieur interne : 003497 ( Ncbi/Checkpoint ); précédent : 003496; suivant : 003498Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
Auteurs : Wim Crielaard [Pays-Bas] ; Egija Zaura [Pays-Bas] ; Annemarie A. Schuller [Pays-Bas] ; Susan M. Huse [États-Unis] ; Roy C. Montijn [Pays-Bas] ; Bart Jf Keijser [Pays-Bas]Source :
- BMC Medical Genomics [ 1755-8794 ] ; 2011.
Abstract
An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural transition from their deciduous to a permanent dentition and related the microbial profiles to their oral health status. The microbial composition of saliva was assessed by barcoded pyrosequencing of the V5-V6 hypervariable regions of the 16 S rRNA, as well as by using phylogenetic microarrays.
Pyrosequencing reads (126174 reads, 1045 unique sequences) represented 8 phyla and 113 higher taxa in saliva samples. Four phyla - Firmicutes, Bacteriodetes, Proteobacteria and Actinobacteria - predominated in all groups. The deciduous dentition harboured a higher proportion of Proteobacteria (Gammaproteobacteria, Moraxellaceae) than Bacteroidetes, while in all other groups Bacteroidetes were at least as abundant as Proteobacteria. Bacteroidetes (mainly genus
Microarray analysis enabled further analysis of the individual salivary microbiota. Of 350 microarray probes, 156 gave a positive signal with, on average, 77 (range 48-93) probes per individual sample.
A caries-free oral status significantly associated with the higher signal of the probes targeting
The potential role of
Url:
DOI: 10.1186/1755-8794-4-22
PubMed: 21371338
PubMed Central: 3058002
Affiliations:
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PMC:3058002Le document en format XML
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<series><title level="j">BMC Medical Genomics</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural transition from their deciduous to a permanent dentition and related the microbial profiles to their oral health status. The microbial composition of saliva was assessed by barcoded pyrosequencing of the V5-V6 hypervariable regions of the 16 S rRNA, as well as by using phylogenetic microarrays.</p>
</sec>
<sec><title>Results</title>
<p>Pyrosequencing reads (126174 reads, 1045 unique sequences) represented 8 phyla and 113 higher taxa in saliva samples. Four phyla - Firmicutes, Bacteriodetes, Proteobacteria and Actinobacteria - predominated in all groups. The deciduous dentition harboured a higher proportion of Proteobacteria (Gammaproteobacteria, Moraxellaceae) than Bacteroidetes, while in all other groups Bacteroidetes were at least as abundant as Proteobacteria. Bacteroidetes (mainly genus <italic>Prevotella</italic>
), Veillonellaceae family, Spirochaetes and candidate division TM7 increased with increasing age, reflecting maturation of the microbiome driven by biological changes with age.</p>
<p>Microarray analysis enabled further analysis of the individual salivary microbiota. Of 350 microarray probes, 156 gave a positive signal with, on average, 77 (range 48-93) probes per individual sample.</p>
<p>A caries-free oral status significantly associated with the higher signal of the probes targeting <italic>Porphyromonas catoniae </italic>
and <italic>Neisseria flavescens</italic>
.</p>
</sec>
<sec><title>Conclusions</title>
<p>The potential role of <italic>P. catoniae </italic>
and <italic>N. flavescens </italic>
as oral health markers should be assessed in large-scale clinical studies. The combination of both, open-ended and targeted molecular approaches provides us with information that will increase our understanding of the interplay between the human host and its microbiome.</p>
</sec>
</div>
</front>
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