Changes in the density of protein gene product 9.5-immunoreactive nerve fibres in human oral mucosa under implant-retained overdentures.
Identifieur interne : 00A647 ( Main/Merge ); précédent : 00A646; suivant : 00A648Changes in the density of protein gene product 9.5-immunoreactive nerve fibres in human oral mucosa under implant-retained overdentures.
Auteurs : M. Garzino [Italie] ; G. Ramieri ; G. Panzica ; G. PretiSource :
- Archives of oral biology [ 0003-9969 ] ; 1996.
Descripteurs français
- KwdFr :
- Adaptation physiologique, Adulte, Adulte d'âge moyen, Denture, Humains, Immunohistochimie, Implants dentaires, Mandibule, Mastication, Muqueuse de la bouche (innervation), Mâchoire édentée (anatomopathologie), Neurofibres (métabolisme), Neurofibres (ultrastructure), Neurones afférents (ultrastructure), Overdenture, Phénomènes biomécaniques, Plasticité neuronale, Pose d'implant dentaire endo-osseux, Prothèse dentaire implanto-portée, Protéines de tissu nerveux (analyse), Sensation, Thiolester hydrolases (analyse), Ubiquitin thiolesterase.
- MESH :
- analyse : Protéines de tissu nerveux, Thiolester hydrolases.
- anatomopathologie : Mâchoire édentée.
- métabolisme : Neurofibres.
- Adaptation physiologique, Adulte, Adulte d'âge moyen, Denture, Humains, Immunohistochimie, Implants dentaires, Mandibule, Mastication, Muqueuse de la bouche, Neurofibres, Neurones afférents, Overdenture, Phénomènes biomécaniques, Plasticité neuronale, Pose d'implant dentaire endo-osseux, Prothèse dentaire implanto-portée, Sensation, Ubiquitin thiolesterase.
English descriptors
- KwdEn :
- Adaptation, Physiological, Adult, Biomechanical Phenomena, Dental Implantation, Endosseous, Dental Implants, Dental Prosthesis, Implant-Supported, Dentition, Denture, Overlay, Humans, Immunohistochemistry, Jaw, Edentulous (pathology), Mandible, Mastication, Middle Aged, Mouth Mucosa (innervation), Nerve Fibers (metabolism), Nerve Fibers (ultrastructure), Nerve Tissue Proteins (analysis), Neuronal Plasticity, Neurons, Afferent (ultrastructure), Sensation, Thiolester Hydrolases (analysis), Ubiquitin Thiolesterase.
- MESH :
- chemical , analysis : Nerve Tissue Proteins, Thiolester Hydrolases.
- chemical : Dental Implants, Ubiquitin Thiolesterase.
- innervation : Mouth Mucosa.
- metabolism : Nerve Fibers.
- pathology : Jaw, Edentulous.
- ultrastructure : Nerve Fibers, Neurons, Afferent.
- Adaptation, Physiological, Adult, Biomechanical Phenomena, Dental Implantation, Endosseous, Dental Prosthesis, Implant-Supported, Dentition, Denture, Overlay, Humans, Immunohistochemistry, Mandible, Mastication, Middle Aged, Neuronal Plasticity, Sensation.
Abstract
Reduced oral sensitivity and impaired masticatory cycles have been demonstrated in edentulous humans wearing removable dentures, and there is some evidence that these patients have a decreased innervation of the oral mucosa. Clinical and electrophysiological evidence shows that sensory performance improves after oral rehabilitation with implant-retained overdentures. The aim of this study was to compare the density of mucosal innervation in edentulous patients with that in dentate controls and to evaluate changes in the number or type of sensory receptors following placement of endosseous implants in these edentulous individuals. The mucosal innervation was evaluated by immunohistochemical assays for the neurospecific marker protein gene product 9.5, and the innervation pattern was compared with that of dentate controls. Morphometric analysis of the immunohistochemical material demonstrated a decrease in numbers of sensory receptors in the mucosa of edentulous patients and a significant increase in the number of nerve fibres in the mucosa covering the distal edentulous mandibular ridges supporting the prostheses after implant-retained rehabilitation. In contrast, there were only minor increases in the number of nerves in the peri-implant mucosa. These changes in innervation appear to be related either to the new biomechanical situation created by implant support, which favours more physiological tissue conditions, or to an adaptive mechanism in the peripheral processing of sensory stimuli. These changes may explain, at least partially, the clinically observed differences in sensory skills before and after implant placement.
PubMed: 9068871
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pubmed:9068871Le document en format XML
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Garzino</name><affiliation wicri:level="3"><nlm:affiliation>Chair of Prosthetic Dentistry, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Chair of Prosthetic Dentistry, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Ramieri, G" sort="Ramieri, G" uniqKey="Ramieri G" first="G" last="Ramieri">G. Ramieri</name></author><author><name sortKey="Panzica, G" sort="Panzica, G" uniqKey="Panzica G" first="G" last="Panzica">G. Panzica</name></author><author><name sortKey="Preti, G" sort="Preti, G" uniqKey="Preti G" first="G" last="Preti">G. Preti</name></author></analytic><series><title level="j">Archives of oral biology</title><idno type="ISSN">0003-9969</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological</term><term>Adult</term><term>Biomechanical Phenomena</term><term>Dental Implantation, Endosseous</term><term>Dental Implants</term><term>Dental Prosthesis, Implant-Supported</term><term>Dentition</term><term>Denture, Overlay</term><term>Humans</term><term>Immunohistochemistry</term><term>Jaw, Edentulous (pathology)</term><term>Mandible</term><term>Mastication</term><term>Middle Aged</term><term>Mouth Mucosa (innervation)</term><term>Nerve Fibers (metabolism)</term><term>Nerve Fibers (ultrastructure)</term><term>Nerve Tissue Proteins (analysis)</term><term>Neuronal Plasticity</term><term>Neurons, Afferent (ultrastructure)</term><term>Sensation</term><term>Thiolester Hydrolases (analysis)</term><term>Ubiquitin Thiolesterase</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Denture</term><term>Humains</term><term>Immunohistochimie</term><term>Implants dentaires</term><term>Mandibule</term><term>Mastication</term><term>Muqueuse de la bouche (innervation)</term><term>Mâchoire édentée (anatomopathologie)</term><term>Neurofibres (métabolisme)</term><term>Neurofibres (ultrastructure)</term><term>Neurones afférents (ultrastructure)</term><term>Overdenture</term><term>Phénomènes biomécaniques</term><term>Plasticité neuronale</term><term>Pose d'implant dentaire endo-osseux</term><term>Prothèse dentaire implanto-portée</term><term>Protéines de tissu nerveux (analyse)</term><term>Sensation</term><term>Thiolester hydrolases (analyse)</term><term>Ubiquitin thiolesterase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nerve Tissue Proteins</term><term>Thiolester Hydrolases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term><term>Ubiquitin Thiolesterase</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines de tissu nerveux</term><term>Thiolester hydrolases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mâchoire édentée</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Mouth Mucosa</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Nerve Fibers</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Neurofibres</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nerve Fibers</term><term>Neurons, Afferent</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term><term>Adult</term><term>Biomechanical Phenomena</term><term>Dental Implantation, Endosseous</term><term>Dental Prosthesis, Implant-Supported</term><term>Dentition</term><term>Denture, Overlay</term><term>Humans</term><term>Immunohistochemistry</term><term>Mandible</term><term>Mastication</term><term>Middle Aged</term><term>Neuronal Plasticity</term><term>Sensation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Denture</term><term>Humains</term><term>Immunohistochimie</term><term>Implants dentaires</term><term>Mandibule</term><term>Mastication</term><term>Muqueuse de la bouche</term><term>Neurofibres</term><term>Neurones afférents</term><term>Overdenture</term><term>Phénomènes biomécaniques</term><term>Plasticité neuronale</term><term>Pose d'implant dentaire endo-osseux</term><term>Prothèse dentaire implanto-portée</term><term>Sensation</term><term>Ubiquitin thiolesterase</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reduced oral sensitivity and impaired masticatory cycles have been demonstrated in edentulous humans wearing removable dentures, and there is some evidence that these patients have a decreased innervation of the oral mucosa. Clinical and electrophysiological evidence shows that sensory performance improves after oral rehabilitation with implant-retained overdentures. The aim of this study was to compare the density of mucosal innervation in edentulous patients with that in dentate controls and to evaluate changes in the number or type of sensory receptors following placement of endosseous implants in these edentulous individuals. The mucosal innervation was evaluated by immunohistochemical assays for the neurospecific marker protein gene product 9.5, and the innervation pattern was compared with that of dentate controls. Morphometric analysis of the immunohistochemical material demonstrated a decrease in numbers of sensory receptors in the mucosa of edentulous patients and a significant increase in the number of nerve fibres in the mucosa covering the distal edentulous mandibular ridges supporting the prostheses after implant-retained rehabilitation. In contrast, there were only minor increases in the number of nerves in the peri-implant mucosa. These changes in innervation appear to be related either to the new biomechanical situation created by implant support, which favours more physiological tissue conditions, or to an adaptive mechanism in the peripheral processing of sensory stimuli. These changes may explain, at least partially, the clinically observed differences in sensory skills before and after implant placement.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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