Total tooth loss and prevalent cardiovascular disease in men and women. Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
Identifieur interne : 008095 ( Main/Exploration ); précédent : 008094; suivant : 008096Total tooth loss and prevalent cardiovascular disease in men and women. Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
Auteurs : Gordon Lowe [Royaume-Uni] ; Mark Woodward [Australie] ; Ann Rumley [Royaume-Uni] ; Caroline Morrison [Royaume-Uni] ; Hugh Tunstall-Pedoe [Royaume-Uni] ; Kenneth Stephen [Royaume-Uni]Source :
- Journal of clinical epidemiology [ 0895-4356 ] ; 2003.
Descripteurs français
- KwdFr :
- Acide ascorbique (sang), Adulte, Adulte d'âge moyen, Bouche édentée (), Bouche édentée (sang), Bouche édentée (épidémiologie), Citrus, Enquêtes de santé, Facteurs de risque, Femelle, Humains, Maladies cardiovasculaires (sang), Maladies cardiovasculaires (épidémiologie), Maladies cardiovasculaires (étiologie), Mâle, Perte dentaire (), Perte dentaire (sang), Perte dentaire (épidémiologie), Prévalence, Régime alimentaire (effets indésirables), Répartition par sexe, Répartition par âge, Sujet âgé, Écosse (épidémiologie).
- MESH :
- effets indésirables : Régime alimentaire.
- sang : Acide ascorbique, Bouche édentée, Maladies cardiovasculaires, Perte dentaire.
- épidémiologie : Bouche édentée, Maladies cardiovasculaires, Perte dentaire, Écosse.
- étiologie : Maladies cardiovasculaires.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Agrume, Acide ascorbique, Bouche édentée, Citrus, Consommation alimentaire, Appareil circulatoire pathologie, Enquêtes de santé, Facteurs de risque, Femelle, Humains, Inflammation, Dent, Mâle, Perte, Perte dentaire, Prévalence, Répartition par sexe, Répartition par âge, Sujet âgé, Taux concentration, Plasma sanguin, Thrombose, Facteur risque, Sexe, Homme.
- Wicri :
- topic : Agrume, Consommation alimentaire, Homme.
English descriptors
- KwdEn :
- Adult, Age Distribution, Aged, Ascorbic Acid (blood), Ascorbic acid, Blood plasma, Cardiovascular Diseases (blood), Cardiovascular Diseases (epidemiology), Cardiovascular Diseases (etiology), Cardiovascular disease, Citrus, Citrus fruit, Concentration factor, Diet (adverse effects), Female, Food intake, Health Surveys, Human, Humans, Inflammation, Loss, Male, Middle Aged, Mouth, Edentulous (blood), Mouth, Edentulous (complications), Mouth, Edentulous (epidemiology), Prevalence, Risk Factors, Risk factor, Scotland (epidemiology), Sex, Sex Distribution, Thrombosis, Tooth, Tooth Loss (blood), Tooth Loss (complications), Tooth Loss (epidemiology).
- MESH :
- chemical , blood : Ascorbic Acid.
- geographic , epidemiology : Scotland.
- adverse effects : Diet.
- blood : Cardiovascular Diseases, Mouth, Edentulous, Tooth Loss.
- complications : Mouth, Edentulous, Tooth Loss.
- epidemiology : Cardiovascular Diseases, Mouth, Edentulous, Tooth Loss.
- etiology : Cardiovascular Diseases.
- Adult, Age Distribution, Aged, Citrus, Female, Health Surveys, Humans, Male, Middle Aged, Prevalence, Risk Factors, Sex Distribution.
Abstract
Background and Objective: Tooth loss has been associated with cardiovascular disease (CVD), but the mechanisms are unclear. We evaluated the association of total tooth loss with prevalent CVD in men and women; as well as with citrus fruit consumption, plasma vitamin C, and inflammatory and thrombotic variables. Methods: We used an age-and sex-stratified population survey, of men and women aged 25-74 years, in North Glasgow. Results: Thirty-eight percent of women and 29% of men were edentulous. Total tooth loss was associated with prevalent CVD in both sexes. After adjustment for major potential confounders (age, sex, smoking, and social class), the odds ratio (95% CI) for prevalent CVD was 1.55 (1.13, 2.13) in the edentulous. Total tooth loss was also associated with low citrus fruit consumption and low plasma vitamin C levels, increased plasma C-reactive protein in men, and with increased plasma interleukin-6, fibrinogen, and factor VIII levels in women. Conclusion: Prevalent CVD is associated with total tooth loss. Possible mechanisms include low intake of citrus fruit, and hence, low plasma vitamin C levels, and a predisposition to low-grade inflammation and thrombosis. It may be prudent to ensure adequate vitamin C intake in people with no teeth.
Affiliations:
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Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables</title><author><name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute for International Health, University of Sydney, 144 Burren Street</s1><s2>Newbourne, NSW 2042</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Newbourne, NSW 2042</wicri:noRegion></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Caroline" sort="Morrison, Caroline" uniqKey="Morrison C" first="Caroline" last="Morrison">Caroline Morrison</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>MONICA Project, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Tunstall Pedoe, Hugh" sort="Tunstall Pedoe, Hugh" uniqKey="Tunstall Pedoe H" first="Hugh" last="Tunstall-Pedoe">Hugh Tunstall-Pedoe</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital</s1><s2>Dundee D01 9SY</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Dundee D01 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Stephen, Kenneth" sort="Stephen, Kenneth" uniqKey="Stephen K" first="Kenneth" last="Stephen">Kenneth Stephen</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Dental Public Health Unit, Dental School, University of Glasgow, 378 Sauchiehall St.</s1><s2>Glasgow G2 3JZ</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow G2 3JZ</wicri:noRegion><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0016219</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 04-0016219 INIST</idno><idno type="RBID">Pascal:04-0016219</idno><idno type="wicri:Area/PascalFrancis/Corpus">000580</idno><idno type="wicri:Area/PascalFrancis/Curation">000123</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000571</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000571</idno><idno type="wicri:doubleKey">0895-4356:2003:Lowe G:total:tooth:loss</idno><idno type="wicri:Area/Main/Merge">008330</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:12921939</idno><idno type="wicri:Area/PubMed/Corpus">002E87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E87</idno><idno type="wicri:Area/PubMed/Curation">002E87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002E87</idno><idno type="wicri:Area/PubMed/Checkpoint">002E87</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E87</idno><idno type="wicri:Area/Ncbi/Merge">000D45</idno><idno type="wicri:Area/Ncbi/Curation">000D45</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D45</idno><idno type="wicri:doubleKey">0895-4356:2003:Lowe G:total:tooth:loss</idno><idno type="wicri:Area/Main/Merge">007D98</idno><idno type="wicri:Area/Main/Curation">008095</idno><idno type="wicri:Area/Main/Exploration">008095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Total tooth loss and prevalent cardiovascular disease in men and women. Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables</title><author><name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute for International Health, University of Sydney, 144 Burren Street</s1><s2>Newbourne, NSW 2042</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Newbourne, NSW 2042</wicri:noRegion></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Caroline" sort="Morrison, Caroline" uniqKey="Morrison C" first="Caroline" last="Morrison">Caroline Morrison</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>MONICA Project, Royal Infirmary, 10 Alexandra Parade</s1><s2>Glasgow, G31 2ER</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, G31 2ER</wicri:noRegion></affiliation></author><author><name sortKey="Tunstall Pedoe, Hugh" sort="Tunstall Pedoe, Hugh" uniqKey="Tunstall Pedoe H" first="Hugh" last="Tunstall-Pedoe">Hugh Tunstall-Pedoe</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital</s1><s2>Dundee D01 9SY</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Dundee D01 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Stephen, Kenneth" sort="Stephen, Kenneth" uniqKey="Stephen K" first="Kenneth" last="Stephen">Kenneth Stephen</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Dental Public Health Unit, Dental School, University of Glasgow, 378 Sauchiehall St.</s1><s2>Glasgow G2 3JZ</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow G2 3JZ</wicri:noRegion><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical epidemiology</title><title level="j" type="abbreviated">J. clin. epidemiol.</title><idno type="ISSN">0895-4356</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical epidemiology</title><title level="j" type="abbreviated">J. clin. epidemiol.</title><idno type="ISSN">0895-4356</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Ascorbic Acid (blood)</term><term>Ascorbic acid</term><term>Blood plasma</term><term>Cardiovascular Diseases (blood)</term><term>Cardiovascular Diseases (epidemiology)</term><term>Cardiovascular Diseases (etiology)</term><term>Cardiovascular disease</term><term>Citrus</term><term>Citrus fruit</term><term>Concentration factor</term><term>Diet (adverse effects)</term><term>Female</term><term>Food intake</term><term>Health Surveys</term><term>Human</term><term>Humans</term><term>Inflammation</term><term>Loss</term><term>Male</term><term>Middle Aged</term><term>Mouth, Edentulous (blood)</term><term>Mouth, Edentulous (complications)</term><term>Mouth, Edentulous (epidemiology)</term><term>Prevalence</term><term>Risk Factors</term><term>Risk factor</term><term>Scotland (epidemiology)</term><term>Sex</term><term>Sex Distribution</term><term>Thrombosis</term><term>Tooth</term><term>Tooth Loss (blood)</term><term>Tooth Loss (complications)</term><term>Tooth Loss (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide ascorbique (sang)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bouche édentée ()</term><term>Bouche édentée (sang)</term><term>Bouche édentée (épidémiologie)</term><term>Citrus</term><term>Enquêtes de santé</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Maladies cardiovasculaires (sang)</term><term>Maladies cardiovasculaires (épidémiologie)</term><term>Maladies cardiovasculaires (étiologie)</term><term>Mâle</term><term>Perte dentaire ()</term><term>Perte dentaire (sang)</term><term>Perte dentaire (épidémiologie)</term><term>Prévalence</term><term>Régime alimentaire (effets indésirables)</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Écosse (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ascorbic Acid</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Scotland</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cardiovascular Diseases</term><term>Mouth, Edentulous</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Mouth, Edentulous</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Régime alimentaire</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cardiovascular Diseases</term><term>Mouth, Edentulous</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide ascorbique</term><term>Bouche édentée</term><term>Maladies cardiovasculaires</term><term>Perte dentaire</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Bouche édentée</term><term>Maladies cardiovasculaires</term><term>Perte dentaire</term><term>Écosse</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies cardiovasculaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Citrus</term><term>Female</term><term>Health Surveys</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term><term>Sex Distribution</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agrume</term><term>Acide ascorbique</term><term>Bouche édentée</term><term>Citrus</term><term>Consommation alimentaire</term><term>Appareil circulatoire pathologie</term><term>Enquêtes de santé</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Inflammation</term><term>Dent</term><term>Mâle</term><term>Perte</term><term>Perte dentaire</term><term>Prévalence</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Taux concentration</term><term>Plasma sanguin</term><term>Thrombose</term><term>Facteur risque</term><term>Sexe</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Agrume</term><term>Consommation alimentaire</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and Objective: Tooth loss has been associated with cardiovascular disease (CVD), but the mechanisms are unclear. We evaluated the association of total tooth loss with prevalent CVD in men and women; as well as with citrus fruit consumption, plasma vitamin C, and inflammatory and thrombotic variables. Methods: We used an age-and sex-stratified population survey, of men and women aged 25-74 years, in North Glasgow. Results: Thirty-eight percent of women and 29% of men were edentulous. Total tooth loss was associated with prevalent CVD in both sexes. After adjustment for major potential confounders (age, sex, smoking, and social class), the odds ratio (95% CI) for prevalent CVD was 1.55 (1.13, 2.13) in the edentulous. Total tooth loss was also associated with low citrus fruit consumption and low plasma vitamin C levels, increased plasma C-reactive protein in men, and with increased plasma interleukin-6, fibrinogen, and factor VIII levels in women. Conclusion: Prevalent CVD is associated with total tooth loss. Possible mechanisms include low intake of citrus fruit, and hence, low plasma vitamin C levels, and a predisposition to low-grade inflammation and thrombosis. It may be prudent to ensure adequate vitamin C intake in people with no teeth.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Glasgow</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name></noRegion><name sortKey="Morrison, Caroline" sort="Morrison, Caroline" uniqKey="Morrison C" first="Caroline" last="Morrison">Caroline Morrison</name><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><name sortKey="Stephen, Kenneth" sort="Stephen, Kenneth" uniqKey="Stephen K" first="Kenneth" last="Stephen">Kenneth Stephen</name><name sortKey="Tunstall Pedoe, Hugh" sort="Tunstall Pedoe, Hugh" uniqKey="Tunstall Pedoe H" first="Hugh" last="Tunstall-Pedoe">Hugh Tunstall-Pedoe</name></country><country name="Australie"><noRegion><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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