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Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?

Identifieur interne : 006C39 ( Main/Merge ); précédent : 006C38; suivant : 006C40

Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?

Auteurs : Daniel T. Chang [États-Unis] ; Pamela R. Sandow [États-Unis] ; Christopher G. Morris [États-Unis] ; Rachel Hollander [États-Unis] ; Lauren Scarborough [États-Unis] ; Robert J. Amdur [États-Unis] ; William M. Mendenhall [États-Unis]

Source :

Head & neck [ 1043-3074 ] ; 2007.

RBID : Pascal:07-0267136

Descripteurs français

Pascal (Inist)
- Ostéonécrose, Radiolésion, Radiothérapie, Traitement, Dent, Extraction, Facteur risque, Risque, Mandibule, Stomatologie, Cancer de la tête et du cou.

English descriptors

KwdEn :
- Extraction, Head and neck cancer, Mandible, Osteonecrosis, Radiation injury, Radiotherapy, Risk, Risk factor, Stomatology, Tooth, Treatment.

Abstract

Background. This study was done to determine if pre-radiotherapy (pre-RT) dental extractions reduce the risk of osteoradionecrosis (ORN). Methods. Between 1987 and 2004, 413 patients with oropharyngeal carcinomas were treated with definitive RT at the University of Florida. Dentate patients underwent pretreatment dental evaluation. Teeth in the RT field were usually extracted if thought to have poor long-term prognosis from dental disease. The endpoint was >grade 2 ORN using a modified staging system Patients were excluded for local recurrence, additional RT above the clavicles, or head and neck surgery besides neck dissection. Results. ORN rates were as follows: edentulous, <1%; teeth in-field with pre-RT extractions, 15%; and teeth in-field without pre-RT extractions, 9%. Patients with poor in-field teeth and pre-RT extractions had a higher 5-year incidence of ORN than those who did not have pre-RT extractions (16% vs 6%, p =.48). Likewise, for those with in-field teeth in good condition and pre-RT extractions, the 5-year ORN incidence was higher than for those who did not undergo extractions (15% vs 2%, p =.42). Multivariate analysis revealed increased ORN risk with doses of >70 Gy, once-daily fractionation, or brachytherapy Conclusion. Pre-RT extractions do not appear to reduce the risk of ORN.

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Extraction</term>
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<term>Radiation injury</term>
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<term>Risk</term>
<term>Risk factor</term>
<term>Stomatology</term>
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<term>Extraction</term>
<term>Facteur risque</term>
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<front><div type="abstract" xml:lang="en">Background. This study was done to determine if pre-radiotherapy (pre-RT) dental extractions reduce the risk of osteoradionecrosis (ORN). Methods. Between 1987 and 2004, 413 patients with oropharyngeal carcinomas were treated with definitive RT at the University of Florida. Dentate patients underwent pretreatment dental evaluation. Teeth in the RT field were usually extracted if thought to have poor long-term prognosis from dental disease. The endpoint was >grade 2 ORN using a modified staging system Patients were excluded for local recurrence, additional RT above the clavicles, or head and neck surgery besides neck dissection. Results. ORN rates were as follows: edentulous, <1%; teeth in-field with pre-RT extractions, 15%; and teeth in-field without pre-RT extractions, 9%. Patients with poor in-field teeth and pre-RT extractions had a higher 5-year incidence of ORN than those who did not have pre-RT extractions (16% vs 6%, p =.48). Likewise, for those with in-field teeth in good condition and pre-RT extractions, the 5-year ORN incidence was higher than for those who did not undergo extractions (15% vs 2%, p =.42). Multivariate analysis revealed increased ORN risk with doses of >70 Gy, once-daily fractionation, or brachytherapy Conclusion. Pre-RT extractions do not appear to reduce the risk of ORN.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Amdur, Robert J" sort="Amdur, Robert J" uniqKey="Amdur R" first="Robert J." last="Amdur">Robert J. Amdur</name>
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<name sortKey="Morris, Christopher G" sort="Morris, Christopher G" uniqKey="Morris C" first="Christopher G." last="Morris">Christopher G. Morris</name>
<name sortKey="Sandow, Pamela R" sort="Sandow, Pamela R" uniqKey="Sandow P" first="Pamela R." last="Sandow">Pamela R. Sandow</name>
<name sortKey="Scarborough, Lauren" sort="Scarborough, Lauren" uniqKey="Scarborough L" first="Lauren" last="Scarborough">Lauren Scarborough</name>
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Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?

Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri