Short-term Teriparatide Delivery and Osseointegration: a Clinical Feasibility Study
Identifieur interne : 004A47 ( Main/Exploration ); précédent : 004A46; suivant : 004A48Short-term Teriparatide Delivery and Osseointegration: a Clinical Feasibility Study
Auteurs : U. Kuchler [Autriche] ; E. R. Luvizuto [Autriche] ; S. Tangl [Autriche] ; G. Watzek [Autriche] ; R. Gruber [Autriche]Source :
- Journal of dental research [ 0022-0345 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on the osseointegration of titanium implants have not been performed. We conducted an open-label randomized controlled feasibility study and included 24 individuals with edentulous lower jaws. The participants received 2 study implants in the mandible during interforaminal dental implant surgery. They were randomly assigned to receive either 20 μg of teriparatide once daily for 28 days or no treatment. Study implants were retrieved from 23 participants after 9 weeks and were subjected to histomorphometric analyses. Endpoints were new bone-volume-per-tissue-volume (NBV/TV) and new bone-to-implant-contact (NBIC). We report here that median values of NBV/TV in the control and the teriparatide groups were 15.4% vs. 17.6% in the periosteal compartment, 11.3% vs. 16.5% in the cortical compartment, and 7.3% vs. 12.0% in the medullary compartment, respectively. NBIC median values in the control and the teriparatide groups were 3.3% vs. 4.1% in the periosteal compartment, 5.0% vs. 4.4% in the cortical compartment, and 0.3% vs. 1.4% in the medullary compartment, respectively. The results provide the first histological data on the osseointegration of titanium study implants in individuals treated with teriparatide. ClinicalTrials.gov number, NCT00089674. Abbreviations: NBV/ TV, new bone-volume per tissue volume; NBIC, new bone-to-implant contact; BV/TV, bone-volume per tissue volume; BIC, bone-to-implant contact; ROI, region of interest.
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Tangl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Oral Surgery, Medical University of Vienna, Sensengasse 2a</s1><s2>1090 Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Austrian Cluster for Tissue Regeneration</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Austrian Cluster for Tissue Regeneration</wicri:noRegion></affiliation></author><author><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G." last="Watzek">G. Watzek</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Oral Surgery, Medical University of Vienna, Sensengasse 2a</s1><s2>1090 Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Austrian Cluster for Tissue Regeneration</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Austrian Cluster for Tissue Regeneration</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R." last="Gruber">R. Gruber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Oral Surgery, Medical University of Vienna, Sensengasse 2a</s1><s2>1090 Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Austrian Cluster for Tissue Regeneration</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Austrian Cluster for Tissue Regeneration</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of dental research</title><title level="j" type="abbreviated">J. dent. res.</title><idno type="ISSN">0022-0345</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of dental research</title><title level="j" type="abbreviated">J. dent. res.</title><idno type="ISSN">0022-0345</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiosteoporotic</term><term>Biological activity</term><term>Controlled therapeutic trial</term><term>Dental implant</term><term>Dentistry</term><term>Human</term><term>Osteointegration</term><term>Parathyroid hormone</term><term>Randomization</term><term>Short term</term><term>Teriparatide</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tériparatide</term><term>Court terme</term><term>Activité biologique</term><term>Ostéointégration</term><term>Homme</term><term>Randomisation</term><term>Hormone parathyroïde</term><term>Dentisterie</term><term>Essai thérapeutique contrôlé</term><term>Antiostéoporotique</term><term>Traitement</term><term>Implant dentaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on the osseointegration of titanium implants have not been performed. We conducted an open-label randomized controlled feasibility study and included 24 individuals with edentulous lower jaws. The participants received 2 study implants in the mandible during interforaminal dental implant surgery. They were randomly assigned to receive either 20 μg of teriparatide once daily for 28 days or no treatment. Study implants were retrieved from 23 participants after 9 weeks and were subjected to histomorphometric analyses. Endpoints were new bone-volume-per-tissue-volume (NBV/TV) and new bone-to-implant-contact (NBIC). We report here that median values of NBV/TV in the control and the teriparatide groups were 15.4% vs. 17.6% in the periosteal compartment, 11.3% vs. 16.5% in the cortical compartment, and 7.3% vs. 12.0% in the medullary compartment, respectively. NBIC median values in the control and the teriparatide groups were 3.3% vs. 4.1% in the periosteal compartment, 5.0% vs. 4.4% in the cortical compartment, and 0.3% vs. 1.4% in the medullary compartment, respectively. The results provide the first histological data on the osseointegration of titanium study implants in individuals treated with teriparatide. ClinicalTrials.gov number, NCT00089674. Abbreviations: NBV/ TV, new bone-volume per tissue volume; NBIC, new bone-to-implant contact; BV/TV, bone-volume per tissue volume; BIC, bone-to-implant contact; ROI, region of interest.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Kuchler, U" sort="Kuchler, U" uniqKey="Kuchler U" first="U." last="Kuchler">U. Kuchler</name></region><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R." last="Gruber">R. Gruber</name><name sortKey="Gruber, R" sort="Gruber, R" uniqKey="Gruber R" first="R." last="Gruber">R. Gruber</name><name sortKey="Kuchler, U" sort="Kuchler, U" uniqKey="Kuchler U" first="U." last="Kuchler">U. Kuchler</name><name sortKey="Luvizuto, E R" sort="Luvizuto, E R" uniqKey="Luvizuto E" first="E. R." last="Luvizuto">E. R. Luvizuto</name><name sortKey="Luvizuto, E R" sort="Luvizuto, E R" uniqKey="Luvizuto E" first="E. R." last="Luvizuto">E. R. Luvizuto</name><name sortKey="Tangl, S" sort="Tangl, S" uniqKey="Tangl S" first="S." last="Tangl">S. Tangl</name><name sortKey="Tangl, S" sort="Tangl, S" uniqKey="Tangl S" first="S." last="Tangl">S. Tangl</name><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G." last="Watzek">G. Watzek</name><name sortKey="Watzek, G" sort="Watzek, G" uniqKey="Watzek G" first="G." last="Watzek">G. 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