A Clinical Comparison of Cenobone (A Decalcified Freeze-dried Bone Allograft) with Autogenous Bone Graft in the Treatment of Two- and Three-wall Intrabony Periodontal Defects: A Human Study with Six-month Reentry
Identifieur interne : 006204 ( Main/Merge ); précédent : 006203; suivant : 006205A Clinical Comparison of Cenobone (A Decalcified Freeze-dried Bone Allograft) with Autogenous Bone Graft in the Treatment of Two- and Three-wall Intrabony Periodontal Defects: A Human Study with Six-month Reentry
Auteurs : Nader Abolfazli [Iran] ; Fariba Saleh Saber [Iran] ; Ardeshir Lafzi [Iran] ; Amir Eskandari [Iran] ; Sarah Mehrasbi [Iran]Source :
- Journal of Dental Research, Dental Clinics, Dental Prospects [ 2008-210X ] ; 2008.
Abstract
Complete and predictable regeneration of tissue lost as a result of infection or trauma is the ultimate goal of periodontal therapy. Various graft materials have been successfully used in the treatment of intrabony defects. The purpose of this study was to evaluate the use of a decalcified freeze-dried bone allograft (Cerabone) with the autogenous bone graft as a gold standard in the treatment of human two- or three-wall intrabony periodontal defects.
This split-mouth study was done on 10 pairs of matched two- or three-wall intrabony periodontal defects with 5 mm or more probing depth and 3 mm or more depth of intrabony component following phase I therapy. In the control sites autogenous bone graft and in the test sites decalcified freeze-dried bone allograft were used.
At baseline, no significant differences were found in terms of oral hygiene and defect charac-teristics. At six months, analysis showed a significant improvement in soft and hard tissue parameters for both treatment groups as compared to preoperative measurements. There were no statistical differ-ences in clinically-measured parameters between treatment groups after 6 months except for crestal resorption that increased significantly in control group (P = 0.25). Defect resolution and bone fill in the test and control groups were 2.5 ± 0.46 mm versus 2.7 ± 0.73 mm and 2 ± 0.62 mm versus 2.20 ± 0.52 mm, respectively.
The results of this study demonstrated that both graft materials improved clinical parameters. The comparison of the two treatment groups did not show any significant differences in clinical parameters after six months. However, because of the limited amount of intra-oral donor bone, it is preferable to use decalcified freeze-dried bone allograft.
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DOI: 10.5681/joddd.2008.001
PubMed: 23285322
PubMed Central: 3533631
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Saber">Fariba Saleh Saber</name><affiliation wicri:level="1"><nlm:aff id="A02">Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lafzi, Ardeshir" sort="Lafzi, Ardeshir" uniqKey="Lafzi A" first="Ardeshir" last="Lafzi">Ardeshir Lafzi</name><affiliation wicri:level="1"><nlm:aff id="A03">Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Eskandari, Amir" sort="Eskandari, Amir" uniqKey="Eskandari A" first="Amir" last="Eskandari">Amir Eskandari</name><affiliation wicri:level="1"><nlm:aff id="A01">Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Mehrasbi, Sarah" sort="Mehrasbi, Sarah" uniqKey="Mehrasbi S" first="Sarah" last="Mehrasbi">Sarah Mehrasbi</name><affiliation wicri:level="1"><nlm:aff id="A02">Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country 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xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Saleh Saber, Fariba" sort="Saleh Saber, Fariba" uniqKey="Saleh Saber F" first="Fariba" last="Saleh Saber">Fariba Saleh Saber</name><affiliation wicri:level="1"><nlm:aff id="A02">Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lafzi, Ardeshir" sort="Lafzi, Ardeshir" uniqKey="Lafzi A" first="Ardeshir" last="Lafzi">Ardeshir Lafzi</name><affiliation wicri:level="1"><nlm:aff id="A03">Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Eskandari, Amir" sort="Eskandari, Amir" uniqKey="Eskandari A" first="Amir" last="Eskandari">Amir Eskandari</name><affiliation wicri:level="1"><nlm:aff id="A01">Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Mehrasbi, Sarah" sort="Mehrasbi, Sarah" uniqKey="Mehrasbi S" first="Sarah" last="Mehrasbi">Sarah Mehrasbi</name><affiliation wicri:level="1"><nlm:aff id="A02">Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences</wicri:regionArea><wicri:noRegion>Tabriz University of Medical Sciences</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Dental Research, Dental Clinics, Dental Prospects</title><idno type="ISSN">2008-210X</idno><idno type="eISSN">2008-2118</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1" sec-type="Background and aims"><title>Background and aims</title><p>Complete and predictable regeneration of tissue lost as a result of infection or trauma is the ultimate goal of periodontal therapy. Various graft materials have been successfully used in the treatment of intrabony defects. The purpose of this study was to evaluate the use of a decalcified freeze-dried bone allograft (Cerabone) with the autogenous bone graft as a gold standard in the treatment of human two- or three-wall intrabony periodontal defects.
</p></sec><sec id="st2" sec-type="Materials and methods"><title>Materials and methods</title><p>This split-mouth study was done on 10 pairs of matched two- or three-wall intrabony periodontal defects with 5 mm or more probing depth and 3 mm or more depth of intrabony component following phase I therapy. In the control sites autogenous bone graft and in the test sites decalcified freeze-dried bone allograft were used.
</p></sec><sec id="st3" sec-type="Results"><title>Results</title><p>At baseline, no significant differences were found in terms of oral hygiene and defect charac-teristics. At six months, analysis showed a significant improvement in soft and hard tissue parameters for both treatment groups as compared to preoperative measurements. There were no statistical differ-ences in clinically-measured parameters between treatment groups after 6 months except for crestal resorption that increased significantly in control group (P = 0.25). Defect resolution and bone fill in the test and control groups were 2.5 ± 0.46 mm versus 2.7 ± 0.73 mm and 2 ± 0.62 mm versus 2.20 ± 0.52 mm, respectively.
</p></sec><sec id="st4" sec-type="Conclusion"><title>Conclusion</title><p> The results of this study demonstrated that both graft materials improved clinical parameters. The comparison of the two treatment groups did not show any significant differences in clinical parameters after six months. However, because of the limited amount of intra-oral donor bone, it is preferable to use decalcified freeze-dried bone allograft.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Froum, Sj" uniqKey="Froum S">SJ Froum</name></author><author><name sortKey="Ortiz, M" uniqKey="Ortiz M">M Ortiz</name></author><author><name sortKey="Witkin, Rt" uniqKey="Witkin R">RT Witkin</name></author><author><name sortKey="Thaler, R" uniqKey="Thaler R">R Thaler</name></author><author><name sortKey="Scopp, Iw" uniqKey="Scopp I">IW Scopp</name></author><author><name sortKey="Stahl, Ss" uniqKey="Stahl S">SS Stahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hawley, Ce" uniqKey="Hawley C">CE Hawley</name></author><author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiatt, Wh" uniqKey="Hiatt 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