Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins
Identifieur interne : 006743 ( Main/Merge ); précédent : 006742; suivant : 006744Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins
Auteurs : Tahwinder Upile [Royaume-Uni] ; Cyril Fisher [Royaume-Uni] ; Waseem Jerjes [Royaume-Uni] ; Mohammed El Maaytah [Royaume-Uni] ; Sandeep Singh [Royaume-Uni] ; Holger Sudhoff [Royaume-Uni] ; Adam Searle [Royaume-Uni] ; Daniel Archer [Royaume-Uni] ; Leslie Michaels [Royaume-Uni] ; Colin Hopper [Royaume-Uni] ; Peter Rhys-Evans [Royaume-Uni] ; David Howard [Royaume-Uni] ; Anthony Wright [Royaume-Uni]Source :
- Head & Face Medicine [ 1746-160X ] ; 2007.
Abstract
The tumour margin is an important surgical concept significantly affecting patient morbidity and mortality. We aimed in this prospective study to apply the microendoscope on tissue margins from patients undergoing surgery for oral cancer
Forty patients undergoing resection of oral squamous cell carcinoma were recruited. The surgical margin was first marked by the operator followed by microendoscopic assessment. Biopsies were taken from areas suggestive of close or positive margins after microendoscopic examination. These histological samples were later scrutinized formally and the resection margins revisited accordingly when necessary.
Using the microendoscope we report our experience in the determination of surgical margins at operation and later comparison with frozen section and paraffin section margins "gold standard". We were able to obtain a sensitivity of 95% and a specificity of 90%. Inter-observer Kappa scores comparing the microendoscope with formal histological analysis of normal and abnormal mucosa were 0.85.
The advantage of this technique is that a large area of mucosa can be sampled and any histomorphological changes can be visualized in real time allowing the operator to make important informed decisions with regards the intra-operative resection margin at the time of the surgery.
Url:
DOI: 10.1186/1746-160X-3-13
PubMed: 17331229
PubMed Central: 1819375
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001871
- to stream Pmc, to step Curation: 001871
- to stream Pmc, to step Checkpoint: 002677
- to stream Ncbi, to step Merge: 001C02
- to stream Ncbi, to step Curation: 001C02
- to stream Ncbi, to step Checkpoint: 001C02
Links to Exploration step
PMC:1819375Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent technological developments: <italic>in situ </italic>
histopathological interrogation of surgical tissues and resection margins</title>
<author><name sortKey="Upile, Tahwinder" sort="Upile, Tahwinder" uniqKey="Upile T" first="Tahwinder" last="Upile">Tahwinder Upile</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Department of Histopathology, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Histopathology, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jerjes, Waseem" sort="Jerjes, Waseem" uniqKey="Jerjes W" first="Waseem" last="Jerjes">Waseem Jerjes</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I8">National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="El Maaytah, Mohammed" sort="El Maaytah, Mohammed" uniqKey="El Maaytah M" first="Mohammed" last="El Maaytah">Mohammed El Maaytah</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singh, Sandeep" sort="Singh, Sandeep" uniqKey="Singh S" first="Sandeep" last="Singh">Sandeep Singh</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sudhoff, Holger" sort="Sudhoff, Holger" uniqKey="Sudhoff H" first="Holger" last="Sudhoff">Holger Sudhoff</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Searle, Adam" sort="Searle, Adam" uniqKey="Searle A" first="Adam" last="Searle">Adam Searle</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Department of Plastic and Reconstructive Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Plastic and Reconstructive Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Archer, Daniel" sort="Archer, Daniel" uniqKey="Archer D" first="Daniel" last="Archer">Daniel Archer</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michaels, Leslie" sort="Michaels, Leslie" uniqKey="Michaels L" first="Leslie" last="Michaels">Leslie Michaels</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, Colin" sort="Hopper, Colin" uniqKey="Hopper C" first="Colin" last="Hopper">Colin Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I8">National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rhys Evans, Peter" sort="Rhys Evans, Peter" uniqKey="Rhys Evans P" first="Peter" last="Rhys-Evans">Peter Rhys-Evans</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Howard, David" sort="Howard, David" uniqKey="Howard D" first="David" last="Howard">David Howard</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Anthony" sort="Wright, Anthony" uniqKey="Wright A" first="Anthony" last="Wright">Anthony Wright</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17331229</idno>
<idno type="pmc">1819375</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819375</idno>
<idno type="RBID">PMC:1819375</idno>
<idno type="doi">10.1186/1746-160X-3-13</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">001871</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001871</idno>
<idno type="wicri:Area/Pmc/Curation">001871</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001871</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002677</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002677</idno>
<idno type="wicri:Area/Ncbi/Merge">001C02</idno>
<idno type="wicri:Area/Ncbi/Curation">001C02</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C02</idno>
<idno type="wicri:Area/Main/Merge">006743</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent technological developments: <italic>in situ </italic>
histopathological interrogation of surgical tissues and resection margins</title>
<author><name sortKey="Upile, Tahwinder" sort="Upile, Tahwinder" uniqKey="Upile T" first="Tahwinder" last="Upile">Tahwinder Upile</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name>
<affiliation wicri:level="3"><nlm:aff id="I2">Department of Histopathology, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Histopathology, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jerjes, Waseem" sort="Jerjes, Waseem" uniqKey="Jerjes W" first="Waseem" last="Jerjes">Waseem Jerjes</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I8">National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="El Maaytah, Mohammed" sort="El Maaytah, Mohammed" uniqKey="El Maaytah M" first="Mohammed" last="El Maaytah">Mohammed El Maaytah</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singh, Sandeep" sort="Singh, Sandeep" uniqKey="Singh S" first="Sandeep" last="Singh">Sandeep Singh</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sudhoff, Holger" sort="Sudhoff, Holger" uniqKey="Sudhoff H" first="Holger" last="Sudhoff">Holger Sudhoff</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Searle, Adam" sort="Searle, Adam" uniqKey="Searle A" first="Adam" last="Searle">Adam Searle</name>
<affiliation wicri:level="3"><nlm:aff id="I4">Department of Plastic and Reconstructive Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Plastic and Reconstructive Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Archer, Daniel" sort="Archer, Daniel" uniqKey="Archer D" first="Daniel" last="Archer">Daniel Archer</name>
<affiliation wicri:level="3"><nlm:aff id="I5">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michaels, Leslie" sort="Michaels, Leslie" uniqKey="Michaels L" first="Leslie" last="Michaels">Leslie Michaels</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, Colin" sort="Hopper, Colin" uniqKey="Hopper C" first="Colin" last="Hopper">Colin Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute & University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I7">Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oral & Maxillofacial Surgery/Head & Neck Unit, University College London Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="I8">National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Medical Laser Centre, Department of Surgery, Royal Free & University College Medical School, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rhys Evans, Peter" sort="Rhys Evans, Peter" uniqKey="Rhys Evans P" first="Peter" last="Rhys-Evans">Peter Rhys-Evans</name>
<affiliation wicri:level="3"><nlm:aff id="I1">Department of Head & Neck Surgery, the Royal Marsden Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Howard, David" sort="Howard, David" uniqKey="Howard D" first="David" last="Howard">David Howard</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Anthony" sort="Wright, Anthony" uniqKey="Wright A" first="Anthony" last="Wright">Anthony Wright</name>
<affiliation wicri:level="3"><nlm:aff id="I6">Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Head & Neck Surgery, the Professorial Unit, the Royal National Throat, Nose and Ear Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Head & Face Medicine</title>
<idno type="eISSN">1746-160X</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>The tumour margin is an important surgical concept significantly affecting patient morbidity and mortality. We aimed in this prospective study to apply the microendoscope on tissue margins from patients undergoing surgery for oral cancer <italic>in vivo </italic>
and <italic>ex vivo </italic>
and compare it to the gold standard "paraffin wax", inter-observer agreement was measured; also to present the surgical pathologist with a practical guide to the every day use of the microendoscope both in the clinical and surgical fields.</p>
</sec>
<sec sec-type="materials|methods"><title>Materials and methods</title>
<p>Forty patients undergoing resection of oral squamous cell carcinoma were recruited. The surgical margin was first marked by the operator followed by microendoscopic assessment. Biopsies were taken from areas suggestive of close or positive margins after microendoscopic examination. These histological samples were later scrutinized formally and the resection margins revisited accordingly when necessary.</p>
</sec>
<sec><title>Results</title>
<p>Using the microendoscope we report our experience in the determination of surgical margins at operation and later comparison with frozen section and paraffin section margins "gold standard". We were able to obtain a sensitivity of 95% and a specificity of 90%. Inter-observer Kappa scores comparing the microendoscope with formal histological analysis of normal and abnormal mucosa were 0.85.</p>
</sec>
<sec><title>Conclusion</title>
<p>The advantage of this technique is that a large area of mucosa can be sampled and any histomorphological changes can be visualized in real time allowing the operator to make important informed decisions with regards the intra-operative resection margin at the time of the surgery.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006743 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006743 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Merge |type= RBID |clé= PMC:1819375 |texte= Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:17331229" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |