Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study
Identifieur interne : 003466 ( Main/Merge ); précédent : 003465; suivant : 003467Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study
Auteurs : Fahed Samir Habash ; Ra D O Abu Hantash ; Mohammed Abu YunisSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2012.
Abstract
This study was carried out to assess the innervation patterns in oral cancer using the general neuronal marker protein gene product 9.5 (PGP 9.5) and to find an explanation for why oral cancer tends to be painless in the early stages.
Tumor tissue from 30 unselected patients with oral squamous cell carcinoma was evaluated for this study. PGP 9.5 was used to localize nerve fibers in oral squamous cell carcinoma. An indirect immunofluorescence technique using biotin/FITC streptavidin detection system was used on paraffin wax sections of tumor tissue fixed in neutral buffered formalin.
There was no PGP9.5 immunoreactivity in the normal tissue adjacent to the tumor in 18 cases out of 30 (60%). In 12/30 of oral squamous cell carcinoma, preexisting nerve fibers were detected in tissue stroma adjacent to the cancer tissue. Labeled nerve fibers between tumor cells were detected only in 2 out of the 30 cases.
There are no apparent patterns of innervations in the cancer tissues themselves, but there are innervations patterns in the surrounding tissue, which presumably represents preexisting nerves. These results may partly explain why oral cancer tends to be painless in the early stages.
Url:
DOI: 10.4103/0973-029X.92967
PubMed: 22434940
PubMed Central: 3303516
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study</title><author><name sortKey="Habash, Fahed Samir" sort="Habash, Fahed Samir" uniqKey="Habash F" first="Fahed Samir" last="Habash">Fahed Samir Habash</name><affiliation><nlm:aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Hantash, Ra D O Abu" sort="Hantash, Ra D O Abu" uniqKey="Hantash R" first="Ra D O Abu" last="Hantash">Ra D O Abu Hantash</name><affiliation><nlm:aff id="aff2">Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Yunis, Mohammed Abu" sort="Yunis, Mohammed Abu" uniqKey="Yunis M" first="Mohammed Abu" last="Yunis">Mohammed Abu Yunis</name><affiliation><nlm:aff id="aff3">Dean of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22434940</idno><idno type="pmc">3303516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303516</idno><idno type="RBID">PMC:3303516</idno><idno type="doi">10.4103/0973-029X.92967</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003251</idno><idno type="wicri:Area/Pmc/Curation">003251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003251</idno><idno type="wicri:Area/Pmc/Checkpoint">001F82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F82</idno><idno type="wicri:Area/Ncbi/Merge">003C83</idno><idno type="wicri:Area/Ncbi/Curation">003C83</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C83</idno><idno type="wicri:doubleKey">0973-029X:2012:Habash F:assessment:of:the</idno><idno type="wicri:Area/Main/Merge">003466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study</title><author><name sortKey="Habash, Fahed Samir" sort="Habash, Fahed Samir" uniqKey="Habash F" first="Fahed Samir" last="Habash">Fahed Samir Habash</name><affiliation><nlm:aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Hantash, Ra D O Abu" sort="Hantash, Ra D O Abu" uniqKey="Hantash R" first="Ra D O Abu" last="Hantash">Ra D O Abu Hantash</name><affiliation><nlm:aff id="aff2">Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Yunis, Mohammed Abu" sort="Yunis, Mohammed Abu" uniqKey="Yunis M" first="Mohammed Abu" last="Yunis">Mohammed Abu Yunis</name><affiliation><nlm:aff id="aff3">Dean of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>This study was carried out to assess the innervation patterns in oral cancer using the general neuronal marker protein gene product 9.5 (PGP 9.5) and to find an explanation for why oral cancer tends to be painless in the early stages.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Tumor tissue from 30 unselected patients with oral squamous cell carcinoma was evaluated for this study. PGP 9.5 was used to localize nerve fibers in oral squamous cell carcinoma. An indirect immunofluorescence technique using biotin/FITC streptavidin detection system was used on paraffin wax sections of tumor tissue fixed in neutral buffered formalin.</p></sec><sec id="st3"><title>Results:</title><p>There was no PGP9.5 immunoreactivity in the normal tissue adjacent to the tumor in 18 cases out of 30 (60%). In 12/30 of oral squamous cell carcinoma, preexisting nerve fibers were detected in tissue stroma adjacent to the cancer tissue. Labeled nerve fibers between tumor cells were detected only in 2 out of the 30 cases.</p></sec><sec id="st4"><title>Conclusion:</title><p>There are no apparent patterns of innervations in the cancer tissues themselves, but there are innervations patterns in the surrounding tissue, which presumably represents preexisting nerves. 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