Genetic segregation analyses of serum IgG2 levels.
Identifieur interne : 00A065 ( Main/Exploration ); précédent : 00A064; suivant : 00A066Genetic segregation analyses of serum IgG2 levels.
Auteurs : M. L. Marazita ; H. Lu ; M. E. Cooper ; S. M. Quinn ; J. Zhang ; J. A. Burmeister ; J. V. Califano ; J. P. Pandey ; H. A. Schenkein ; J. G. TewSource :
- American Journal of Human Genetics [ 0002-9297 ] ; 1996.
Abstract
Summary : The aim of this study was to determine whether there was evidence for a genetic component in the immune response as measured by IgG2 levels. The study was motivated by our studies of early-onset periodontitis (EOP), a group of disorders characterized by rapid destruction of the supporting tissues of the teeth in otherwise healthy individuals. EOP has two subforms, localized juvenile periodontitis (LJP) and a generalized form (G-EOP). IgG2 levels are elevated in LJP but not G-EOP individuals; and African-American IgG2 levels are higher than Caucasian levels regardless of EOP status. IgG2 levels were determined in 123 EOP families and in 508 unrelated non-EOP control individuals. Segregation analysis under the regressive model approach of Bonney was used to analyze IgG2 levels for evidence of major locus segregation. After adjusting for LJP status, race, sex, and age, the best fitting model was an autosomal codominant major locus model (accounting for approximately 62% of the variance in IgG2), plus residual parent/offspring and spousal correlations. Smoking and GM23 are also known to affect IgG2 levels. If additional adjustments are made for smoking and GM23, the best-fitting model is still a codominant major locus but with no significant residual correlations.
Url:
PubMed: 8651265
PubMed Central: 1914630
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001030
- to stream Pmc, to step Curation: 001030
- to stream Pmc, to step Checkpoint: 002844
- to stream Ncbi, to step Merge: 009717
- to stream Ncbi, to step Curation: 009717
- to stream Ncbi, to step Checkpoint: 009717
- to stream Main, to step Merge: 00A613
- to stream Main, to step Curation: 00A065
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic segregation analyses of serum IgG2 levels.</title><author><name sortKey="Marazita, M L" sort="Marazita, M L" uniqKey="Marazita M" first="M. L." last="Marazita">M. L. Marazita</name></author><author><name sortKey="Lu, H" sort="Lu, H" uniqKey="Lu H" first="H." last="Lu">H. Lu</name></author><author><name sortKey="Cooper, M E" sort="Cooper, M E" uniqKey="Cooper M" first="M. E." last="Cooper">M. E. Cooper</name></author><author><name sortKey="Quinn, S M" sort="Quinn, S M" uniqKey="Quinn S" first="S. M." last="Quinn">S. M. Quinn</name></author><author><name sortKey="Zhang, J" sort="Zhang, J" uniqKey="Zhang J" first="J." last="Zhang">J. Zhang</name></author><author><name sortKey="Burmeister, J A" sort="Burmeister, J A" uniqKey="Burmeister J" first="J. A." last="Burmeister">J. A. Burmeister</name></author><author><name sortKey="Califano, J V" sort="Califano, J V" uniqKey="Califano J" first="J. V." last="Califano">J. V. Califano</name></author><author><name sortKey="Pandey, J P" sort="Pandey, J P" uniqKey="Pandey J" first="J. P." last="Pandey">J. P. Pandey</name></author><author><name sortKey="Schenkein, H A" sort="Schenkein, H A" uniqKey="Schenkein H" first="H. A." last="Schenkein">H. A. Schenkein</name></author><author><name sortKey="Tew, J G" sort="Tew, J G" uniqKey="Tew J" first="J. G." last="Tew">J. G. Tew</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">8651265</idno><idno type="pmc">1914630</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914630</idno><idno type="RBID">PMC:1914630</idno><date when="1996">1996</date><idno type="wicri:Area/Pmc/Corpus">001030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001030</idno><idno type="wicri:Area/Pmc/Curation">001030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001030</idno><idno type="wicri:Area/Pmc/Checkpoint">002844</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002844</idno><idno type="wicri:Area/Ncbi/Merge">009717</idno><idno type="wicri:Area/Ncbi/Curation">009717</idno><idno type="wicri:Area/Ncbi/Checkpoint">009717</idno><idno type="wicri:doubleKey">0002-9297:1996:Marazita M:genetic:segregation:analyses</idno><idno type="wicri:Area/Main/Merge">00A613</idno><idno type="wicri:Area/Main/Curation">00A065</idno><idno type="wicri:Area/Main/Exploration">00A065</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic segregation analyses of serum IgG2 levels.</title><author><name sortKey="Marazita, M L" sort="Marazita, M L" uniqKey="Marazita M" first="M. L." last="Marazita">M. L. Marazita</name></author><author><name sortKey="Lu, H" sort="Lu, H" uniqKey="Lu H" first="H." last="Lu">H. Lu</name></author><author><name sortKey="Cooper, M E" sort="Cooper, M E" uniqKey="Cooper M" first="M. E." last="Cooper">M. E. Cooper</name></author><author><name sortKey="Quinn, S M" sort="Quinn, S M" uniqKey="Quinn S" first="S. M." last="Quinn">S. M. Quinn</name></author><author><name sortKey="Zhang, J" sort="Zhang, J" uniqKey="Zhang J" first="J." last="Zhang">J. Zhang</name></author><author><name sortKey="Burmeister, J A" sort="Burmeister, J A" uniqKey="Burmeister J" first="J. A." last="Burmeister">J. A. Burmeister</name></author><author><name sortKey="Califano, J V" sort="Califano, J V" uniqKey="Califano J" first="J. V." last="Califano">J. V. Califano</name></author><author><name sortKey="Pandey, J P" sort="Pandey, J P" uniqKey="Pandey J" first="J. P." last="Pandey">J. P. Pandey</name></author><author><name sortKey="Schenkein, H A" sort="Schenkein, H A" uniqKey="Schenkein H" first="H. A." last="Schenkein">H. A. Schenkein</name></author><author><name sortKey="Tew, J G" sort="Tew, J G" uniqKey="Tew J" first="J. G." last="Tew">J. G. Tew</name></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Summary : The aim of this study was to determine whether there was evidence for a genetic component in the immune response as measured by IgG2 levels. The study was motivated by our studies of early-onset periodontitis (EOP), a group of disorders characterized by rapid destruction of the supporting tissues of the teeth in otherwise healthy individuals. EOP has two subforms, localized juvenile periodontitis (LJP) and a generalized form (G-EOP). IgG2 levels are elevated in LJP but not G-EOP individuals; and African-American IgG2 levels are higher than Caucasian levels regardless of EOP status. IgG2 levels were determined in 123 EOP families and in 508 unrelated non-EOP control individuals. Segregation analysis under the regressive model approach of Bonney was used to analyze IgG2 levels for evidence of major locus segregation. After adjusting for LJP status, race, sex, and age, the best fitting model was an autosomal codominant major locus model (accounting for approximately 62% of the variance in IgG2), plus residual parent/offspring and spousal correlations. Smoking and GM23 are also known to affect IgG2 levels. If additional adjustments are made for smoking and GM23, the best-fitting model is still a codominant major locus but with no significant residual correlations.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Burmeister, J A" sort="Burmeister, J A" uniqKey="Burmeister J" first="J. A." last="Burmeister">J. A. Burmeister</name><name sortKey="Califano, J V" sort="Califano, J V" uniqKey="Califano J" first="J. V." last="Califano">J. V. Califano</name><name sortKey="Cooper, M E" sort="Cooper, M E" uniqKey="Cooper M" first="M. E." last="Cooper">M. E. Cooper</name><name sortKey="Lu, H" sort="Lu, H" uniqKey="Lu H" first="H." last="Lu">H. Lu</name><name sortKey="Marazita, M L" sort="Marazita, M L" uniqKey="Marazita M" first="M. L." last="Marazita">M. L. Marazita</name><name sortKey="Pandey, J P" sort="Pandey, J P" uniqKey="Pandey J" first="J. P." last="Pandey">J. P. Pandey</name><name sortKey="Quinn, S M" sort="Quinn, S M" uniqKey="Quinn S" first="S. M." last="Quinn">S. M. Quinn</name><name sortKey="Schenkein, H A" sort="Schenkein, H A" uniqKey="Schenkein H" first="H. A." last="Schenkein">H. A. Schenkein</name><name sortKey="Tew, J G" sort="Tew, J G" uniqKey="Tew J" first="J. G." last="Tew">J. G. Tew</name><name sortKey="Zhang, J" sort="Zhang, J" uniqKey="Zhang J" first="J." last="Zhang">J. Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00A065 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00A065 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:1914630
|texte= Genetic segregation analyses of serum IgG2 levels.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8651265" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |