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Dental abnormalities associated with X-linked hypohidrotic ectodermal dysplasia in dogs

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Dental abnormalities associated with X-linked hypohidrotic ectodermal dysplasia in dogs

Auteurs : Jr Lewis [États-Unis] ; Am Reiter [États-Unis] ; Ea Mauldin [États-Unis] ; Ml Casal [États-Unis]

Source :

Orthodontics & craniofacial research [ 1601-6335 ] ; 2010.

RBID : PMC:2808637

Abstract

Objectives

X-linked hypohidrotic ectodermal dysplasia (XLHED) occurs in several species, including humans, mice, cattle and dogs. The orofacial manifestations of ectodermal dysplasia in humans and mice have been extensively studied, but documentation of dental abnormalities in dogs is lacking. The current study describes the results of clinical and radiographic examinations of XLHED-affected dogs and demonstrates profound similarities to findings of XLHED-affected humans.

Setting and sample population

Section of Medical Genetics at the University of Pennsylvania, School of Veterinary Medicine. Clinical and radiographic oral examinations were performed on 17 dogs with XLHED, 3 normal dogs, and 2 dogs heterozygous for XLHED.

Materials and methods

The prevalence and severity of orofacial and dental abnormalities were evaluated by means of a sedated examination, photographs, and full-mouth intraoral radiographs.

Results

Crown and root abnormalities were common in dogs affected by XLHED, including hypodontia, oligodontia, conical crown shape, decreased number of cusps, decreased number of roots, and dilacerated roots. Persistent deciduous teeth were frequently encountered. Malocclusion was common, with Angle Class I mesioversion of the maxillary and/or mandibular canine teeth noted in 15 of 17 dogs. Angle Class III malocclusion (maxillary brachygnathism) was seen in one affected dog.

Conclusion

Dental abnormalities are common and severe in dogs with XLHED. Dental manifestations of canine XLHED share characteristics of brachyodont tooth type and diphyodont dentition, confirming this species to be an orthologous animal model for study of human disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808637

DOI: 10.1111/j.1601-6343.2009.01473.x
PubMed: 20078794
PubMed Central: 2808637

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
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<p id="P4">Crown and root abnormalities were common in dogs affected by XLHED, including hypodontia, oligodontia, conical crown shape, decreased number of cusps, decreased number of roots, and dilacerated roots. Persistent deciduous teeth were frequently encountered. Malocclusion was common, with Angle Class I mesioversion of the maxillary and/or mandibular canine teeth noted in 15 of 17 dogs. Angle Class III malocclusion (maxillary brachygnathism) was seen in one affected dog.</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">Dental abnormalities are common and severe in dogs with XLHED. Dental manifestations of canine XLHED share characteristics of brachyodont tooth type and diphyodont dentition, confirming this species to be an orthologous animal model for study of human disease.</p>
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Dental abnormalities associated with X-linked hypohidrotic ectodermal dysplasia in dogs

Dental abnormalities associated with X-linked hypohidrotic ectodermal dysplasia in dogs

Source :

Abstract

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