Benign alveolar ridge keratosis (oral lichen simplex chronicus) : A distinct clinicopathologic entity
Identifieur interne : 006556 ( Main/Exploration ); précédent : 006555; suivant : 006557Benign alveolar ridge keratosis (oral lichen simplex chronicus) : A distinct clinicopathologic entity
Auteurs : Easwar Natarajan [États-Unis] ; Sook-Bin Woo [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 2008.
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- Pascal (Inist)
English descriptors
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Abstract
Benign alveolar ridge keratosis is a common benign white papule or plaque that occurs on the keratinized gingiva of the maxillary or mandibular alveolar ridge that is probably traumatic/frictional in origin, with characteristic histologic features, similar to those of lichen simplex chronicus of the skin. This is a retrospective study of 108 consecutive specimens displaying characteristic histopathologic features of benign alveolar ridge keratosis accessioned during a 36-month period. There was a male:female ratio of 3.7:1. It occurred on the attached gingiva, with the retromolar area and the edentulous alveolar ridge involved in 51% and 49% of cases, respectively; 19% were bilateral and all bilateral cases were on the retromolar pad. Detailed clinical information was available on 27 cases by a mail-in questionnaire. Histologically, the lesions were characterized by moderate to marked hyperorthokeratosis and wedge-shaped hypergranulosis. The epithelium exhibited slight surface papillomatosis and acanthosis in the form of long, tapered rete ridges that frequently anastomosed at the base. There was generally insignificant inflammation. These features are similar if not identical to lichen simplex chronicus of the skin, a benign condition caused by chronic irritation. Ten randomly selected cases were immunostained for p16INK4A(p16), a tumor suppressor protein expressed in dysplastic epithelium. All lesions were negative for p16. Benign alveolar ridge keratosis is a specific clinicopathologic entity that should be removed from the category of leukoplakia as is currently the practice for clinical white lesions with a specific, consistently recognizable histologic appearance.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Benign alveolar ridge keratosis (oral lichen simplex chronicus) : A distinct clinicopathologic entity</title><author><name sortKey="Natarajan, Easwar" sort="Natarajan, Easwar" uniqKey="Natarajan E" first="Easwar" last="Natarajan">Easwar Natarajan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Woo, Sook Bin" sort="Woo, Sook Bin" uniqKey="Woo S" first="Sook-Bin" last="Woo">Sook-Bin Woo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine</s1><s2>Boston</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pathology Services Inc</s1><s2>Cambridge</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pathology Services Inc</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0126551</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0126551 INIST</idno><idno type="RBID">Pascal:08-0126551</idno><idno type="wicri:Area/PascalFrancis/Corpus">000384</idno><idno type="wicri:Area/PascalFrancis/Curation">000318</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000373</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000373</idno><idno type="wicri:doubleKey">0190-9622:2008:Natarajan E:benign:alveolar:ridge</idno><idno type="wicri:Area/Main/Merge">006645</idno><idno type="wicri:Area/Main/Curation">006556</idno><idno type="wicri:Area/Main/Exploration">006556</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Benign alveolar ridge keratosis (oral lichen simplex chronicus) : A distinct clinicopathologic entity</title><author><name sortKey="Natarajan, Easwar" sort="Natarajan, Easwar" uniqKey="Natarajan E" first="Easwar" last="Natarajan">Easwar Natarajan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Woo, Sook Bin" sort="Woo, Sook Bin" uniqKey="Woo S" first="Sook-Bin" last="Woo">Sook-Bin Woo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine</s1><s2>Boston</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pathology Services Inc</s1><s2>Cambridge</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pathology Services Inc</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of the American Academy of Dermatology</title><title level="j" type="abbreviated">J. Am. Acad. Dermatol.</title><idno type="ISSN">0190-9622</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the American Academy of Dermatology</title><title level="j" type="abbreviated">J. Am. Acad. Dermatol.</title><idno type="ISSN">0190-9622</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Dermatology</term><term>Histopathology</term><term>Keratosis</term><term>Neurodermatitis</term><term>Oral administration</term><term>Symptomatology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Névrodermite</term><term>Anatomopathologie</term><term>Histopathologie</term><term>Kératose</term><term>Voie orale</term><term>Symptomatologie</term><term>Dermatologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Benign alveolar ridge keratosis is a common benign white papule or plaque that occurs on the keratinized gingiva of the maxillary or mandibular alveolar ridge that is probably traumatic/frictional in origin, with characteristic histologic features, similar to those of lichen simplex chronicus of the skin. This is a retrospective study of 108 consecutive specimens displaying characteristic histopathologic features of benign alveolar ridge keratosis accessioned during a 36-month period. There was a male:female ratio of 3.7:1. It occurred on the attached gingiva, with the retromolar area and the edentulous alveolar ridge involved in 51% and 49% of cases, respectively; 19% were bilateral and all bilateral cases were on the retromolar pad. Detailed clinical information was available on 27 cases by a mail-in questionnaire. Histologically, the lesions were characterized by moderate to marked hyperorthokeratosis and wedge-shaped hypergranulosis. The epithelium exhibited slight surface papillomatosis and acanthosis in the form of long, tapered rete ridges that frequently anastomosed at the base. There was generally insignificant inflammation. These features are similar if not identical to lichen simplex chronicus of the skin, a benign condition caused by chronic irritation. Ten randomly selected cases were immunostained for p16INK4A(p16), a tumor suppressor protein expressed in dysplastic epithelium. All lesions were negative for p16. Benign alveolar ridge keratosis is a specific clinicopathologic entity that should be removed from the category of leukoplakia as is currently the practice for clinical white lesions with a specific, consistently recognizable histologic appearance.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Boston</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Natarajan, Easwar" sort="Natarajan, Easwar" uniqKey="Natarajan E" first="Easwar" last="Natarajan">Easwar Natarajan</name></noRegion><name sortKey="Woo, Sook Bin" sort="Woo, Sook Bin" uniqKey="Woo S" first="Sook-Bin" last="Woo">Sook-Bin Woo</name><name sortKey="Woo, Sook Bin" sort="Woo, Sook Bin" uniqKey="Woo S" first="Sook-Bin" last="Woo">Sook-Bin Woo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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