An Oligodeoxynucleotide with Promising Modulation Activity for the Proliferation and Activation of Osteoblast
Identifieur interne : 004337 ( Main/Merge ); précédent : 004336; suivant : 004338An Oligodeoxynucleotide with Promising Modulation Activity for the Proliferation and Activation of Osteoblast
Auteurs : Zhiyuan Feng ; Yuqin Shen ; Liying Wang ; Lin Cheng ; Jing Wang ; Quanshun Li ; Wei Shi ; Xinhua SunSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2011.
Abstract
The paper explored the regulatory role of oligodeoxynucleotides (ODNs) with specific sequences in the proliferation and activation of osteoblast, using human osteoblast-like cell line MG 63 as the model. Through the administration of ODNs to MG 63 cells at a concentration of 1.0 μg/mL, ODN MT01 with positive effects on proliferation and activation of osteoblast was selected from 11 different ODNs by methyl thiazolyl tetrazolium (MTT) assay and alkaline phosphatase (ALP) activity measurement. To get a deeper insight into the molecular mechanism, effects of ODN MT01 treatment on the expression level of Sp7, runx-2, collagen-I, osteoprotegerin (OPG) and RANK ligand (RANKL) were determined using quantitative real time PCR and Western blotting. Remarkably, the mRNA and protein expression levels of Sp7, runx-2, collagen-I and OPG were improved after ODN MT01 treatment. Meanwhile, the protein expression level of RANKL was dramatically decreased. These results suggested that ODN MT01 had a significant impact in facilitating osteogenic proliferation and activation, and provided a direct evidence for the notion that single strand ODN could regulate the balance of bone formation and resorption, and thus was of great potential in the rebuilding of alveolar bone.
Url:
DOI: 10.3390/ijms12042543
PubMed: 21731457
PubMed Central: 3127133
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PMC:3127133Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Oligodeoxynucleotide with Promising Modulation Activity for the Proliferation and Activation of Osteoblast</title><author><name sortKey="Feng, Zhiyuan" sort="Feng, Zhiyuan" uniqKey="Feng Z" first="Zhiyuan" last="Feng">Zhiyuan Feng</name><affiliation><nlm:aff id="af1-ijms-12-02543">Department of Orthodontics, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mails:<email>fzy00@sina.com</email> (Z.F.);<email>33817805@qq.com</email> (J.W.)</nlm:aff></affiliation></author><author><name sortKey="Shen, Yuqin" sort="Shen, Yuqin" uniqKey="Shen Y" first="Yuqin" last="Shen">Yuqin Shen</name><affiliation><nlm:aff id="af2-ijms-12-02543">Department of Periodontal, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mail:<email>shenyuqin326@sina.com</email></nlm:aff></affiliation></author><author><name sortKey="Wang, Liying" sort="Wang, Liying" uniqKey="Wang L" first="Liying" last="Wang">Liying Wang</name><affiliation><nlm:aff id="af3-ijms-12-02543">Department of Molecular Biology, College of Basic Medicine, Jilin University, Changchun 130021, China; E-Mail:<email>wlying@jlu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Cheng, Lin" sort="Cheng, Lin" uniqKey="Cheng L" first="Lin" last="Cheng">Lin Cheng</name><affiliation><nlm:aff id="af4-ijms-12-02543">Department of Oral Cavity, The Second Affiliated Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China; E-Mail:<email>chenglin6002@sina.com</email></nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="af1-ijms-12-02543">Department of Orthodontics, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mails:<email>fzy00@sina.com</email> (Z.F.);<email>33817805@qq.com</email> (J.W.)</nlm:aff></affiliation></author><author><name sortKey="Li, Quanshun" sort="Li, Quanshun" uniqKey="Li Q" first="Quanshun" last="Li">Quanshun Li</name><affiliation><nlm:aff id="af5-ijms-12-02543">Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, 2699 Qianjin Road, Changchun 130021, China; 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E-Mails:<email>fzy00@sina.com</email> (Z.F.);<email>33817805@qq.com</email> (J.W.)</nlm:aff></affiliation></author><author><name sortKey="Shen, Yuqin" sort="Shen, Yuqin" uniqKey="Shen Y" first="Yuqin" last="Shen">Yuqin Shen</name><affiliation><nlm:aff id="af2-ijms-12-02543">Department of Periodontal, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mail:<email>shenyuqin326@sina.com</email></nlm:aff></affiliation></author><author><name sortKey="Wang, Liying" sort="Wang, Liying" uniqKey="Wang L" first="Liying" last="Wang">Liying Wang</name><affiliation><nlm:aff id="af3-ijms-12-02543">Department of Molecular Biology, College of Basic Medicine, Jilin University, Changchun 130021, China; E-Mail:<email>wlying@jlu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Cheng, Lin" sort="Cheng, Lin" uniqKey="Cheng L" first="Lin" last="Cheng">Lin Cheng</name><affiliation><nlm:aff id="af4-ijms-12-02543">Department of Oral Cavity, The Second Affiliated Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China; E-Mail:<email>chenglin6002@sina.com</email></nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="af1-ijms-12-02543">Department of Orthodontics, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mails:<email>fzy00@sina.com</email> (Z.F.);<email>33817805@qq.com</email> (J.W.)</nlm:aff></affiliation></author><author><name sortKey="Li, Quanshun" sort="Li, Quanshun" uniqKey="Li Q" first="Quanshun" last="Li">Quanshun Li</name><affiliation><nlm:aff id="af5-ijms-12-02543">Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, 2699 Qianjin Road, Changchun 130021, China; E-Mail:<email>quanshun@jlu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name><affiliation><nlm:aff id="af5-ijms-12-02543">Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, 2699 Qianjin Road, Changchun 130021, China; E-Mail:<email>quanshun@jlu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Sun, Xinhua" sort="Sun, Xinhua" uniqKey="Sun X" first="Xinhua" last="Sun">Xinhua Sun</name><affiliation><nlm:aff id="af1-ijms-12-02543">Department of Orthodontics, School of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, China; E-Mails:<email>fzy00@sina.com</email> (Z.F.);<email>33817805@qq.com</email> (J.W.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The paper explored the regulatory role of oligodeoxynucleotides (ODNs) with specific sequences in the proliferation and activation of osteoblast, using human osteoblast-like cell line MG 63 as the model. Through the administration of ODNs to MG 63 cells at a concentration of 1.0 μg/mL, ODN MT01 with positive effects on proliferation and activation of osteoblast was selected from 11 different ODNs by methyl thiazolyl tetrazolium (MTT) assay and alkaline phosphatase (ALP) activity measurement. To get a deeper insight into the molecular mechanism, effects of ODN MT01 treatment on the expression level of Sp7, runx-2, collagen-I, osteoprotegerin (OPG) and RANK ligand (RANKL) were determined using quantitative real time PCR and Western blotting. Remarkably, the mRNA and protein expression levels of Sp7, runx-2, collagen-I and OPG were improved after ODN MT01 treatment. Meanwhile, the protein expression level of RANKL was dramatically decreased. These results suggested that ODN MT01 had a significant impact in facilitating osteogenic proliferation and activation, and provided a direct evidence for the notion that single strand ODN could regulate the balance of bone formation and resorption, and thus was of great potential in the rebuilding of alveolar bone.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Verna, C" uniqKey="Verna C">C Verna</name></author><author><name sortKey="Zaffe, D" uniqKey="Zaffe D">D Zaffe</name></author><author><name sortKey="Siciliani, G" uniqKey="Siciliani G">G Siciliani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graves, Dt" uniqKey="Graves D">DT Graves</name></author><author><name sortKey="Kayal, Ra" uniqKey="Kayal R">RA Kayal</name></author><author><name sortKey="Oates, T" uniqKey="Oates T">T Oates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ducy, P" uniqKey="Ducy 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