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Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Identifieur interne : 00AC51 ( Main/Exploration ); précédent : 00AC50; suivant : 00AC52

Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Auteurs : A. Fournet [France] ; A. A. Barrios ; V. Munoz ; R. Hocquemiller [France] ; F. Roblot [France] ; A. Cave [France]

Source :

Planta medica [ 0032-0943 ] ; 1994.

RBID : Pascal:94-0221064

Descripteurs français

Pascal (Inist)
- Origine végétale, Plante médicinale, Pharmacognosie, Médecine traditionnelle, Antiparasitaire, Leishmaniose, Peau, Isolement, Analyse structurale, Activité biologique, Tige, Ecorce, Animal, Souris, In vitro, Bolivie, Ulmaceae, Leishmania, Trypanosoma cruzi, In vivo, Phytothérapie, Traitement, Tétralone, Ampelocera edentula.
Wicri :
- geographic : Bolivie.
- topic : Plante médicinale.

English descriptors

KwdEn :
- Animal, Bark, Biological activity, Bolivia, Folk medicine, In vitro, In vivo, Isolation, Leishmania, Leishmaniasis, Medicinal plant, Mouse, Parasiticid, Pharmacognosy, Phytotherapy, Plant origin, Skin, Stem, Structural analysis, Treatment, Trypanosoma cruzi, Ulmaceae.

Abstract

The stem bark of Ampelocera edentula Huhlm. (Ulmaceae) is used by the Chimanes Indians from Bolivia for the treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. A chloroform extract of the stem barks was found to be active against extracellular forms of Leishmania ssp. and Trypanosoma cruzi at 50 μg/ml. Bioassay-guided fractionation of this extract allowed us to isolate one active compound. Its structure was elucidated by spectral and chemical studies as 4-hydroxy1-tetralone. BALB/c mice infected with L. amazonensis (PH8) or L. venezuelensis were treated one day after the parasitic infection with 4-hydroxy-1-tetralone (25 mg / kg/day) or with reference drug, Glucantime® (56 mg Sb^v/kg/day) for 14 days

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 00AC51

Le document en format XML

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<front><div type="abstract" xml:lang="en">The stem bark of Ampelocera edentula Huhlm. (Ulmaceae) is used by the Chimanes Indians from Bolivia for the treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. A chloroform extract of the stem barks was found to be active against extracellular forms of Leishmania ssp. and Trypanosoma cruzi at 50 μg/ml. Bioassay-guided fractionation of this extract allowed us to isolate one active compound. Its structure was elucidated by spectral and chemical studies as 4-hydroxy1-tetralone. BALB/c mice infected with L. amazonensis (PH8) or L. venezuelensis were treated one day after the parasitic infection with 4-hydroxy-1-tetralone (25 mg / kg/day) or with reference drug, Glucantime® (56 mg Sb<sup>v</sup>
/kg/day) for 14 days</div>
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Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Antileishmanial activity of a tetralone isolated from Ampelocera edentula, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri