Alveolar bone regeneration using absorbable poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor.
Identifieur interne : 002043 ( Ncbi/Checkpoint ); précédent : 002042; suivant : 002044Alveolar bone regeneration using absorbable poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor.
Auteurs : Y. Kinoshita [Japon] ; M. Matsuo ; K. Todoki ; S. Ozono ; S. Fukuoka ; H. Tsuzuki ; M. Nakamura ; K. Tomihata ; T. Shimamoto ; Y. IkadaSource :
- International journal of oral and maxillofacial surgery [ 0901-5027 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Chiens, Densité osseuse (physiologie), Facteur de croissance fibroblastique de type 2 (usage thérapeutique), Filet chirurgical, Hémostatiques (usage thérapeutique), Maladies mandibulaires (), Maladies mandibulaires (anatomopathologie), Maladies mandibulaires (physiopathologie), Mandibule (anatomopathologie), Mandibule (physiopathologie), Matériaux biocompatibles (), Membrane artificielle, Mâchoire édentée (), Mâchoire édentée (physiopathologie), Ostéogenèse (physiologie), Phosphates de calcium (), Polyesters (), Processus alvéolaire (anatomopathologie), Processus alvéolaire (physiopathologie), Régénération osseuse (physiologie), Régénération tissulaire guidée (), Résorption alvéolaire (), Résorption alvéolaire (anatomopathologie), Résorption alvéolaire (physiopathologie), Tomodensitométrie (), Éponge de gélatine résorbable (usage thérapeutique).
- MESH :
- anatomopathologie : Maladies mandibulaires, Mandibule, Processus alvéolaire, Résorption alvéolaire.
- physiologie : Densité osseuse, Ostéogenèse, Régénération osseuse.
- physiopathologie : Maladies mandibulaires, Mandibule, Mâchoire édentée, Processus alvéolaire, Résorption alvéolaire.
- usage thérapeutique : Facteur de croissance fibroblastique de type 2, Hémostatiques, Éponge de gélatine résorbable.
- Animaux, Chiens, Filet chirurgical, Maladies mandibulaires, Matériaux biocompatibles, Membrane artificielle, Mâchoire édentée, Phosphates de calcium, Polyesters, Régénération tissulaire guidée, Résorption alvéolaire, Tomodensitométrie.
English descriptors
- KwdEn :
- Alveolar Bone Loss (pathology), Alveolar Bone Loss (physiopathology), Alveolar Bone Loss (surgery), Alveolar Process (pathology), Alveolar Process (physiopathology), Animals, Biocompatible Materials (chemistry), Bone Density (physiology), Bone Regeneration (physiology), Calcium Phosphates (chemistry), Dogs, Fibroblast Growth Factor 2 (therapeutic use), Gelatin Sponge, Absorbable (therapeutic use), Guided Tissue Regeneration (methods), Hemostatics (therapeutic use), Jaw, Edentulous (physiopathology), Jaw, Edentulous (surgery), Mandible (pathology), Mandible (physiopathology), Mandibular Diseases (pathology), Mandibular Diseases (physiopathology), Mandibular Diseases (surgery), Membranes, Artificial, Osteogenesis (physiology), Polyesters (chemistry), Surgical Mesh, Tomography, X-Ray Computed (methods).
- MESH :
- chemical , chemistry : Biocompatible Materials, Calcium Phosphates, Polyesters.
- methods : Guided Tissue Regeneration, Tomography, X-Ray Computed.
- pathology : Alveolar Bone Loss, Alveolar Process, Mandible, Mandibular Diseases.
- physiology : Bone Density, Bone Regeneration, Osteogenesis.
- physiopathology : Alveolar Bone Loss, Alveolar Process, Jaw, Edentulous, Mandible, Mandibular Diseases.
- surgery : Alveolar Bone Loss, Jaw, Edentulous, Mandibular Diseases.
- chemical , therapeutic use : Fibroblast Growth Factor 2, Gelatin Sponge, Absorbable, Hemostatics.
- Animals, Dogs, Membranes, Artificial, Surgical Mesh.
Abstract
The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 microg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.
DOI: 10.1016/j.ijom.2007.11.010
PubMed: 18262760
Affiliations:
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Todoki</name></author><author><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S" last="Ozono">S. Ozono</name></author><author><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S" last="Fukuoka">S. Fukuoka</name></author><author><name sortKey="Tsuzuki, H" sort="Tsuzuki, H" uniqKey="Tsuzuki H" first="H" last="Tsuzuki">H. Tsuzuki</name></author><author><name sortKey="Nakamura, M" sort="Nakamura, M" uniqKey="Nakamura M" first="M" last="Nakamura">M. Nakamura</name></author><author><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K" last="Tomihata">K. Tomihata</name></author><author><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T" last="Shimamoto">T. Shimamoto</name></author><author><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y" last="Ikada">Y. 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Kinoshita</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Frontier Oral Science, Kanagawa Dental College, Yokosuka, Kanagawa, Japan. kinoshit@kdcnet.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Frontier Oral Science, Kanagawa Dental College, Yokosuka, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, M" sort="Matsuo, M" uniqKey="Matsuo M" first="M" last="Matsuo">M. Matsuo</name></author><author><name sortKey="Todoki, K" sort="Todoki, K" uniqKey="Todoki K" first="K" last="Todoki">K. Todoki</name></author><author><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S" last="Ozono">S. Ozono</name></author><author><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S" last="Fukuoka">S. Fukuoka</name></author><author><name sortKey="Tsuzuki, H" sort="Tsuzuki, H" uniqKey="Tsuzuki H" first="H" last="Tsuzuki">H. Tsuzuki</name></author><author><name sortKey="Nakamura, M" sort="Nakamura, M" uniqKey="Nakamura M" first="M" last="Nakamura">M. Nakamura</name></author><author><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K" last="Tomihata">K. Tomihata</name></author><author><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T" last="Shimamoto">T. Shimamoto</name></author><author><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y" last="Ikada">Y. Ikada</name></author></analytic><series><title level="j">International journal of oral and maxillofacial surgery</title><idno type="ISSN">0901-5027</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Bone Loss (pathology)</term><term>Alveolar Bone Loss (physiopathology)</term><term>Alveolar Bone Loss (surgery)</term><term>Alveolar Process (pathology)</term><term>Alveolar Process (physiopathology)</term><term>Animals</term><term>Biocompatible Materials (chemistry)</term><term>Bone Density (physiology)</term><term>Bone Regeneration (physiology)</term><term>Calcium Phosphates (chemistry)</term><term>Dogs</term><term>Fibroblast Growth Factor 2 (therapeutic use)</term><term>Gelatin Sponge, Absorbable (therapeutic use)</term><term>Guided Tissue Regeneration (methods)</term><term>Hemostatics (therapeutic use)</term><term>Jaw, Edentulous (physiopathology)</term><term>Jaw, Edentulous (surgery)</term><term>Mandible (pathology)</term><term>Mandible (physiopathology)</term><term>Mandibular Diseases (pathology)</term><term>Mandibular Diseases (physiopathology)</term><term>Mandibular Diseases (surgery)</term><term>Membranes, Artificial</term><term>Osteogenesis (physiology)</term><term>Polyesters (chemistry)</term><term>Surgical Mesh</term><term>Tomography, X-Ray Computed (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Densité osseuse (physiologie)</term><term>Facteur de croissance fibroblastique de type 2 (usage thérapeutique)</term><term>Filet chirurgical</term><term>Hémostatiques (usage thérapeutique)</term><term>Maladies mandibulaires ()</term><term>Maladies mandibulaires (anatomopathologie)</term><term>Maladies mandibulaires (physiopathologie)</term><term>Mandibule (anatomopathologie)</term><term>Mandibule (physiopathologie)</term><term>Matériaux biocompatibles ()</term><term>Membrane artificielle</term><term>Mâchoire édentée ()</term><term>Mâchoire édentée (physiopathologie)</term><term>Ostéogenèse (physiologie)</term><term>Phosphates de calcium ()</term><term>Polyesters ()</term><term>Processus alvéolaire (anatomopathologie)</term><term>Processus alvéolaire (physiopathologie)</term><term>Régénération osseuse (physiologie)</term><term>Régénération tissulaire guidée ()</term><term>Résorption alvéolaire ()</term><term>Résorption alvéolaire (anatomopathologie)</term><term>Résorption alvéolaire (physiopathologie)</term><term>Tomodensitométrie ()</term><term>Éponge de gélatine résorbable (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biocompatible Materials</term><term>Calcium Phosphates</term><term>Polyesters</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies 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alvéolaire</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alveolar Bone Loss</term><term>Alveolar Process</term><term>Jaw, Edentulous</term><term>Mandible</term><term>Mandibular Diseases</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Alveolar Bone Loss</term><term>Jaw, Edentulous</term><term>Mandibular Diseases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fibroblast Growth Factor 2</term><term>Gelatin Sponge, Absorbable</term><term>Hemostatics</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance fibroblastique de type 2</term><term>Hémostatiques</term><term>Éponge de gélatine résorbable</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Membranes, Artificial</term><term>Surgical Mesh</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Filet chirurgical</term><term>Maladies mandibulaires</term><term>Matériaux biocompatibles</term><term>Membrane artificielle</term><term>Mâchoire édentée</term><term>Phosphates de calcium</term><term>Polyesters</term><term>Régénération tissulaire guidée</term><term>Résorption alvéolaire</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 microg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S" last="Fukuoka">S. Fukuoka</name><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y" last="Ikada">Y. Ikada</name><name sortKey="Matsuo, M" sort="Matsuo, M" uniqKey="Matsuo M" first="M" last="Matsuo">M. Matsuo</name><name sortKey="Nakamura, M" sort="Nakamura, M" uniqKey="Nakamura M" first="M" last="Nakamura">M. Nakamura</name><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S" last="Ozono">S. Ozono</name><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T" last="Shimamoto">T. Shimamoto</name><name sortKey="Todoki, K" sort="Todoki, K" uniqKey="Todoki K" first="K" last="Todoki">K. Todoki</name><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K" last="Tomihata">K. Tomihata</name><name sortKey="Tsuzuki, H" sort="Tsuzuki, H" uniqKey="Tsuzuki H" first="H" last="Tsuzuki">H. Tsuzuki</name></noCountry><country name="Japon"><noRegion><name sortKey="Kinoshita, Y" sort="Kinoshita, Y" uniqKey="Kinoshita Y" first="Y" last="Kinoshita">Y. Kinoshita</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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