Novel Biomarkers of Periodontitis and/or Obesity in Saliva – An Exploratory Analysis
Identifieur interne : 000F17 ( Main/Merge ); précédent : 000F16; suivant : 000F18Novel Biomarkers of Periodontitis and/or Obesity in Saliva – An Exploratory Analysis
Auteurs : Erica N. Recker [États-Unis] ; Kim A. Brogden [États-Unis] ; Gustavo Avila-Ortiz [États-Unis] ; Carol L. Fischer [États-Unis] ; Keyla Pagan-Rivera [États-Unis] ; Deborah V. Dawson [États-Unis] ; Katherine M. Smith [États-Unis] ; Satheesh Elangovan [États-Unis]Source :
- Archives of oral biology [ 0003-9969 ] ; 2015.
Abstract
Recent studies point to the clinical and research utility of saliva as a valuable diagnostic aid for monitoring periodontal health. The objectives of this study were to detect novel biomarkers attributed to chronic inflammation in saliva and to determine if the levels of these markers correlate with severity of periodontitis and with standard obesity measures in participants in a periodontal maintenance program.
In this cross-sectional assessment of 63 participants, unstimulated whole saliva was collected after recording anthropometric and clinical parameters of obesity and periodontitis, respectively. The levels of interleukin-1 receptor antagonist (IL-1ra), sCD40L, granzyme B and alpha-fetoprotein (AFP) in saliva were determined using multiplex proteomic immunoassays. The correlation between the four tested biomarker concentrations and obesity/periodontal measures was determined.
Positive correlation between fat% and granzyme B levels (r=0.292; p=0.020) and negative correlation between BMI and sCD40L (r=0.256;p=0.043) was observed. In addition, positive correlation between severity of periodontal disease and levels of IL1-ra (r=0.253; p=0.046) and negative correlation between periodontitis severity and sCD40L salivary levels (r=0.272; p=0.031) was noted. None of the above correlations remained statistically significant after multiple comparisons adjustment. After adjustment for clinical covariates, the relationship between sCD40L and periodontal severity remained suggestive (p=0.081).
Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program. Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers.
Url:
DOI: 10.1016/j.archoralbio.2015.07.006
PubMed: 26263539
PubMed Central: 4567926
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Recker</name><affiliation wicri:level="2"><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Brogden, Kim A" sort="Brogden, Kim A" uniqKey="Brogden K" first="Kim A." last="Brogden">Kim A. Brogden</name><affiliation wicri:level="2"><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Periodontics, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Avila Ortiz, Gustavo" sort="Avila Ortiz, Gustavo" uniqKey="Avila Ortiz G" first="Gustavo" last="Avila-Ortiz">Gustavo Avila-Ortiz</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Periodontics, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Fischer, Carol L" sort="Fischer, Carol L" uniqKey="Fischer C" first="Carol L." last="Fischer">Carol L. Fischer</name><affiliation wicri:level="2"><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Pagan Rivera, Keyla" sort="Pagan Rivera, Keyla" uniqKey="Pagan Rivera K" first="Keyla" last="Pagan-Rivera">Keyla Pagan-Rivera</name><affiliation wicri:level="2"><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Biostatistics, University of Iowa College of Public Health, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Dawson, Deborah V" sort="Dawson, Deborah V" uniqKey="Dawson D" first="Deborah V." last="Dawson">Deborah V. Dawson</name><affiliation wicri:level="2"><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Katherine M" sort="Smith, Katherine M" uniqKey="Smith K" first="Katherine M." last="Smith">Katherine M. Smith</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Periodontics, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Periodontics, University of Iowa College of Dentistry, Iowa City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Archives of oral biology</title><idno type="ISSN">0003-9969</idno><idno type="eISSN">1879-1506</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Recent studies point to the clinical and research utility of saliva as a valuable diagnostic aid for monitoring periodontal health. The objectives of this study were to detect novel biomarkers attributed to chronic inflammation in saliva and to determine if the levels of these markers correlate with severity of periodontitis and with standard obesity measures in participants in a periodontal maintenance program.</p></sec><sec id="S2"><title>Design</title><p id="P2">In this cross-sectional assessment of 63 participants, unstimulated whole saliva was collected after recording anthropometric and clinical parameters of obesity and periodontitis, respectively. The levels of interleukin-1 receptor antagonist (IL-1ra), sCD40L, granzyme B and alpha-fetoprotein (AFP) in saliva were determined using multiplex proteomic immunoassays. The correlation between the four tested biomarker concentrations and obesity/periodontal measures was determined.</p></sec><sec id="S3"><title>Results</title><p id="P3">Positive correlation between fat% and granzyme B levels (r=0.292; p=0.020) and negative correlation between BMI and sCD40L (r=0.256;p=0.043) was observed. In addition, positive correlation between severity of periodontal disease and levels of IL1-ra (r=0.253; p=0.046) and negative correlation between periodontitis severity and sCD40L salivary levels (r=0.272; p=0.031) was noted. None of the above correlations remained statistically significant after multiple comparisons adjustment. After adjustment for clinical covariates, the relationship between sCD40L and periodontal severity remained suggestive (p=0.081).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program. Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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