Streptococcus mutans major adhesion surface protein, P1 (I/II), does not contribute to attachment to valvular vegetations or to the development of endocarditis in a rat model
Identifieur interne : 009D58 ( Main/Exploration ); précédent : 009D57; suivant : 009D59Streptococcus mutans major adhesion surface protein, P1 (I/II), does not contribute to attachment to valvular vegetations or to the development of endocarditis in a rat model
Auteurs : M. Ryd [Suède] ; T. Schennings [Suède] ; M. Flock [Suède] ; A. Heimdahl [Suède] ; J.-I. Flock [Suède]Source :
- Archives of Oral Biology [ 0003-9969 ] ; 1997.
English descriptors
- KwdEn :
- Adhesion, Aortic, Blood samples, Endocarditis, Femoral vein, Fibronectin binding, Immunol, Infective, Infective endocarditis, Lehner, Microbiol, Mutans, Oral surgery, P1 antigen in endocarditis, Salivary pellicle, Strep, Strep. mutans, Streptococcus, Streptococcus mutans, Valvular vegetations, Vegetation, c.f.u..
- Teeft :
Abstract
Abstract: Streptococcus mutans P1 antigen functions as an adhesion factor for binding to salivary pellicle on tooth surfaces. It induces increased antibody titres in patients with Strep. mutans endocarditis. A mutant of Strep. mutans deficient in the function of the gene (spa P) encoding the surface antigen P1, and its isogenic parental strain, were used in a rat endocarditis experiment. Absence of P1 did not decrease adhesion to vegetations determined 1 h after intravenous infection. The number of bacteria recovered from valvular vegetations after 48 h from animals with manifest endocarditis did not differ between the strains. Consequently, the PI antigen appears to be unimportant both for adhesion and virulence in endocarditis caused by Strep. mutans.
Url:
DOI: 10.1016/S0003-9969(96)00035-0
Affiliations:
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Flock</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Surgery, Karolinska Institute, Huddinge University Hospital, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Heimdahl, A" sort="Heimdahl, A" uniqKey="Heimdahl A" first="A." last="Heimdahl">A. Heimdahl</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Surgery, Karolinska Institute, Huddinge University Hospital, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Flock, J I" sort="Flock, J I" uniqKey="Flock J" first="J.-I." last="Flock">J.-I. Flock</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Microbiology, Huddinge University Hospital, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oral Surgery, Karolinska Institute, Huddinge University Hospital, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Oral Biology</title><title level="j" type="abbrev">AOB</title><idno type="ISSN">0003-9969</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">41</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="999">999</biblScope><biblScope unit="page" to="1002">1002</biblScope></imprint><idno type="ISSN">0003-9969</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-9969</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adhesion</term><term>Aortic</term><term>Blood samples</term><term>Endocarditis</term><term>Femoral vein</term><term>Fibronectin binding</term><term>Immunol</term><term>Infective</term><term>Infective endocarditis</term><term>Lehner</term><term>Microbiol</term><term>Mutans</term><term>Oral surgery</term><term>P1 antigen in endocarditis</term><term>Salivary pellicle</term><term>Strep</term><term>Strep. mutans</term><term>Streptococcus</term><term>Streptococcus mutans</term><term>Valvular vegetations</term><term>Vegetation</term><term>c.f.u.</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adhesion</term><term>Aortic</term><term>Blood samples</term><term>Endocarditis</term><term>Femoral vein</term><term>Fibronectin binding</term><term>Immunol</term><term>Infective</term><term>Infective endocarditis</term><term>Lehner</term><term>Microbiol</term><term>Mutans</term><term>Oral surgery</term><term>Salivary pellicle</term><term>Strep</term><term>Streptococcus</term><term>Streptococcus mutans</term><term>Valvular vegetations</term><term>Vegetation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Streptococcus mutans P1 antigen functions as an adhesion factor for binding to salivary pellicle on tooth surfaces. It induces increased antibody titres in patients with Strep. mutans endocarditis. A mutant of Strep. mutans deficient in the function of the gene (spa P) encoding the surface antigen P1, and its isogenic parental strain, were used in a rat endocarditis experiment. Absence of P1 did not decrease adhesion to vegetations determined 1 h after intravenous infection. The number of bacteria recovered from valvular vegetations after 48 h from animals with manifest endocarditis did not differ between the strains. Consequently, the PI antigen appears to be unimportant both for adhesion and virulence in endocarditis caused by Strep. mutans.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Ryd, M" sort="Ryd, M" uniqKey="Ryd M" first="M." last="Ryd">M. Ryd</name></noRegion><name sortKey="Flock, J I" sort="Flock, J I" uniqKey="Flock J" first="J.-I." last="Flock">J.-I. Flock</name><name sortKey="Flock, J I" sort="Flock, J I" uniqKey="Flock J" first="J.-I." last="Flock">J.-I. Flock</name><name sortKey="Flock, M" sort="Flock, M" uniqKey="Flock M" first="M." last="Flock">M. Flock</name><name sortKey="Heimdahl, A" sort="Heimdahl, A" uniqKey="Heimdahl A" first="A." last="Heimdahl">A. Heimdahl</name><name sortKey="Ryd, M" sort="Ryd, M" uniqKey="Ryd M" first="M." last="Ryd">M. Ryd</name><name sortKey="Schennings, T" sort="Schennings, T" uniqKey="Schennings T" first="T." last="Schennings">T. Schennings</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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