Efficacy of a chairside diagnostic test kit for estimation of C-reactive protein levels in periodontal disease
Identifieur interne : 004D72 ( Main/Merge ); précédent : 004D71; suivant : 004D73Efficacy of a chairside diagnostic test kit for estimation of C-reactive protein levels in periodontal disease
Auteurs : Girish Nagarale ; S. Ravindra ; Srinath Thakur ; Swati SettySource :
- Journal of Indian Society of Periodontology [ 0972-124X ] ; 2010.
Abstract
C-reactive protein [CRP] levels increase to hundreds of mg/mL within hours following infection. Studies have shown that serum CRP levels were elevated in periodontal disease. However, in all the previous studies, CRP levels were measured by using high-sensitivity CRP assay kits with minimal detection limits of 0.1 to 3 mg/L, which was much below the normal value of 10 mg/L. These high-sensitivity CRP assays need a proper laboratory setup, and these methods cannot be used as a routine chair-side test in the dental office.
The purpose of this study was to investigate the serum CRP levels in subjects with periodontal disease by using a rapid chair-side diagnostic test kit with a lower detection limit of 6 mg/L and to compare the CRP levels before and after periodontal therapy.
A total of 45 systemically healthy subjects were selected for the study. Subjects were divided into three groups: group A: healthy controls, group B: gingivitis, group C: periodontitis. Serum levels of CRP were determined by using a latex slide agglutination method with commercially available kit with lower detection limit of 6 mg/L.
CRP was negative in all the 15 subjects in groups A and B at baseline, 7th and 30th day. CRP was positive only in 2 subjects in Group C at baseline and 7th day.
Estimation of serum CRP by using a rapid chair-side diagnostic test kit is not of any significance in subjects with periodontitis.
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DOI: 10.4103/0972-124X.76919
PubMed: 21731244
PubMed Central: 3118069
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of a chairside diagnostic test kit for estimation of C-reactive protein levels in periodontal disease</title><author><name sortKey="Nagarale, Girish" sort="Nagarale, Girish" uniqKey="Nagarale G" first="Girish" last="Nagarale">Girish Nagarale</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ravindra, S" sort="Ravindra, S" uniqKey="Ravindra S" first="S." last="Ravindra">S. Ravindra</name><affiliation><nlm:aff id="aff2"><italic>Department of Periodontics, Hassanamba Dental College, Hassan, Karnataka, India</italic></nlm:aff></affiliation></author><author><name sortKey="Thakur, Srinath" sort="Thakur, Srinath" uniqKey="Thakur S" first="Srinath" last="Thakur">Srinath Thakur</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Setty, Swati" sort="Setty, Swati" uniqKey="Setty S" first="Swati" last="Setty">Swati Setty</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21731244</idno><idno type="pmc">3118069</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118069</idno><idno type="RBID">PMC:3118069</idno><idno type="doi">10.4103/0972-124X.76919</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">003184</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003184</idno><idno type="wicri:Area/Pmc/Curation">003184</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003184</idno><idno type="wicri:Area/Pmc/Checkpoint">002406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002406</idno><idno type="wicri:Area/Ncbi/Merge">003750</idno><idno type="wicri:Area/Ncbi/Curation">003750</idno><idno type="wicri:Area/Ncbi/Checkpoint">003750</idno><idno type="wicri:doubleKey">0972-124X:2010:Nagarale G:efficacy:of:a</idno><idno type="wicri:Area/Main/Merge">004D72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of a chairside diagnostic test kit for estimation of C-reactive protein levels in periodontal disease</title><author><name sortKey="Nagarale, Girish" sort="Nagarale, Girish" uniqKey="Nagarale G" first="Girish" last="Nagarale">Girish Nagarale</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ravindra, S" sort="Ravindra, S" uniqKey="Ravindra S" first="S." last="Ravindra">S. Ravindra</name><affiliation><nlm:aff id="aff2"><italic>Department of Periodontics, Hassanamba Dental College, Hassan, Karnataka, India</italic></nlm:aff></affiliation></author><author><name sortKey="Thakur, Srinath" sort="Thakur, Srinath" uniqKey="Thakur S" first="Srinath" last="Thakur">Srinath Thakur</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Setty, Swati" sort="Setty, Swati" uniqKey="Setty S" first="Swati" last="Setty">Swati Setty</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Indian Society of Periodontology</title><idno type="ISSN">0972-124X</idno><idno type="eISSN">0975-1580</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>C-reactive protein [CRP] levels increase to hundreds of mg/mL within hours following infection. Studies have shown that serum CRP levels were elevated in periodontal disease. However, in all the previous studies, CRP levels were measured by using high-sensitivity CRP assay kits with minimal detection limits of 0.1 to 3 mg/L, which was much below the normal value of 10 mg/L. These high-sensitivity CRP assays need a proper laboratory setup, and these methods cannot be used as a routine chair-side test in the dental office.</p></sec><sec id="st2"><title>Aim:</title><p>The purpose of this study was to investigate the serum CRP levels in subjects with periodontal disease by using a rapid chair-side diagnostic test kit with a lower detection limit of 6 mg/L and to compare the CRP levels before and after periodontal therapy.</p></sec><sec id="st3"><title>Materials and Methods:</title><p>A total of 45 systemically healthy subjects were selected for the study. Subjects were divided into three groups: group A: healthy controls, group B: gingivitis, group C: periodontitis. Serum levels of CRP were determined by using a latex slide agglutination method with commercially available kit with lower detection limit of 6 mg/L.</p></sec><sec id="st4"><title>Results:</title><p>CRP was negative in all the 15 subjects in groups A and B at baseline, 7th and 30th day. CRP was positive only in 2 subjects in Group C at baseline and 7th day.</p></sec><sec id="st5"><title>Conclusion:</title><p>Estimation of serum CRP by using a rapid chair-side diagnostic test kit is not of any significance in subjects with periodontitis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ebersole, Jl" uniqKey="Ebersole J">JL Ebersole</name></author><author><name sortKey="Cappelli, D" uniqKey="Cappelli D">D Cappelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morey, Jj" uniqKey="Morey J">JJ Morey</name></author><author><name sortKey="Kushner, I" uniqKey="Kushner I">I Kushner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabay, C" uniqKey="Gabay C">C Gabay</name></author><author><name sortKey="Kushner, I" uniqKey="Kushner I">I Kushner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shine, B" 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