EdenteV2, Main, Merge, bibRecord, 005F61

Role of NBCe1 and AE2 in Secretory Ameloblasts

Identifieur interne : 005F61 ( Main/Merge ); précédent : 005F60; suivant : 005F62

Role of NBCe1 and AE2 in Secretory Ameloblasts

Auteurs : Michael L. Paine [États-Unis] ; Malcolm L. Snead [États-Unis] ; Hongjun Wang [États-Unis] ; Natalia Abuladze ; Alexander Pushkin ; Weixin Liu ; Li Yo Kao ; Susan M. Wall [États-Unis] ; Young-Hee Kim [États-Unis] ; Ira Kurtz

Source :

Journal of dental research [ 0022-0345 ] ; 2008.

RBID : PMC:2504252

Abstract

The H⁺/base transport processes that control the pH of the microenvironment adjacent to ameloblasts are not currently well understood. Mice null for the AE2 anion exchanger have abnormal enamel. In addition, patients with mutations in the electrogenic sodium bicarbonate cotransporter NBCe1 and mice lacking NBCe1 have enamel abnormalities. These observations suggest that AE2 and NBCe1 play important roles in amelogenesis. The present study aimed to understand the roles of AE2 and NBC1 in ameloblasts. The data showed that NBCe1 is expressed at the basolateral membrane of secretory ameloblasts, whereas AE2 is expressed at the apical membrane. Transcripts for AE2a and NBCe1-B were detected in RNA isolated from cultured ameloblast-like LS8 cells. Our data are the first evidence that AE2 and NBCe1 are expressed in ameloblasts in vivo in a polarized fashion thereby providing a mechanism for ameloblast transcellular bicarbonate secretion in the process of enamel formation and maturation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504252

PubMed: 18362326
PubMed Central: 2504252

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 002081
to stream Pmc, to step Curation: 002081
to stream Pmc, to step Checkpoint: 002604
to stream Ncbi, to step Merge: 002101
to stream Ncbi, to step Curation: 002101
to stream Ncbi, to step Checkpoint: 002101

Links to Exploration step

PMC:2504252

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of NBCe1 and AE2 in Secretory Ameloblasts</title>
<author><name sortKey="Paine, Michael L" sort="Paine, Michael L" uniqKey="Paine M" first="Michael L." last="Paine">Michael L. Paine</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Snead, Malcolm L" sort="Snead, Malcolm L" uniqKey="Snead M" first="Malcolm L." last="Snead">Malcolm L. Snead</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Hongjun" sort="Wang, Hongjun" uniqKey="Wang H" first="Hongjun" last="Wang">Hongjun Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abuladze, Natalia" sort="Abuladze, Natalia" uniqKey="Abuladze N" first="Natalia" last="Abuladze">Natalia Abuladze</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pushkin, Alexander" sort="Pushkin, Alexander" uniqKey="Pushkin A" first="Alexander" last="Pushkin">Alexander Pushkin</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Liu, Weixin" sort="Liu, Weixin" uniqKey="Liu W" first="Weixin" last="Liu">Weixin Liu</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kao, Li Yo" sort="Kao, Li Yo" uniqKey="Kao L" first="Li Yo" last="Kao">Li Yo Kao</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wall, Susan M" sort="Wall, Susan M" uniqKey="Wall S" first="Susan M." last="Wall">Susan M. Wall</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Medicine, Emory University, 1639 Pierce Dr. Atlanta GA 30322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea> Department of Medicine, Emory University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Young Hee" sort="Kim, Young Hee" uniqKey="Kim Y" first="Young-Hee" last="Kim">Young-Hee Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Medicine, Emory University, 1639 Pierce Dr. Atlanta GA 30322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea> Department of Medicine, Emory University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kurtz, Ira" sort="Kurtz, Ira" uniqKey="Kurtz I" first="Ira" last="Kurtz">Ira Kurtz</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18362326</idno>
<idno type="pmc">2504252</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504252</idno>
<idno type="RBID">PMC:2504252</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">002081</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002081</idno>
<idno type="wicri:Area/Pmc/Curation">002081</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002081</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002604</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002604</idno>
<idno type="wicri:Area/Ncbi/Merge">002101</idno>
<idno type="wicri:Area/Ncbi/Curation">002101</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002101</idno>
<idno type="wicri:doubleKey">0022-0345:2008:Paine M:role:of:nbce</idno>
<idno type="wicri:Area/Main/Merge">005F61</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of NBCe1 and AE2 in Secretory Ameloblasts</title>
<author><name sortKey="Paine, Michael L" sort="Paine, Michael L" uniqKey="Paine M" first="Michael L." last="Paine">Michael L. Paine</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Snead, Malcolm L" sort="Snead, Malcolm L" uniqKey="Snead M" first="Malcolm L." last="Snead">Malcolm L. Snead</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Hongjun" sort="Wang, Hongjun" uniqKey="Wang H" first="Hongjun" last="Wang">Hongjun Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles, California 90033</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, CSA Room 103, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Abuladze, Natalia" sort="Abuladze, Natalia" uniqKey="Abuladze N" first="Natalia" last="Abuladze">Natalia Abuladze</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pushkin, Alexander" sort="Pushkin, Alexander" uniqKey="Pushkin A" first="Alexander" last="Pushkin">Alexander Pushkin</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Liu, Weixin" sort="Liu, Weixin" uniqKey="Liu W" first="Weixin" last="Liu">Weixin Liu</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kao, Li Yo" sort="Kao, Li Yo" uniqKey="Kao L" first="Li Yo" last="Kao">Li Yo Kao</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wall, Susan M" sort="Wall, Susan M" uniqKey="Wall S" first="Susan M." last="Wall">Susan M. Wall</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Medicine, Emory University, 1639 Pierce Dr. Atlanta GA 30322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea> Department of Medicine, Emory University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Young Hee" sort="Kim, Young Hee" uniqKey="Kim Y" first="Young-Hee" last="Kim">Young-Hee Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Medicine, Emory University, 1639 Pierce Dr. Atlanta GA 30322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea> Department of Medicine, Emory University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kurtz, Ira" sort="Kurtz, Ira" uniqKey="Kurtz I" first="Ira" last="Kurtz">Ira Kurtz</name>
<affiliation><nlm:aff id="A2"> David Geffen School Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, California, 90095</nlm:aff>
<wicri:noCountry code="subfield">90095</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of dental research</title>
<idno type="ISSN">0022-0345</idno>
<idno type="eISSN">1544-0591</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The H<sup>+</sup>
/base transport processes that control the pH of the microenvironment adjacent to ameloblasts are not currently well understood. Mice null for the AE2 anion exchanger have abnormal enamel. In addition, patients with mutations in the electrogenic sodium bicarbonate cotransporter NBCe1 and mice lacking NBCe1 have enamel abnormalities. These observations suggest that AE2 and NBCe1 play important roles in amelogenesis. The present study aimed to understand the roles of AE2 and NBC1 in ameloblasts. The data showed that NBCe1 is expressed at the basolateral membrane of secretory ameloblasts, whereas AE2 is expressed at the apical membrane. Transcripts for AE2a and NBCe1-B were detected in RNA isolated from cultured ameloblast-like LS8 cells. Our data are the first evidence that AE2 and NBCe1 are expressed in ameloblasts <italic>in vivo</italic>
 in a polarized fashion thereby providing a mechanism for ameloblast transcellular bicarbonate secretion in the process of enamel formation and maturation.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F61 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005F61 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:2504252
   |texte=   Role of NBCe1 and AE2 in Secretory Ameloblasts
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:18362326" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a EdenteV2

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le patient édenté

Role of NBCe1 and AE2 in Secretory Ameloblasts

Role of NBCe1 and AE2 in Secretory Ameloblasts

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki