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Genetic and environmental influences in sleep-disordered breathing in older male twins

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Genetic and environmental influences in sleep-disordered breathing in older male twins

Auteurs : Dorit Carmelli [États-Unis] ; Ian M. Colrain [États-Unis, Australie] ; Gary E. Swan [États-Unis] ; Donald L. Bliwise [États-Unis]

Source :

Sleep : (New York, NY) [ 0161-8105 ] ; 2004.

RBID : Pascal:04-0506966

Descripteurs français

Pascal (Inist)
- Trouble sommeil, Ronflement, Respiration, Sénescence, Environnement, Déterminisme génétique, Homme, Jumeau.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Environment, Genetic determinism, Human, Respiration, Senescence, Sleep disorder, Snoring, Twin.

Abstract

Study Objectives: To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins. Design and Setting: A biometric genetic study based on data from unattended Edentrace recordings in a sample of elderly male twins. Participants: 122 World War II male veteran twin pairs, including 68 monozygotic pairs aged 78.9 (± 2.7) years and 54 dizygotic pairs aged 78.4 (± 2.4) years. Interventions: N/A. Measurements and Results: The average (± SD) respiratory disturbance index for this sample was 17.2 ± 14.5, the average (± SD) oxygen desaturation index was 18.8 ± 16.4, and the average (± SD) minimum SaO₂ level was 79.6 ± 8.1%. Intraclass twin-pair correlations for log-transformed respiratory disturbance index were 0.59 in monozygotic pairs and 0.36 in dizygotic pairs. For oxygen desaturation index, intraclass correlations were 0.44 in monozygotic pairs and 0.24 in dizygotic pairs. For minimum SaO₂, intraclass correlations were 0.38 and 0.11, respectively. Maximum likelihood estimates of heritability with associated 95% confidence intervals were 37% [22%, 52%] for respiratory disturbance index, 36% [19%, 53%] for oxygen desaturation index, and 10% [0%, 30%] for minimum SaO₂. Adjustments of sleep-disordered breathing measures for age, body mass index, and waist and neck circumference had minimal effect on estimates of heritability. Conclusions. The present data indicate that sleep-disordered breathing, even in old age, is determined, in part, by genetic factors.

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Le document en format XML

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<term>Genetic determinism</term>
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<term>Respiration</term>
<term>Senescence</term>
<term>Sleep disorder</term>
<term>Snoring</term>
<term>Twin</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Trouble sommeil</term>
<term>Ronflement</term>
<term>Respiration</term>
<term>Sénescence</term>
<term>Environnement</term>
<term>Déterminisme génétique</term>
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<front><div type="abstract" xml:lang="en">Study Objectives: To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins. Design and Setting: A biometric genetic study based on data from unattended Edentrace recordings in a sample of elderly male twins. Participants: 122 World War II male veteran twin pairs, including 68 monozygotic pairs aged 78.9 (± 2.7) years and 54 dizygotic pairs aged 78.4 (± 2.4) years. Interventions: N/A. Measurements and Results: The average (± SD) respiratory disturbance index for this sample was 17.2 ± 14.5, the average (± SD) oxygen desaturation index was 18.8 ± 16.4, and the average (± SD) minimum SaO<sub>2</sub>
 level was 79.6 ± 8.1%. Intraclass twin-pair correlations for log-transformed respiratory disturbance index were 0.59 in monozygotic pairs and 0.36 in dizygotic pairs. For oxygen desaturation index, intraclass correlations were 0.44 in monozygotic pairs and 0.24 in dizygotic pairs. For minimum SaO<sub>2</sub>
, intraclass correlations were 0.38 and 0.11, respectively. Maximum likelihood estimates of heritability with associated 95% confidence intervals were 37% [22%, 52%] for respiratory disturbance index, 36% [19%, 53%] for oxygen desaturation index, and 10% [0%, 30%] for minimum SaO<sub>2</sub>
. Adjustments of sleep-disordered breathing measures for age, body mass index, and waist and neck circumference had minimal effect on estimates of heritability. Conclusions. The present data indicate that sleep-disordered breathing, even in old age, is determined, in part, by genetic factors.</div>
</front>
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<name sortKey="Swan, Gary E" sort="Swan, Gary E" uniqKey="Swan G" first="Gary E." last="Swan">Gary E. Swan</name>
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<country name="Australie"><noRegion><name sortKey="Colrain, Ian M" sort="Colrain, Ian M" uniqKey="Colrain I" first="Ian M." last="Colrain">Ian M. Colrain</name>
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Genetic and environmental influences in sleep-disordered breathing in older male twins

Genetic and environmental influences in sleep-disordered breathing in older male twins

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri