Role of NBCe1 and AE2 in Secretory Ameloblasts
Identifieur interne : 005F61 ( Main/Merge ); précédent : 005F60; suivant : 005F62Role of NBCe1 and AE2 in Secretory Ameloblasts
Auteurs : Michael L. Paine [États-Unis] ; Malcolm L. Snead [États-Unis] ; Hongjun Wang [États-Unis] ; Natalia Abuladze ; Alexander Pushkin ; Weixin Liu ; Li Yo Kao ; Susan M. Wall [États-Unis] ; Young-Hee Kim [États-Unis] ; Ira KurtzSource :
- Journal of dental research [ 0022-0345 ] ; 2008.
Abstract
The H+/base transport processes that control the pH of the microenvironment adjacent to ameloblasts are not currently well understood. Mice null for the AE2 anion exchanger have abnormal enamel. In addition, patients with mutations in the electrogenic sodium bicarbonate cotransporter NBCe1 and mice lacking NBCe1 have enamel abnormalities. These observations suggest that AE2 and NBCe1 play important roles in amelogenesis. The present study aimed to understand the roles of AE2 and NBC1 in ameloblasts. The data showed that NBCe1 is expressed at the basolateral membrane of secretory ameloblasts, whereas AE2 is expressed at the apical membrane. Transcripts for AE2a and NBCe1-B were detected in RNA isolated from cultured ameloblast-like LS8 cells. Our data are the first evidence that AE2 and NBCe1 are expressed in ameloblasts
Url:
PubMed: 18362326
PubMed Central: 2504252
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<front><div type="abstract" xml:lang="en"><p id="P1">The H<sup>+</sup>
/base transport processes that control the pH of the microenvironment adjacent to ameloblasts are not currently well understood. Mice null for the AE2 anion exchanger have abnormal enamel. In addition, patients with mutations in the electrogenic sodium bicarbonate cotransporter NBCe1 and mice lacking NBCe1 have enamel abnormalities. These observations suggest that AE2 and NBCe1 play important roles in amelogenesis. The present study aimed to understand the roles of AE2 and NBC1 in ameloblasts. The data showed that NBCe1 is expressed at the basolateral membrane of secretory ameloblasts, whereas AE2 is expressed at the apical membrane. Transcripts for AE2a and NBCe1-B were detected in RNA isolated from cultured ameloblast-like LS8 cells. Our data are the first evidence that AE2 and NBCe1 are expressed in ameloblasts <italic>in vivo</italic>
in a polarized fashion thereby providing a mechanism for ameloblast transcellular bicarbonate secretion in the process of enamel formation and maturation.</p>
</div>
</front>
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