Longitudinal effects of clinical therapy and the edentulous state on the transformation of lymphocytes from patients with severe periodontitis.
Identifieur interne : 00DD20 ( Main/Exploration ); précédent : 00DD19; suivant : 00DD21Longitudinal effects of clinical therapy and the edentulous state on the transformation of lymphocytes from patients with severe periodontitis.
Auteurs : J J Baker ; W E Wright ; S P Chan ; J J OppenheimSource :
- Clinical and Experimental Immunology [ 0009-9104 ] ; 1978.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Antigènes bactériens, Bouche édentée, Parodontite, Plaque dentaire.
- pharmacologie : Streptolysines.
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Humains, Parodontite, Études longitudinales.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antigens, Bacterial.
- immunology : Dental Plaque, Mouth, Edentulous, Periodontitis.
- chemical , pharmacology : Streptolysins.
- therapy : Periodontitis.
- Adult, Humans, Longitudinal Studies, Lymphocyte Activation, Middle Aged.
Abstract
Twenty dentulous subjects undergoing clinical therapy for severe periodontitis were used to determine the longitudinal effects of bacterial plaque reduction in vitro lymphocyte transformation. The therapy consisted of either complete extractions or partial extractions and periodontal surgery combined with rigorous oral hygiene. Prior to therapy lymphocytes from these subjects responded significantly to Streptolysin O (SLO) but were not transformed significantly by solubilized dental plaque. However, after therapy lymphocytes from these same subjects responded significantly to both solubilized dental plaque and SLO. This indicates that the severe periodontitis patients were specifically unresponsive to solubilized dental plaque prior to therapy. The mechanism of the unresponsiveness is not clear, but probably does not involve serum factors because supplementation of the lymphocyte cultures with pooled homologous plasma from individuals with gingivitis or moderate periodontitis (instead of the patient's autologous plasma) did not significantly change the mean lymphocyte responses to solubilized dental plaque. In addition, lymphocytes from eleven long-term (5--18 yr) edentulous subjects, who were free of oral inflammation, were significantly transformed by solubilized dental plaque. The latter lymphocyte responses and those of the treated periodontitis patients could be due either to the presence of low levels of oral bacteria in the edentulous mouth or to the lymphocyte transformation assay being a measure of previous antigen sensitization rather than current disease status. In either case, lymphocyte transformation to solubilized dental plaque is not a useful diagnostic tool in periodontitis, but should continue to be a valuable research tool for investigating pathological mechanisms in periodontitis.
Url:
PubMed: 737903
PubMed Central: 1537494
Affiliations:
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last="Oppenheim">J J Oppenheim</name></author></analytic><series><title level="j">Clinical and Experimental Immunology</title><idno type="ISSN">0009-9104</idno><idno type="eISSN">1365-2249</idno><imprint><date when="1978">1978</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Bacterial (immunology)</term><term>Dental Plaque (immunology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Lymphocyte Activation</term><term>Middle Aged</term><term>Mouth, Edentulous (immunology)</term><term>Periodontitis (immunology)</term><term>Periodontitis (therapy)</term><term>Streptolysins (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes bactériens (immunologie)</term><term>Bouche édentée (immunologie)</term><term>Humains</term><term>Parodontite ()</term><term>Parodontite (immunologie)</term><term>Plaque dentaire (immunologie)</term><term>Streptolysines (pharmacologie)</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes bactériens</term><term>Bouche édentée</term><term>Parodontite</term><term>Plaque dentaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dental Plaque</term><term>Mouth, Edentulous</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Streptolysines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Streptolysins</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Periodontitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Longitudinal Studies</term><term>Lymphocyte Activation</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Humains</term><term>Parodontite</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Twenty dentulous subjects undergoing clinical therapy for severe periodontitis were used to determine the longitudinal effects of bacterial plaque reduction in vitro lymphocyte transformation. The therapy consisted of either complete extractions or partial extractions and periodontal surgery combined with rigorous oral hygiene. Prior to therapy lymphocytes from these subjects responded significantly to Streptolysin O (SLO) but were not transformed significantly by solubilized dental plaque. However, after therapy lymphocytes from these same subjects responded significantly to both solubilized dental plaque and SLO. This indicates that the severe periodontitis patients were specifically unresponsive to solubilized dental plaque prior to therapy. The mechanism of the unresponsiveness is not clear, but probably does not involve serum factors because supplementation of the lymphocyte cultures with pooled homologous plasma from individuals with gingivitis or moderate periodontitis (instead of the patient's autologous plasma) did not significantly change the mean lymphocyte responses to solubilized dental plaque. In addition, lymphocytes from eleven long-term (5--18 yr) edentulous subjects, who were free of oral inflammation, were significantly transformed by solubilized dental plaque. The latter lymphocyte responses and those of the treated periodontitis patients could be due either to the presence of low levels of oral bacteria in the edentulous mouth or to the lymphocyte transformation assay being a measure of previous antigen sensitization rather than current disease status. In either case, lymphocyte transformation to solubilized dental plaque is not a useful diagnostic tool in periodontitis, but should continue to be a valuable research tool for investigating pathological mechanisms in periodontitis.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baker, J J" sort="Baker, J J" uniqKey="Baker J" first="J J" last="Baker">J J Baker</name><name sortKey="Chan, S P" sort="Chan, S P" uniqKey="Chan S" first="S P" last="Chan">S P Chan</name><name sortKey="Oppenheim, J J" sort="Oppenheim, J J" uniqKey="Oppenheim J" first="J J" last="Oppenheim">J J Oppenheim</name><name sortKey="Wright, W E" sort="Wright, W E" uniqKey="Wright W" first="W E" last="Wright">W E Wright</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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