Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth
Identifieur interne : 006651 ( Main/Merge ); précédent : 006650; suivant : 006652Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth
Auteurs : Y. Kinoshita [Japon] ; M. Matsuo [Japon] ; K. Todoki [Japon] ; S. Ozono [Japon] ; S. Fukuoka [Japon] ; H. Tsuzuki [Japon] ; M. Nakamura [Japon] ; K. Tomihata [Japon] ; T. Shimamoto [Japon] ; Y. Ikada [Japon]Source :
- International journal of oral and maxillofacial surgery [ 0901-5027 ] ; 2008.
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Abstract
The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth</title><author><name sortKey="Kinoshita, Y" sort="Kinoshita, Y" uniqKey="Kinoshita Y" first="Y." last="Kinoshita">Y. Kinoshita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, M" sort="Matsuo, M" uniqKey="Matsuo M" first="M." last="Matsuo">M. Matsuo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Todoki, K" sort="Todoki, K" uniqKey="Todoki K" first="K." last="Todoki">K. Todoki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S." last="Ozono">S. Ozono</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S." last="Fukuoka">S. 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Nakamura</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K." last="Tomihata">K. Tomihata</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Material Center, Research & Development Center, Gunze Ltd</s1><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Medical Material Center, Research & Development Center, Gunze Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T." last="Shimamoto">T. Shimamoto</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Material Center, Research & Development Center, Gunze Ltd</s1><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Medical Material Center, Research & Development Center, Gunze Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y." last="Ikada">Y. Ikada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Nara Medical University</s1><s2>Nara</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Nara Medical University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0183378</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0183378 INIST</idno><idno type="RBID">Pascal:08-0183378</idno><idno type="wicri:Area/PascalFrancis/Corpus">000379</idno><idno type="wicri:Area/PascalFrancis/Curation">000323</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000379</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000379</idno><idno type="wicri:doubleKey">0901-5027:2008:Kinoshita Y:alveolar:bone:regeneration</idno><idno type="wicri:Area/Main/Merge">006651</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Alveolar bone regeneration using absorbable poly(L-lactide-co-ε-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth</title><author><name sortKey="Kinoshita, Y" sort="Kinoshita, Y" uniqKey="Kinoshita Y" first="Y." last="Kinoshita">Y. Kinoshita</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Matsuo, M" sort="Matsuo, M" uniqKey="Matsuo M" first="M." last="Matsuo">M. Matsuo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Todoki, K" sort="Todoki, K" uniqKey="Todoki K" first="K." last="Todoki">K. Todoki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S." last="Ozono">S. Ozono</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S." last="Fukuoka">S. Fukuoka</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Tsuzuki, H" sort="Tsuzuki, H" uniqKey="Tsuzuki H" first="H." last="Tsuzuki">H. Tsuzuki</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, M" sort="Nakamura, M" uniqKey="Nakamura M" first="M." last="Nakamura">M. Nakamura</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K." last="Tomihata">K. Tomihata</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Material Center, Research & Development Center, Gunze Ltd</s1><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Medical Material Center, Research & Development Center, Gunze Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T." last="Shimamoto">T. Shimamoto</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical Material Center, Research & Development Center, Gunze Ltd</s1><s3>JPN</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Medical Material Center, Research & Development Center, Gunze Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y." last="Ikada">Y. Ikada</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute for Frontier Oral Science, Kanagawa Dental College</s1><s2>Yokosuka, Kanagawa</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokosuka, Kanagawa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Nara Medical University</s1><s2>Nara</s2><s3>JPN</s3><sZ>10 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Nara Medical University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of oral and maxillofacial surgery</title><title level="j" type="abbreviated">Int. j. oral maxillofac. surg.</title><idno type="ISSN">0901-5027</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of oral and maxillofacial surgery</title><title level="j" type="abbreviated">Int. j. oral maxillofac. surg.</title><idno type="ISSN">0901-5027</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorbable</term><term>Alveolar bone</term><term>Basic fibroblast growth factor</term><term>Fibroblast</term><term>Gelatin</term><term>Growth</term><term>Guidance</term><term>Lactic acid polymer</term><term>Phosphates</term><term>Regeneration</term><term>Sponge</term><term>Stomatology</term><term>Surgery</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie</term><term>Os alvéolaire</term><term>Régénération</term><term>Résorbable</term><term>Lactique acide polymère</term><term>Phosphate</term><term>Gélatine</term><term>Eponge</term><term>Fibroblaste</term><term>Croissance</term><term>Guidage</term><term>Facteur croissance fibroblaste basique</term><term>Stomatologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Phosphate</term><term>Gélatine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10 mm long x 5 mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200 μg bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-e-caprolactone)/(β-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kinoshita, Y" sort="Kinoshita, Y" uniqKey="Kinoshita Y" first="Y." last="Kinoshita">Y. Kinoshita</name></noRegion><name sortKey="Fukuoka, S" sort="Fukuoka, S" uniqKey="Fukuoka S" first="S." last="Fukuoka">S. Fukuoka</name><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y." last="Ikada">Y. Ikada</name><name sortKey="Ikada, Y" sort="Ikada, Y" uniqKey="Ikada Y" first="Y." last="Ikada">Y. Ikada</name><name sortKey="Matsuo, M" sort="Matsuo, M" uniqKey="Matsuo M" first="M." last="Matsuo">M. Matsuo</name><name sortKey="Nakamura, M" sort="Nakamura, M" uniqKey="Nakamura M" first="M." last="Nakamura">M. Nakamura</name><name sortKey="Ozono, S" sort="Ozono, S" uniqKey="Ozono S" first="S." last="Ozono">S. Ozono</name><name sortKey="Shimamoto, T" sort="Shimamoto, T" uniqKey="Shimamoto T" first="T." last="Shimamoto">T. Shimamoto</name><name sortKey="Todoki, K" sort="Todoki, K" uniqKey="Todoki K" first="K." last="Todoki">K. Todoki</name><name sortKey="Tomihata, K" sort="Tomihata, K" uniqKey="Tomihata K" first="K." last="Tomihata">K. Tomihata</name><name sortKey="Tsuzuki, H" sort="Tsuzuki, H" uniqKey="Tsuzuki H" first="H." last="Tsuzuki">H. Tsuzuki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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